Melioidosis in Malaysia
Melioidosis is an important cause of sepsis in the tropics, is caused by an environmental saprophyte--B. pseudomallei. It affects mainly adults with underlying predisposing condition such as diabetes. The range of symptoms varies from benign and localized abscesses, to severe community-acquired pneu...
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| Format: | Article |
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Malaysian Medical Association
2009
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| _version_ | 1825718529096155136 |
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| author | Puthucheary, Savithri Devi |
| author_facet | Puthucheary, Savithri Devi |
| author_sort | Puthucheary, Savithri Devi |
| collection | UM |
| description | Melioidosis is an important cause of sepsis in the tropics, is caused by an environmental saprophyte--B. pseudomallei. It affects mainly adults with underlying predisposing condition such as diabetes. The range of symptoms varies from benign and localized abscesses, to severe community-acquired pneumonia to acute fulminating septicaemia with multiple abscesses often leading to death. B. pseudomallei is an intracellular pathogen and some of the virulence mechanisms that govern the complex interaction between the organism and the host have been elucidated. Isolation of B. pseudomallei from bodily fluids of patients remains the "gold standard" in diagnosis but a sensitive and specific serological test can lend support to the diagnosis of melioidosis. Ceftazidime is the treatment of choice for severe melioidosis, but the response is slow. Maintenance or eradication therapy for a prolonged period is necessary to prevent relapse and recurrence. Monitoring IgG antibody levels may be useful as a guideline to determine the duration of eradication therapy. |
| first_indexed | 2024-03-06T05:05:55Z |
| format | Article |
| id | um.eprints-1337 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:05:55Z |
| publishDate | 2009 |
| publisher | Malaysian Medical Association |
| record_format | dspace |
| spelling | um.eprints-13372020-10-16T03:33:08Z http://eprints.um.edu.my/1337/ Melioidosis in Malaysia Puthucheary, Savithri Devi R Medicine Melioidosis is an important cause of sepsis in the tropics, is caused by an environmental saprophyte--B. pseudomallei. It affects mainly adults with underlying predisposing condition such as diabetes. The range of symptoms varies from benign and localized abscesses, to severe community-acquired pneumonia to acute fulminating septicaemia with multiple abscesses often leading to death. B. pseudomallei is an intracellular pathogen and some of the virulence mechanisms that govern the complex interaction between the organism and the host have been elucidated. Isolation of B. pseudomallei from bodily fluids of patients remains the "gold standard" in diagnosis but a sensitive and specific serological test can lend support to the diagnosis of melioidosis. Ceftazidime is the treatment of choice for severe melioidosis, but the response is slow. Maintenance or eradication therapy for a prolonged period is necessary to prevent relapse and recurrence. Monitoring IgG antibody levels may be useful as a guideline to determine the duration of eradication therapy. Malaysian Medical Association 2009-12 Article PeerReviewed Puthucheary, Savithri Devi (2009) Melioidosis in Malaysia. Medical Journal of Malaysia, 64 (4). pp. 266-274. ISSN 0300-5283, DOI 20954549. http://www.e-mjm.org/2009/v64n4/Melioidosis.pdf 20954549 |
| spellingShingle | R Medicine Puthucheary, Savithri Devi Melioidosis in Malaysia |
| title | Melioidosis in Malaysia |
| title_full | Melioidosis in Malaysia |
| title_fullStr | Melioidosis in Malaysia |
| title_full_unstemmed | Melioidosis in Malaysia |
| title_short | Melioidosis in Malaysia |
| title_sort | melioidosis in malaysia |
| topic | R Medicine |
| work_keys_str_mv | AT puthuchearysavithridevi melioidosisinmalaysia |