Wound healing potential by hyaluronate gel in streptozotocin-induced diabetic rats

This study was conducted to investigate whether topical application of Hyaluronate gels could improve the impaired wound healing in streptozotocin-induced diabetic rats. Four groups of adult male Sprague Dawley rats, 2 cm full-thickness skin wound were experimentally created on the posterior neck ar...

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Main Authors: Al Bayaty, F., Abdulla, M., Abu Hassan, M.I., Masud, M.
Format: Article
Published: Academic Journals 2010
Subjects:
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author Al Bayaty, F.
Abdulla, M.
Abu Hassan, M.I.
Masud, M.
author_facet Al Bayaty, F.
Abdulla, M.
Abu Hassan, M.I.
Masud, M.
author_sort Al Bayaty, F.
collection UM
description This study was conducted to investigate whether topical application of Hyaluronate gels could improve the impaired wound healing in streptozotocin-induced diabetic rats. Four groups of adult male Sprague Dawley rats, 2 cm full-thickness skin wound were experimentally created on the posterior neck area of streptozotocin-induced diabetic rats (STZ). Wounds of Group 1 animals were topically treated with the vehicle, gum acacia in normal saline, as a placebo control group. Group 2 animals served as reference standard and treated topically with Intrasite gel. Animals of Group 3, 4 were treated topically with new oral high molecular weight hyaluronic acid 240 mg/100 g gel, 0.8% hyaluronic acid gel respectively. Macroscopically, the reference standard gel and the three gels-treated wounds were significantly healed faster in comparison to placebo control wounds group. Wound closure was significantly accelerated by topical application of high molecular weight hyaluronic acid compared to reference standard gel, 0.8% hyaluronic acid gel. Furthermore, histological examination of healed wounds with reference standard gel, 0.8% hyaluronic acid gel, and hyaluronic acid 240 mg/100 g gel-treated wounds revealed comparatively increases in macrophages, fibroblast migration, collagen regeneration, and epithlization compared with the placebo control group. In conclusion, the new oral high molecular weight hyaluronic acid gel can improve the impaired healing of diabetic wounds and could be useful in treating oral ulcerations.
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spelling um.eprints-123402017-05-22T06:48:52Z http://eprints.um.edu.my/12340/ Wound healing potential by hyaluronate gel in streptozotocin-induced diabetic rats Al Bayaty, F. Abdulla, M. Abu Hassan, M.I. Masud, M. Q Science (General) This study was conducted to investigate whether topical application of Hyaluronate gels could improve the impaired wound healing in streptozotocin-induced diabetic rats. Four groups of adult male Sprague Dawley rats, 2 cm full-thickness skin wound were experimentally created on the posterior neck area of streptozotocin-induced diabetic rats (STZ). Wounds of Group 1 animals were topically treated with the vehicle, gum acacia in normal saline, as a placebo control group. Group 2 animals served as reference standard and treated topically with Intrasite gel. Animals of Group 3, 4 were treated topically with new oral high molecular weight hyaluronic acid 240 mg/100 g gel, 0.8% hyaluronic acid gel respectively. Macroscopically, the reference standard gel and the three gels-treated wounds were significantly healed faster in comparison to placebo control wounds group. Wound closure was significantly accelerated by topical application of high molecular weight hyaluronic acid compared to reference standard gel, 0.8% hyaluronic acid gel. Furthermore, histological examination of healed wounds with reference standard gel, 0.8% hyaluronic acid gel, and hyaluronic acid 240 mg/100 g gel-treated wounds revealed comparatively increases in macrophages, fibroblast migration, collagen regeneration, and epithlization compared with the placebo control group. In conclusion, the new oral high molecular weight hyaluronic acid gel can improve the impaired healing of diabetic wounds and could be useful in treating oral ulcerations. Academic Journals 2010 Article PeerReviewed Al Bayaty, F. and Abdulla, M. and Abu Hassan, M.I. and Masud, M. (2010) Wound healing potential by hyaluronate gel in streptozotocin-induced diabetic rats. Scientific Research and Essays, 5 (18). pp. 2756-2760.
spellingShingle Q Science (General)
Al Bayaty, F.
Abdulla, M.
Abu Hassan, M.I.
Masud, M.
Wound healing potential by hyaluronate gel in streptozotocin-induced diabetic rats
title Wound healing potential by hyaluronate gel in streptozotocin-induced diabetic rats
title_full Wound healing potential by hyaluronate gel in streptozotocin-induced diabetic rats
title_fullStr Wound healing potential by hyaluronate gel in streptozotocin-induced diabetic rats
title_full_unstemmed Wound healing potential by hyaluronate gel in streptozotocin-induced diabetic rats
title_short Wound healing potential by hyaluronate gel in streptozotocin-induced diabetic rats
title_sort wound healing potential by hyaluronate gel in streptozotocin induced diabetic rats
topic Q Science (General)
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