Periodic lateralized epileptiform discharges (PLEDs) in cerebral lupus correlated with white-matter lesions in brain MRI and reduced cerebral blood flow in SPECT
This is a case report on an uncommon correlation between periodic lateralized epileptiform discharges (PLEDs) and white-matter lesions in cerebral lupus, and with a reduced cerebral blood flow (CBF) in single-photon emission computed tomography (SPECT). A 47-year-old woman with a long-term history o...
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| Format: | Article |
| Language: | English |
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Arnold Publishers (journals now owned by Sage)
2013
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| Online Access: | http://eprints.um.edu.my/11230/1/Aye-2013-Periodic_lateralized.pdf |
| _version_ | 1796946203729985536 |
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| author | Aye, S.M.M. Lim, K.S. Ramli, N.M. Tan, C.T. |
| author_facet | Aye, S.M.M. Lim, K.S. Ramli, N.M. Tan, C.T. |
| author_sort | Aye, S.M.M. |
| collection | UM |
| description | This is a case report on an uncommon correlation between periodic lateralized epileptiform discharges (PLEDs) and white-matter lesions in cerebral lupus, and with a reduced cerebral blood flow (CBF) in single-photon emission computed tomography (SPECT). A 47-year-old woman with a long-term history of systemic lupus erythematosus (SLE) presented with a seizure followed by frontal lobe dysfunction clinically. An electroencephalogram (EEG) showed bilateral independent PLEDs in the frontal region. A magnetic resonance image of the brain showed white-matter changes in the frontal periventricular region. Cerebral angiogram did not reveal any evidence of vasculitis. A cerebral SPECT with tracer injected during the EEG showing PLEDs showed a reduction in CBF in the frontal regions. Clinical recovery was observed with intravenous immunoglobulin. This case shows that PLEDs can be seen with white-matter changes in SLE. Lupus (2013) 22, 510-514. |
| first_indexed | 2024-03-06T05:28:08Z |
| format | Article |
| id | um.eprints-11230 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:28:08Z |
| publishDate | 2013 |
| publisher | Arnold Publishers (journals now owned by Sage) |
| record_format | dspace |
| spelling | um.eprints-112302014-12-08T07:01:19Z http://eprints.um.edu.my/11230/ Periodic lateralized epileptiform discharges (PLEDs) in cerebral lupus correlated with white-matter lesions in brain MRI and reduced cerebral blood flow in SPECT Aye, S.M.M. Lim, K.S. Ramli, N.M. Tan, C.T. R Medicine This is a case report on an uncommon correlation between periodic lateralized epileptiform discharges (PLEDs) and white-matter lesions in cerebral lupus, and with a reduced cerebral blood flow (CBF) in single-photon emission computed tomography (SPECT). A 47-year-old woman with a long-term history of systemic lupus erythematosus (SLE) presented with a seizure followed by frontal lobe dysfunction clinically. An electroencephalogram (EEG) showed bilateral independent PLEDs in the frontal region. A magnetic resonance image of the brain showed white-matter changes in the frontal periventricular region. Cerebral angiogram did not reveal any evidence of vasculitis. A cerebral SPECT with tracer injected during the EEG showing PLEDs showed a reduction in CBF in the frontal regions. Clinical recovery was observed with intravenous immunoglobulin. This case shows that PLEDs can be seen with white-matter changes in SLE. Lupus (2013) 22, 510-514. Arnold Publishers (journals now owned by Sage) 2013 Article PeerReviewed application/pdf en http://eprints.um.edu.my/11230/1/Aye-2013-Periodic_lateralized.pdf Aye, S.M.M. and Lim, K.S. and Ramli, N.M. and Tan, C.T. (2013) Periodic lateralized epileptiform discharges (PLEDs) in cerebral lupus correlated with white-matter lesions in brain MRI and reduced cerebral blood flow in SPECT. Lupus, 22 (5). pp. 510-514. ISSN 0961-2033, DOI https://doi.org/10.1177/0961203312474705 <https://doi.org/10.1177/0961203312474705>. http://lup.sagepub.com/content/22/5/510.full.pdf+html http://dx.doi.org/10.1177/0961203312474705 |
| spellingShingle | R Medicine Aye, S.M.M. Lim, K.S. Ramli, N.M. Tan, C.T. Periodic lateralized epileptiform discharges (PLEDs) in cerebral lupus correlated with white-matter lesions in brain MRI and reduced cerebral blood flow in SPECT |
| title | Periodic lateralized epileptiform discharges (PLEDs) in cerebral lupus correlated with white-matter lesions in brain MRI and reduced cerebral blood flow in SPECT |
| title_full | Periodic lateralized epileptiform discharges (PLEDs) in cerebral lupus correlated with white-matter lesions in brain MRI and reduced cerebral blood flow in SPECT |
| title_fullStr | Periodic lateralized epileptiform discharges (PLEDs) in cerebral lupus correlated with white-matter lesions in brain MRI and reduced cerebral blood flow in SPECT |
| title_full_unstemmed | Periodic lateralized epileptiform discharges (PLEDs) in cerebral lupus correlated with white-matter lesions in brain MRI and reduced cerebral blood flow in SPECT |
| title_short | Periodic lateralized epileptiform discharges (PLEDs) in cerebral lupus correlated with white-matter lesions in brain MRI and reduced cerebral blood flow in SPECT |
| title_sort | periodic lateralized epileptiform discharges pleds in cerebral lupus correlated with white matter lesions in brain mri and reduced cerebral blood flow in spect |
| topic | R Medicine |
| url | http://eprints.um.edu.my/11230/1/Aye-2013-Periodic_lateralized.pdf |
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