Ardeemins and cytochalasins from aspergillus terreus residing in Artemisia annua
Three new alkaloids, 15b-dehydro-5-N-acetylardeemin (3), 10-phenyl-[12]-cytochalasins Z16 (6) andZ17(7), were characterized from the liquid culture of the endophytic fungus Aspergillus terreus IFB-E030 along with six known derivatives, 5-N-acetylardeemin (1), 15b-beta-hydroxyl-5-N-acetylardeemin (2)...
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| Format: | Article |
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Georg Thieme Verlag Kg
2010
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| _version_ | 1796946384395436032 |
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| author | Zhang, Hua-Wei Zhang, J. Hu, S. Zhang, Zun-Jian Zhu, Cheng-Jian Ng, S.W. Tan, Ren-Xiang |
| author_facet | Zhang, Hua-Wei Zhang, J. Hu, S. Zhang, Zun-Jian Zhu, Cheng-Jian Ng, S.W. Tan, Ren-Xiang |
| author_sort | Zhang, Hua-Wei |
| collection | UM |
| description | Three new alkaloids, 15b-dehydro-5-N-acetylardeemin (3), 10-phenyl-[12]-cytochalasins Z16 (6) andZ17(7), were characterized from the liquid culture of the endophytic fungus Aspergillus terreus IFB-E030 along with six known derivatives, 5-N-acetylardeemin (1), 15b-beta-hydroxyl-5-N-acetylardeemin (2), cytochalasin E (4), rosellichalasin (5), cytochalasins Z11 (8), and Z13 (9). The structures of the new metabolites were established mainly by a combination of their 1D- and 2D-NMR spectra, single crystal X-ray diffraction, and the modified Mosher reaction. Biological assays indicated that cytochalasin Z17 (7) had moderate cytotoxicity against human nasopharyngeal epidermoid tumor KB cell line with an IC(50) value of 26.2 mu M. |
| first_indexed | 2024-03-06T05:30:52Z |
| format | Article |
| id | um.eprints-12319 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:30:52Z |
| publishDate | 2010 |
| publisher | Georg Thieme Verlag Kg |
| record_format | dspace |
| spelling | um.eprints-123192015-01-22T02:02:57Z http://eprints.um.edu.my/12319/ Ardeemins and cytochalasins from aspergillus terreus residing in Artemisia annua Zhang, Hua-Wei Zhang, J. Hu, S. Zhang, Zun-Jian Zhu, Cheng-Jian Ng, S.W. Tan, Ren-Xiang Q Science (General) Three new alkaloids, 15b-dehydro-5-N-acetylardeemin (3), 10-phenyl-[12]-cytochalasins Z16 (6) andZ17(7), were characterized from the liquid culture of the endophytic fungus Aspergillus terreus IFB-E030 along with six known derivatives, 5-N-acetylardeemin (1), 15b-beta-hydroxyl-5-N-acetylardeemin (2), cytochalasin E (4), rosellichalasin (5), cytochalasins Z11 (8), and Z13 (9). The structures of the new metabolites were established mainly by a combination of their 1D- and 2D-NMR spectra, single crystal X-ray diffraction, and the modified Mosher reaction. Biological assays indicated that cytochalasin Z17 (7) had moderate cytotoxicity against human nasopharyngeal epidermoid tumor KB cell line with an IC(50) value of 26.2 mu M. Georg Thieme Verlag Kg 2010 Article PeerReviewed Zhang, Hua-Wei and Zhang, J. and Hu, S. and Zhang, Zun-Jian and Zhu, Cheng-Jian and Ng, S.W. and Tan, Ren-Xiang (2010) Ardeemins and cytochalasins from aspergillus terreus residing in Artemisia annua. Planta Medica, 76 (14). pp. 1616-1621. |
| spellingShingle | Q Science (General) Zhang, Hua-Wei Zhang, J. Hu, S. Zhang, Zun-Jian Zhu, Cheng-Jian Ng, S.W. Tan, Ren-Xiang Ardeemins and cytochalasins from aspergillus terreus residing in Artemisia annua |
| title | Ardeemins and cytochalasins from aspergillus terreus residing in Artemisia annua |
| title_full | Ardeemins and cytochalasins from aspergillus terreus residing in Artemisia annua |
| title_fullStr | Ardeemins and cytochalasins from aspergillus terreus residing in Artemisia annua |
| title_full_unstemmed | Ardeemins and cytochalasins from aspergillus terreus residing in Artemisia annua |
| title_short | Ardeemins and cytochalasins from aspergillus terreus residing in Artemisia annua |
| title_sort | ardeemins and cytochalasins from aspergillus terreus residing in artemisia annua |
| topic | Q Science (General) |
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