Explosive HIV-1 subtype B' epidemics in Asia driven by geographic and risk group founder events
We explored the timescale, spatial spread, and risk group population structure of HIV-1 subtype B', the cause of explosive blood-borne HIV-1 epidemics among injecting drug users (IDUs) and former plasma donors (FPDs) in Asia. Sequences from FPDs in China formed a distinct monophyletic cluster w...
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| Format: | Article |
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Elsevier
2010
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| _version_ | 1796946440861253632 |
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| author | Li, Y. Uenishi, R. Hase, S. Liao, H. Li, Xiao-Jie Tsuchiura, T. Tee, K.K. Pybus, O.G. Takebe, Y. |
| author_facet | Li, Y. Uenishi, R. Hase, S. Liao, H. Li, Xiao-Jie Tsuchiura, T. Tee, K.K. Pybus, O.G. Takebe, Y. |
| author_sort | Li, Y. |
| collection | UM |
| description | We explored the timescale, spatial spread, and risk group population structure of HIV-1 subtype B', the cause of explosive blood-borne HIV-1 epidemics among injecting drug users (IDUs) and former plasma donors (FPDs) in Asia. Sequences from FPDs in China formed a distinct monophyletic cluster within subtype B'. Further analysis revealed that subtype B' was founded by a single lineage of pandemic subtype B around 1985. Subsequently, the FPD cluster appears to have derived from a single subtype B' lineage around 1991, corroborating the hypothesis that FPD outbreaks stemmed from the preceding epidemic among IDUs in Southeast Asia, most likely from the Golden-Triangle region. (C) 2010 Elsevier Inc. All rights reserved. |
| first_indexed | 2024-03-06T05:31:44Z |
| format | Article |
| id | um.eprints-12693 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:31:44Z |
| publishDate | 2010 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | um.eprints-126932015-02-11T06:34:05Z http://eprints.um.edu.my/12693/ Explosive HIV-1 subtype B' epidemics in Asia driven by geographic and risk group founder events Li, Y. Uenishi, R. Hase, S. Liao, H. Li, Xiao-Jie Tsuchiura, T. Tee, K.K. Pybus, O.G. Takebe, Y. R Medicine We explored the timescale, spatial spread, and risk group population structure of HIV-1 subtype B', the cause of explosive blood-borne HIV-1 epidemics among injecting drug users (IDUs) and former plasma donors (FPDs) in Asia. Sequences from FPDs in China formed a distinct monophyletic cluster within subtype B'. Further analysis revealed that subtype B' was founded by a single lineage of pandemic subtype B around 1985. Subsequently, the FPD cluster appears to have derived from a single subtype B' lineage around 1991, corroborating the hypothesis that FPD outbreaks stemmed from the preceding epidemic among IDUs in Southeast Asia, most likely from the Golden-Triangle region. (C) 2010 Elsevier Inc. All rights reserved. Elsevier 2010 Article PeerReviewed Li, Y. and Uenishi, R. and Hase, S. and Liao, H. and Li, Xiao-Jie and Tsuchiura, T. and Tee, K.K. and Pybus, O.G. and Takebe, Y. (2010) Explosive HIV-1 subtype B' epidemics in Asia driven by geographic and risk group founder events. Virology, 402 (2). pp. 223-227. |
| spellingShingle | R Medicine Li, Y. Uenishi, R. Hase, S. Liao, H. Li, Xiao-Jie Tsuchiura, T. Tee, K.K. Pybus, O.G. Takebe, Y. Explosive HIV-1 subtype B' epidemics in Asia driven by geographic and risk group founder events |
| title | Explosive HIV-1 subtype B' epidemics in Asia driven by geographic and risk group founder events |
| title_full | Explosive HIV-1 subtype B' epidemics in Asia driven by geographic and risk group founder events |
| title_fullStr | Explosive HIV-1 subtype B' epidemics in Asia driven by geographic and risk group founder events |
| title_full_unstemmed | Explosive HIV-1 subtype B' epidemics in Asia driven by geographic and risk group founder events |
| title_short | Explosive HIV-1 subtype B' epidemics in Asia driven by geographic and risk group founder events |
| title_sort | explosive hiv 1 subtype b epidemics in asia driven by geographic and risk group founder events |
| topic | R Medicine |
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