Mediastinal Hepatocellular Carcinoma with Unknown Primary: An Unusual and Rare Presentation

This is an excerpt from the content Background Hepatocellular carcinoma (HCC) is a common cancer in Asia due to the high prevalence of hepatitis B and C infections in this region [1]. It often occurs in a cirrhotic liver as a sequalae of chronic hepatitis B and C infections as well as alcoholic...

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Main Authors: Koh, P.S., Yusof, M.M., Yoong, B.K., Rajadurai, P.
Format: Article
Published: Humana Press 2014
Subjects:
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author Koh, P.S.
Yusof, M.M.
Yoong, B.K.
Rajadurai, P.
author_facet Koh, P.S.
Yusof, M.M.
Yoong, B.K.
Rajadurai, P.
author_sort Koh, P.S.
collection UM
description This is an excerpt from the content Background Hepatocellular carcinoma (HCC) is a common cancer in Asia due to the high prevalence of hepatitis B and C infections in this region [1]. It often occurs in a cirrhotic liver as a sequalae of chronic hepatitis B and C infections as well as alcoholic liver or fatty liver disease. With improved treatment of HCC over the years, extrahepatic metastatic HCC are frequently reported, and its incidence is increasing [2]. Metastatic HCC has often been reported in common extrahepatic sites such as lungs, bones, lymph nodes and adrenals as a result of hematogenous or lymphatic spread as well as direct invasion of tumour tissue [3]. However, extrahepatic HCC presenting as a solitary mass is unusual when no primary liver tumour is detectable or identifiable. To our knowledge, there are numerous reports in the literature describing extrahepatic and metastatic HCC with no known primary occurring in various sites, but we report a rare case of mediastinal HCC with an unknown primary in a 46-yea ...
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spelling um.eprints-123882015-01-26T12:46:39Z http://eprints.um.edu.my/12388/ Mediastinal Hepatocellular Carcinoma with Unknown Primary: An Unusual and Rare Presentation Koh, P.S. Yusof, M.M. Yoong, B.K. Rajadurai, P. R Medicine This is an excerpt from the content Background Hepatocellular carcinoma (HCC) is a common cancer in Asia due to the high prevalence of hepatitis B and C infections in this region [1]. It often occurs in a cirrhotic liver as a sequalae of chronic hepatitis B and C infections as well as alcoholic liver or fatty liver disease. With improved treatment of HCC over the years, extrahepatic metastatic HCC are frequently reported, and its incidence is increasing [2]. Metastatic HCC has often been reported in common extrahepatic sites such as lungs, bones, lymph nodes and adrenals as a result of hematogenous or lymphatic spread as well as direct invasion of tumour tissue [3]. However, extrahepatic HCC presenting as a solitary mass is unusual when no primary liver tumour is detectable or identifiable. To our knowledge, there are numerous reports in the literature describing extrahepatic and metastatic HCC with no known primary occurring in various sites, but we report a rare case of mediastinal HCC with an unknown primary in a 46-yea ... Humana Press 2014-12 Article PeerReviewed Koh, P.S. and Yusof, M.M. and Yoong, B.K. and Rajadurai, P. (2014) Mediastinal Hepatocellular Carcinoma with Unknown Primary: An Unusual and Rare Presentation. Journal of Gastrointestinal Cancer, 45 (1). pp. 74-76. ISSN 1941-6628, DOI https://doi.org/10.1007/s12029-013-9549-8 <https://doi.org/10.1007/s12029-013-9549-8>. http://link.springer.com/article/10.1007%2Fs12029-013-9549-8 http://dx.doi.org/10.1007/s12029-013-9549-8
spellingShingle R Medicine
Koh, P.S.
Yusof, M.M.
Yoong, B.K.
Rajadurai, P.
Mediastinal Hepatocellular Carcinoma with Unknown Primary: An Unusual and Rare Presentation
title Mediastinal Hepatocellular Carcinoma with Unknown Primary: An Unusual and Rare Presentation
title_full Mediastinal Hepatocellular Carcinoma with Unknown Primary: An Unusual and Rare Presentation
title_fullStr Mediastinal Hepatocellular Carcinoma with Unknown Primary: An Unusual and Rare Presentation
title_full_unstemmed Mediastinal Hepatocellular Carcinoma with Unknown Primary: An Unusual and Rare Presentation
title_short Mediastinal Hepatocellular Carcinoma with Unknown Primary: An Unusual and Rare Presentation
title_sort mediastinal hepatocellular carcinoma with unknown primary an unusual and rare presentation
topic R Medicine
work_keys_str_mv AT kohps mediastinalhepatocellularcarcinomawithunknownprimaryanunusualandrarepresentation
AT yusofmm mediastinalhepatocellularcarcinomawithunknownprimaryanunusualandrarepresentation
AT yoongbk mediastinalhepatocellularcarcinomawithunknownprimaryanunusualandrarepresentation
AT rajaduraip mediastinalhepatocellularcarcinomawithunknownprimaryanunusualandrarepresentation