Anthraquinones with antiplasmodial activity from the roots of rennellia elliptica korth. (Rubiaceae)
Dichloromethane root extract of Rennellia elliptica Korth. showed strong inhibition of Plasmodium falciparum growth in vitro with an IC(50) value of 4.04 mu g/mL. A phytochemical study of the dichloromethane root extract has led to the isolation and characterization of a new anthraquinone, 1,2-dimet...
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MDPI AG
2010
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| author | Osman, C.P. Ismail, N.H. Ahmad, R. Ahmat, N. Awang, K. Jaafar, F.M. |
| author_facet | Osman, C.P. Ismail, N.H. Ahmad, R. Ahmat, N. Awang, K. Jaafar, F.M. |
| author_sort | Osman, C.P. |
| collection | UM |
| description | Dichloromethane root extract of Rennellia elliptica Korth. showed strong inhibition of Plasmodium falciparum growth in vitro with an IC(50) value of 4.04 mu g/mL. A phytochemical study of the dichloromethane root extract has led to the isolation and characterization of a new anthraquinone, 1,2-dimethoxy-6-methyl-9,10-anthraquinone (1), and ten known anthraquinones: 1-hydroxy-2-methoxy-6-methyl-9,10-anthraquinone (2), nordamnacanthal (3), 2-formyl-3-hydroxy-9,10-anthraquinone (4), damnacanthal (5), lucidin-omega-methyl ether (6), 3-hydroxy-2-methyl-9,10-anthraquinone (7), rubiadin (8), 3-hydroxy-2-methoxy-6-methyl-9,10-anthraquinone (9), rubiadin-1-methyl ether (10) and 3-hydroxy-2-hydroxymethyl-9,10-anthraquinone (11). Structural elucidation of all compounds was accomplished by modern spectroscopic methods, notably 1D and 2D NMR, IR, UV and HREIMS. The new anthraquinone 1, 2-formyl-3-hydroxy-9,10-anthraquinone (4) and 3-hydroxy-2-methyl-9,10-anthraquinone (7) possess strong antiplasmodial activity, with IC(50) values of 1.10, 0.63 and 0.34 mu M, respectively. |
| first_indexed | 2024-03-06T05:30:46Z |
| format | Article |
| id | um.eprints-12262 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:30:46Z |
| publishDate | 2010 |
| publisher | MDPI AG |
| record_format | dspace |
| spelling | um.eprints-122622015-01-20T02:56:56Z http://eprints.um.edu.my/12262/ Anthraquinones with antiplasmodial activity from the roots of rennellia elliptica korth. (Rubiaceae) Osman, C.P. Ismail, N.H. Ahmad, R. Ahmat, N. Awang, K. Jaafar, F.M. Q Science (General) Dichloromethane root extract of Rennellia elliptica Korth. showed strong inhibition of Plasmodium falciparum growth in vitro with an IC(50) value of 4.04 mu g/mL. A phytochemical study of the dichloromethane root extract has led to the isolation and characterization of a new anthraquinone, 1,2-dimethoxy-6-methyl-9,10-anthraquinone (1), and ten known anthraquinones: 1-hydroxy-2-methoxy-6-methyl-9,10-anthraquinone (2), nordamnacanthal (3), 2-formyl-3-hydroxy-9,10-anthraquinone (4), damnacanthal (5), lucidin-omega-methyl ether (6), 3-hydroxy-2-methyl-9,10-anthraquinone (7), rubiadin (8), 3-hydroxy-2-methoxy-6-methyl-9,10-anthraquinone (9), rubiadin-1-methyl ether (10) and 3-hydroxy-2-hydroxymethyl-9,10-anthraquinone (11). Structural elucidation of all compounds was accomplished by modern spectroscopic methods, notably 1D and 2D NMR, IR, UV and HREIMS. The new anthraquinone 1, 2-formyl-3-hydroxy-9,10-anthraquinone (4) and 3-hydroxy-2-methyl-9,10-anthraquinone (7) possess strong antiplasmodial activity, with IC(50) values of 1.10, 0.63 and 0.34 mu M, respectively. MDPI AG 2010 Article PeerReviewed Osman, C.P. and Ismail, N.H. and Ahmad, R. and Ahmat, N. and Awang, K. and Jaafar, F.M. (2010) Anthraquinones with antiplasmodial activity from the roots of rennellia elliptica korth. (Rubiaceae). Molecules, 15 (10). pp. 7218-7226. |
| spellingShingle | Q Science (General) Osman, C.P. Ismail, N.H. Ahmad, R. Ahmat, N. Awang, K. Jaafar, F.M. Anthraquinones with antiplasmodial activity from the roots of rennellia elliptica korth. (Rubiaceae) |
| title | Anthraquinones with antiplasmodial activity from the roots of rennellia elliptica korth. (Rubiaceae) |
| title_full | Anthraquinones with antiplasmodial activity from the roots of rennellia elliptica korth. (Rubiaceae) |
| title_fullStr | Anthraquinones with antiplasmodial activity from the roots of rennellia elliptica korth. (Rubiaceae) |
| title_full_unstemmed | Anthraquinones with antiplasmodial activity from the roots of rennellia elliptica korth. (Rubiaceae) |
| title_short | Anthraquinones with antiplasmodial activity from the roots of rennellia elliptica korth. (Rubiaceae) |
| title_sort | anthraquinones with antiplasmodial activity from the roots of rennellia elliptica korth rubiaceae |
| topic | Q Science (General) |
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