Bisnicalaterines B and C, atropisomeric bisindole alkaloids from hunteria zeylanica, showing vasorelaxant activity
Two new bisindole alkaloids, bisnicalaterines B and C (1 and 2) consisting of an eburnane and a corynanthe type of skeletons, were isolated from the bark of Hunteria zeylanica. Their absolute structures were determined by combination of NMR, CD, and computational methods, and each of them was shown...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Artículo |
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American Chemical Society
2010
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| Materias: |
| _version_ | 1825720313757827072 |
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| author | Hirasawa, Y. Hara, M. Nugroho, A.E. Sugai, M. Zaima, K. Kawahara, N. Goda, Y. Awang, K. Hadi, A.H.A. Litaudon, M. Morita, H. |
| author_facet | Hirasawa, Y. Hara, M. Nugroho, A.E. Sugai, M. Zaima, K. Kawahara, N. Goda, Y. Awang, K. Hadi, A.H.A. Litaudon, M. Morita, H. |
| author_sort | Hirasawa, Y. |
| collection | UM |
| description | Two new bisindole alkaloids, bisnicalaterines B and C (1 and 2) consisting of an eburnane and a corynanthe type of skeletons, were isolated from the bark of Hunteria zeylanica. Their absolute structures were determined by combination of NMR, CD, and computational methods, and each of them was shown to be in an atropisomeric relationship. Bisnicalaterines B and C (1 and 2) showed potent vasorelaxant activity on isolated rat aorta. |
| first_indexed | 2024-03-06T05:33:14Z |
| format | Article |
| id | um.eprints-13222 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:33:14Z |
| publishDate | 2010 |
| publisher | American Chemical Society |
| record_format | dspace |
| spelling | um.eprints-132222015-04-07T08:45:19Z http://eprints.um.edu.my/13222/ Bisnicalaterines B and C, atropisomeric bisindole alkaloids from hunteria zeylanica, showing vasorelaxant activity Hirasawa, Y. Hara, M. Nugroho, A.E. Sugai, M. Zaima, K. Kawahara, N. Goda, Y. Awang, K. Hadi, A.H.A. Litaudon, M. Morita, H. R Medicine Two new bisindole alkaloids, bisnicalaterines B and C (1 and 2) consisting of an eburnane and a corynanthe type of skeletons, were isolated from the bark of Hunteria zeylanica. Their absolute structures were determined by combination of NMR, CD, and computational methods, and each of them was shown to be in an atropisomeric relationship. Bisnicalaterines B and C (1 and 2) showed potent vasorelaxant activity on isolated rat aorta. American Chemical Society 2010 Article PeerReviewed Hirasawa, Y. and Hara, M. and Nugroho, A.E. and Sugai, M. and Zaima, K. and Kawahara, N. and Goda, Y. and Awang, K. and Hadi, A.H.A. and Litaudon, M. and Morita, H. (2010) Bisnicalaterines B and C, atropisomeric bisindole alkaloids from hunteria zeylanica, showing vasorelaxant activity. The Journal of Organic Chemistry, 75 (12). pp. 4218-4223. |
| spellingShingle | R Medicine Hirasawa, Y. Hara, M. Nugroho, A.E. Sugai, M. Zaima, K. Kawahara, N. Goda, Y. Awang, K. Hadi, A.H.A. Litaudon, M. Morita, H. Bisnicalaterines B and C, atropisomeric bisindole alkaloids from hunteria zeylanica, showing vasorelaxant activity |
| title | Bisnicalaterines B and C, atropisomeric bisindole alkaloids from hunteria zeylanica, showing vasorelaxant activity |
| title_full | Bisnicalaterines B and C, atropisomeric bisindole alkaloids from hunteria zeylanica, showing vasorelaxant activity |
| title_fullStr | Bisnicalaterines B and C, atropisomeric bisindole alkaloids from hunteria zeylanica, showing vasorelaxant activity |
| title_full_unstemmed | Bisnicalaterines B and C, atropisomeric bisindole alkaloids from hunteria zeylanica, showing vasorelaxant activity |
| title_short | Bisnicalaterines B and C, atropisomeric bisindole alkaloids from hunteria zeylanica, showing vasorelaxant activity |
| title_sort | bisnicalaterines b and c atropisomeric bisindole alkaloids from hunteria zeylanica showing vasorelaxant activity |
| topic | R Medicine |
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