Childhood invasive pneumococcal disease: a hospital-based study from Malaysia
Aim: New conjugate vaccine for Streptococcus pneumoniae has been introduced in Malaysia recently. Information on infection due to S. pneumoniae in Malaysian children is scarce. We conducted a retrospective chart review of childhood invasive pneumococcal disease (IPD) presented to a single centre in...
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Wiley
2007
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| author | Lim, L.H. Lee, Way Seah Parasakthi, N. |
| author_facet | Lim, L.H. Lee, Way Seah Parasakthi, N. |
| author_sort | Lim, L.H. |
| collection | UM |
| description | Aim: New conjugate vaccine for Streptococcus pneumoniae has been introduced in Malaysia recently. Information on infection due to S. pneumoniae in Malaysian children is scarce. We conducted a retrospective chart review of childhood invasive pneumococcal disease (IPD) presented to a single centre in Malaysia. Methods: A retrospective review of 5 years and 4 months of all cases of IPD in children younger than 14 years of age (May 1999-August 2004) seen at the University of Malaya Medical Centre (UMMC), Kuala Lumpur, was conducted. Cases were identified from the record of Department of Medical Microbiology, UMMC. Results: IPD was identified in 50 children (median age 1.1 years, range 2 weeks-14 years) during the study period. Seventy-six per cent of the cases were younger than 2 years of age. Pattern of infections noted include definite pneumonia (n = 8), probable pneumonia (n = 33), meningitis (n = 4), bacteraemia without focus (n = 4) and septic arthritis (n = 1 each). Pre-morbid diseases were present in 28 of all cases. Complications (n = 12, 24) due to IPD were seizures (n = 5), pleural effusion/empyema (n = 4), cerebral palsy (n = 2) and deafness (n = 1). No deaths were attributed to IPD. Sixty-two per cent of the pneumococcal isolates were penicillin non-susceptible and were detected throughout the study period. Conclusions: IPD is associated with high morbidity, particularly among young children. Majority of the isolates were penicillin-non-susceptible strains. Additional information on the serotype of S. pneumoniae isolated is necessary to assess the potential impact of immunisation on preventing pneumococcal infection in Malaysia. |
| first_indexed | 2024-03-06T05:27:16Z |
| format | Article |
| id | um.eprints-10896 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:27:16Z |
| publishDate | 2007 |
| publisher | Wiley |
| record_format | dspace |
| spelling | um.eprints-108962019-02-25T07:58:16Z http://eprints.um.edu.my/10896/ Childhood invasive pneumococcal disease: a hospital-based study from Malaysia Lim, L.H. Lee, Way Seah Parasakthi, N. R Medicine RJ Pediatrics Aim: New conjugate vaccine for Streptococcus pneumoniae has been introduced in Malaysia recently. Information on infection due to S. pneumoniae in Malaysian children is scarce. We conducted a retrospective chart review of childhood invasive pneumococcal disease (IPD) presented to a single centre in Malaysia. Methods: A retrospective review of 5 years and 4 months of all cases of IPD in children younger than 14 years of age (May 1999-August 2004) seen at the University of Malaya Medical Centre (UMMC), Kuala Lumpur, was conducted. Cases were identified from the record of Department of Medical Microbiology, UMMC. Results: IPD was identified in 50 children (median age 1.1 years, range 2 weeks-14 years) during the study period. Seventy-six per cent of the cases were younger than 2 years of age. Pattern of infections noted include definite pneumonia (n = 8), probable pneumonia (n = 33), meningitis (n = 4), bacteraemia without focus (n = 4) and septic arthritis (n = 1 each). Pre-morbid diseases were present in 28 of all cases. Complications (n = 12, 24) due to IPD were seizures (n = 5), pleural effusion/empyema (n = 4), cerebral palsy (n = 2) and deafness (n = 1). No deaths were attributed to IPD. Sixty-two per cent of the pneumococcal isolates were penicillin non-susceptible and were detected throughout the study period. Conclusions: IPD is associated with high morbidity, particularly among young children. Majority of the isolates were penicillin-non-susceptible strains. Additional information on the serotype of S. pneumoniae isolated is necessary to assess the potential impact of immunisation on preventing pneumococcal infection in Malaysia. Wiley 2007 Article PeerReviewed Lim, L.H. and Lee, Way Seah and Parasakthi, N. (2007) Childhood invasive pneumococcal disease: a hospital-based study from Malaysia. Journal of Paediatrics and Child Health, 43 (5). pp. 366-369. ISSN 1034-4810, DOI https://doi.org/10.1111/j.1440-1754.2007.01081.x <https://doi.org/10.1111/j.1440-1754.2007.01081.x>. http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1754.2007.01081.x/full 10.1111/j.1440-1754.2007.01081.x |
| spellingShingle | R Medicine RJ Pediatrics Lim, L.H. Lee, Way Seah Parasakthi, N. Childhood invasive pneumococcal disease: a hospital-based study from Malaysia |
| title | Childhood invasive pneumococcal disease: a hospital-based study from Malaysia |
| title_full | Childhood invasive pneumococcal disease: a hospital-based study from Malaysia |
| title_fullStr | Childhood invasive pneumococcal disease: a hospital-based study from Malaysia |
| title_full_unstemmed | Childhood invasive pneumococcal disease: a hospital-based study from Malaysia |
| title_short | Childhood invasive pneumococcal disease: a hospital-based study from Malaysia |
| title_sort | childhood invasive pneumococcal disease a hospital based study from malaysia |
| topic | R Medicine RJ Pediatrics |
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