Solubility of isoniazid in supercritical carbon dioxide
Solubility data of isoniazid in supercritical carbon dioxide are important in selecting the most appropriate supercritical methods for pharmaceutical material processing, such as the micronization of isoniazid or the production of isoniazid composites. The solubility of isoniazid in supercritical ca...
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| Format: | Article |
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American Chemical Society
2010
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| author | Heryanto, Rudi Abdullah, Ezzat Chan Hasan, Masitah |
| author_facet | Heryanto, Rudi Abdullah, Ezzat Chan Hasan, Masitah |
| author_sort | Heryanto, Rudi |
| collection | UM |
| description | Solubility data of isoniazid in supercritical carbon dioxide are important in selecting the most appropriate supercritical methods for pharmaceutical material processing, such as the micronization of isoniazid or the production of isoniazid composites. The solubility of isoniazid in supercritical carbon dioxide was measured using a dynamic analytical method at temperatures of (308, 311, and 313) K and pressures ranging from (13.0 to 18.5) MPa. The result showed that isoniazid solubility increased with the increase of pressure at an isothermal condition and it also increased with the increase of temperature. The experimental data were correlated using the Chrastil and Mendez-Santiago and Teja models. The calculated results show good agreement with the experimental data. |
| first_indexed | 2024-03-06T05:33:36Z |
| format | Article |
| id | um.eprints-13364 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:33:36Z |
| publishDate | 2010 |
| publisher | American Chemical Society |
| record_format | dspace |
| spelling | um.eprints-133642019-05-31T04:23:19Z http://eprints.um.edu.my/13364/ Solubility of isoniazid in supercritical carbon dioxide Heryanto, Rudi Abdullah, Ezzat Chan Hasan, Masitah Q Science (General) Solubility data of isoniazid in supercritical carbon dioxide are important in selecting the most appropriate supercritical methods for pharmaceutical material processing, such as the micronization of isoniazid or the production of isoniazid composites. The solubility of isoniazid in supercritical carbon dioxide was measured using a dynamic analytical method at temperatures of (308, 311, and 313) K and pressures ranging from (13.0 to 18.5) MPa. The result showed that isoniazid solubility increased with the increase of pressure at an isothermal condition and it also increased with the increase of temperature. The experimental data were correlated using the Chrastil and Mendez-Santiago and Teja models. The calculated results show good agreement with the experimental data. American Chemical Society 2010 Article PeerReviewed Heryanto, Rudi and Abdullah, Ezzat Chan and Hasan, Masitah (2010) Solubility of isoniazid in supercritical carbon dioxide. Journal of Chemical and Engineering Data, 55 (6). pp. 2306-2309. ISSN 0021-9568, DOI https://doi.org/10.1021/je900622h <https://doi.org/10.1021/je900622h>. https://doi.org/10.1021/je900622h doi:10.1021/je900622h |
| spellingShingle | Q Science (General) Heryanto, Rudi Abdullah, Ezzat Chan Hasan, Masitah Solubility of isoniazid in supercritical carbon dioxide |
| title | Solubility of isoniazid in supercritical carbon dioxide |
| title_full | Solubility of isoniazid in supercritical carbon dioxide |
| title_fullStr | Solubility of isoniazid in supercritical carbon dioxide |
| title_full_unstemmed | Solubility of isoniazid in supercritical carbon dioxide |
| title_short | Solubility of isoniazid in supercritical carbon dioxide |
| title_sort | solubility of isoniazid in supercritical carbon dioxide |
| topic | Q Science (General) |
| work_keys_str_mv | AT heryantorudi solubilityofisoniazidinsupercriticalcarbondioxide AT abdullahezzatchan solubilityofisoniazidinsupercriticalcarbondioxide AT hasanmasitah solubilityofisoniazidinsupercriticalcarbondioxide |