VIPoma syndrome: challenges in management
Vasoactive intestinal peptide-producing tumour (VIPoma) or Verner-Morrison syndrome is a very rare neuroendocrine tumour. It occurs in less than ten percent of all pancreatic islet cell tumours, and about 70 percent to 80 percent of these tumours originate from the pancreas. Diagnosis is characteris...
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| Format: | Article |
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Stamford Publishing Pte Ltd / Singapore Medical Association
2010
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| _version_ | 1825718523190575104 |
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| author | Adam, N. Lim, S.S. Ananda, V. Chan, S.P. |
| author_facet | Adam, N. Lim, S.S. Ananda, V. Chan, S.P. |
| author_sort | Adam, N. |
| collection | UM |
| description | Vasoactive intestinal peptide-producing tumour (VIPoma) or Verner-Morrison syndrome is a very rare neuroendocrine tumour. It occurs in less than ten percent of all pancreatic islet cell tumours, and about 70 percent to 80 percent of these tumours originate from the pancreas. Diagnosis is characteristically delayed. The first-line treatment is surgical. It may be curative in forty percent of patients with benign and non-metastatic disease. Palliative surgery is indicated in extensive disease, followed by conventional somatostatin analogue (octreotide) therapy. Somatostatin analogues improve hormone-mediated symptoms, reduce tumour bulk and prevent local and systemic effects. We present a female patient with VIPoma syndrome, which had metastasised to the liver at diagnosis. The patient underwent palliative Whipple procedure and subsequent cytoreductive radiofrequency ablations to her liver metastases. Unfortunately, after symptomatic improvement for three years, her disease progressed. Currently, she is on daily octreotide, achieving partial control of her symptoms. |
| first_indexed | 2024-03-06T05:05:50Z |
| format | Article |
| id | um.eprints-1272 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:05:50Z |
| publishDate | 2010 |
| publisher | Stamford Publishing Pte Ltd / Singapore Medical Association |
| record_format | dspace |
| spelling | um.eprints-12722019-01-14T01:22:09Z http://eprints.um.edu.my/1272/ VIPoma syndrome: challenges in management Adam, N. Lim, S.S. Ananda, V. Chan, S.P. R Medicine Vasoactive intestinal peptide-producing tumour (VIPoma) or Verner-Morrison syndrome is a very rare neuroendocrine tumour. It occurs in less than ten percent of all pancreatic islet cell tumours, and about 70 percent to 80 percent of these tumours originate from the pancreas. Diagnosis is characteristically delayed. The first-line treatment is surgical. It may be curative in forty percent of patients with benign and non-metastatic disease. Palliative surgery is indicated in extensive disease, followed by conventional somatostatin analogue (octreotide) therapy. Somatostatin analogues improve hormone-mediated symptoms, reduce tumour bulk and prevent local and systemic effects. We present a female patient with VIPoma syndrome, which had metastasised to the liver at diagnosis. The patient underwent palliative Whipple procedure and subsequent cytoreductive radiofrequency ablations to her liver metastases. Unfortunately, after symptomatic improvement for three years, her disease progressed. Currently, she is on daily octreotide, achieving partial control of her symptoms. Stamford Publishing Pte Ltd / Singapore Medical Association 2010-07 Article PeerReviewed Adam, N. and Lim, S.S. and Ananda, V. and Chan, S.P. (2010) VIPoma syndrome: challenges in management. Singapore Medical Journal, 51 (7). e129-32. ISSN 0037-5675, DOI 20730389. http://www.ncbi.nlm.nih.gov/pubmed/20730389 20730389 |
| spellingShingle | R Medicine Adam, N. Lim, S.S. Ananda, V. Chan, S.P. VIPoma syndrome: challenges in management |
| title | VIPoma syndrome: challenges in management |
| title_full | VIPoma syndrome: challenges in management |
| title_fullStr | VIPoma syndrome: challenges in management |
| title_full_unstemmed | VIPoma syndrome: challenges in management |
| title_short | VIPoma syndrome: challenges in management |
| title_sort | vipoma syndrome challenges in management |
| topic | R Medicine |
| work_keys_str_mv | AT adamn vipomasyndromechallengesinmanagement AT limss vipomasyndromechallengesinmanagement AT anandav vipomasyndromechallengesinmanagement AT chansp vipomasyndromechallengesinmanagement |