Dopamine-secreting phaeochromocytomas and paragangliomas: clinical features and management
Most functional phaeochromocytomas/paragangliomas produce noradrenaline and/or adrenaline. Those that produce dopamine are rare. We describe the distinguishing clinical features of dopamine-secreting phaeochromocytomas and paragangliomas from those that secrete noradrenaline/adrenaline and the impac...
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| Format: | Article |
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Stamford Publishing Pte Ltd / Singapore Medical Association
2010
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| _version_ | 1825718521352421376 |
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| author | Foo, S.H. Chan, S.P. Ananda, V. Rajasingam, V. |
| author_facet | Foo, S.H. Chan, S.P. Ananda, V. Rajasingam, V. |
| author_sort | Foo, S.H. |
| collection | UM |
| description | Most functional phaeochromocytomas/paragangliomas produce noradrenaline and/or adrenaline. Those that produce dopamine are rare. We describe the distinguishing clinical features of dopamine-secreting phaeochromocytomas and paragangliomas from those that secrete noradrenaline/adrenaline and the impact on their management. We present a case of a dopamine-secreting paraganglioma from our institution and review 14 case reports of dopamine-secreting phaeochromocytomas/paragangliomas published between 1984 and 2008. As observed in the literature, 80% of the tumours were extra-adrenal. Most patients presented with non-specific symptoms or mass effect without the classical presentation of catecholamine excess. The majority were diagnosed with urinary or plasma dopamine. Five patients had malignant tumours and 12 patients underwent surgical resection of the primary tumours. Unlike noradrenaline/adrenaline-secreting phaeochromocytomas/paragangliomas, dopamine-secreting tumours lack a classical presentation, are extra-adrenal and have a higher malignant potential. A routine inclusion of urinary or plasma dopamine as part of catecholamine screening in all suspected phaeochromocytomas and paragangliomas is recommended. |
| first_indexed | 2024-03-06T05:05:48Z |
| format | Article |
| id | um.eprints-1251 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:05:48Z |
| publishDate | 2010 |
| publisher | Stamford Publishing Pte Ltd / Singapore Medical Association |
| record_format | dspace |
| spelling | um.eprints-12512019-01-14T01:24:46Z http://eprints.um.edu.my/1251/ Dopamine-secreting phaeochromocytomas and paragangliomas: clinical features and management Foo, S.H. Chan, S.P. Ananda, V. Rajasingam, V. R Medicine Most functional phaeochromocytomas/paragangliomas produce noradrenaline and/or adrenaline. Those that produce dopamine are rare. We describe the distinguishing clinical features of dopamine-secreting phaeochromocytomas and paragangliomas from those that secrete noradrenaline/adrenaline and the impact on their management. We present a case of a dopamine-secreting paraganglioma from our institution and review 14 case reports of dopamine-secreting phaeochromocytomas/paragangliomas published between 1984 and 2008. As observed in the literature, 80% of the tumours were extra-adrenal. Most patients presented with non-specific symptoms or mass effect without the classical presentation of catecholamine excess. The majority were diagnosed with urinary or plasma dopamine. Five patients had malignant tumours and 12 patients underwent surgical resection of the primary tumours. Unlike noradrenaline/adrenaline-secreting phaeochromocytomas/paragangliomas, dopamine-secreting tumours lack a classical presentation, are extra-adrenal and have a higher malignant potential. A routine inclusion of urinary or plasma dopamine as part of catecholamine screening in all suspected phaeochromocytomas and paragangliomas is recommended. Stamford Publishing Pte Ltd / Singapore Medical Association 2010-05 Article PeerReviewed Foo, S.H. and Chan, S.P. and Ananda, V. and Rajasingam, V. (2010) Dopamine-secreting phaeochromocytomas and paragangliomas: clinical features and management. Singapore Medical Journal, 51 (5). e89-93. ISSN 0037-5675, DOI 20593136. http://www.ncbi.nlm.nih.gov/pubmed/20593136 20593136 |
| spellingShingle | R Medicine Foo, S.H. Chan, S.P. Ananda, V. Rajasingam, V. Dopamine-secreting phaeochromocytomas and paragangliomas: clinical features and management |
| title | Dopamine-secreting phaeochromocytomas and paragangliomas: clinical features and management |
| title_full | Dopamine-secreting phaeochromocytomas and paragangliomas: clinical features and management |
| title_fullStr | Dopamine-secreting phaeochromocytomas and paragangliomas: clinical features and management |
| title_full_unstemmed | Dopamine-secreting phaeochromocytomas and paragangliomas: clinical features and management |
| title_short | Dopamine-secreting phaeochromocytomas and paragangliomas: clinical features and management |
| title_sort | dopamine secreting phaeochromocytomas and paragangliomas clinical features and management |
| topic | R Medicine |
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