The open conformation of WASP regulates its nuclear localization and gene transcription in myeloid cells
Mutations in the gene encoding the Wiskott–Aldrich syndrome protein (WASP) are responsible for Wiskott–Aldrich syndrome and WASP is a major actin regulator in the cytoplasm. Although rare gain-of-function mutations in the WASP gene are known to result in X-linked neutropenia (XLN), the molecular pat...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Published: |
Oxford University Press
2014
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| Subjects: |