A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity
As part of the vital search towards improved therapeutic agents for the treatment of neuropathic pain, the central nervous system glutamate receptors have become a major focus of research. Outlined herein are the syntheses of two new biologically active 3'-cycloalkyl-substituted carboxycyclopro...
Main Authors: | Stanley, N.J., Hutchinson, M.R., Kvist, T., Nielsen, B., Mathiesen, J.M., Brauner-Osborne, H., Avery, T.D., Tiekink, E.R.T., Pedersen, D.S., Irvine, R., Abell, A.D., Taylor, D.K. |
---|---|
Format: | Article |
Published: |
Elsevier
2010
|
Subjects: |
Similar Items
-
Contributions of metabotropic glutamate receptors to the pathophysiology of autism
by: Auerbach, Benjamin D. (Benjamin David)
Published: (2013) -
Is metabotropic glutamate receptor 5 upregulated in prefrontal cortex in fragile X syndrome?
by: Lohith, Talakad G., et al.
Published: (2013) -
Protein kinase A directly phosphorylates metabotropic glutamate receptor 5 to modulate its function
by: Uematsu, Ken, et al.
Published: (2016) -
β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X
by: Auerbach, Benjamin D., et al.
Published: (2017) -
ß-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X
by: Auerbach, Benjamin D., et al.
Published: (2017)