Development of novel passive check valves for the microfluidic CD platfor
Microfluidic CD platforms are utilized to perform different biological processes and chemical analyses. In general, a microfluidic CD implements the centrifugal force that is created by the spinning of the platform to pump liquid through the microfluidic network of chambers and channels. Over the la...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/13820/1/Development_of_novel_passive_check_valves_for_the_microfluidic.pdf |
| _version_ | 1825720421331238912 |
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| author | Al-Faqheri, W. Ibrahim, Fatimah Thio, T.H.G. Aeinehvand, M.M. Arof, Hamzah Madou, M. |
| author_facet | Al-Faqheri, W. Ibrahim, Fatimah Thio, T.H.G. Aeinehvand, M.M. Arof, Hamzah Madou, M. |
| author_sort | Al-Faqheri, W. |
| collection | UM |
| description | Microfluidic CD platforms are utilized to perform different biological processes and chemical analyses. In general, a microfluidic CD implements the centrifugal force that is created by the spinning of the platform to pump liquid through the microfluidic network of chambers and channels. Over the last few decades, a wide range of active and passive valving methods were proposed and tested on various microfluidic platforms. Most of the presented valves are too complex to design and involve lengthy fabrication processes. In this paper, easy to fabricate air and liquid check valves for centrifugal microfluidic platforms are presented: a Terminal Check Valve (TCV) and a Bridge Check Valve (BCV). To understand the characteristic of the proposed valves, theoretical and experimental studies are conducted. Moreover, to test the effectiveness of these valves, liquid swapping is demonstrated by integrating TCV and BCV chips with thermo-pneumatic (TA) pumping on a CD. The valves are shown to accurately control flow direction which makes them an excellent choice for a variety of complex microfluidic processes. The experimental and theoretical results also indicate that these valves require low pressure for actuation. Furthermore, the theoretical results confirm the ability to adjust the required actuation pressure by changing the valve chip size. Finally, as a proof of concept for implementing the check valves on a biological application, an enzyme linked immunosorbent assays (ELISA) is performed. The result shows that the TOT and BCV valving chips enhance the operating range of the processes that can be performed on the microfluidic CD. (C) 2014 Elsevier B.V. All rights reserved. |
| first_indexed | 2024-03-06T05:34:53Z |
| format | Article |
| id | um.eprints-13820 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:34:53Z |
| publishDate | 2015 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | um.eprints-138202019-01-02T03:05:09Z http://eprints.um.edu.my/13820/ Development of novel passive check valves for the microfluidic CD platfor Al-Faqheri, W. Ibrahim, Fatimah Thio, T.H.G. Aeinehvand, M.M. Arof, Hamzah Madou, M. T Technology (General) TA Engineering (General). Civil engineering (General) TK Electrical engineering. Electronics Nuclear engineering Microfluidic CD platforms are utilized to perform different biological processes and chemical analyses. In general, a microfluidic CD implements the centrifugal force that is created by the spinning of the platform to pump liquid through the microfluidic network of chambers and channels. Over the last few decades, a wide range of active and passive valving methods were proposed and tested on various microfluidic platforms. Most of the presented valves are too complex to design and involve lengthy fabrication processes. In this paper, easy to fabricate air and liquid check valves for centrifugal microfluidic platforms are presented: a Terminal Check Valve (TCV) and a Bridge Check Valve (BCV). To understand the characteristic of the proposed valves, theoretical and experimental studies are conducted. Moreover, to test the effectiveness of these valves, liquid swapping is demonstrated by integrating TCV and BCV chips with thermo-pneumatic (TA) pumping on a CD. The valves are shown to accurately control flow direction which makes them an excellent choice for a variety of complex microfluidic processes. The experimental and theoretical results also indicate that these valves require low pressure for actuation. Furthermore, the theoretical results confirm the ability to adjust the required actuation pressure by changing the valve chip size. Finally, as a proof of concept for implementing the check valves on a biological application, an enzyme linked immunosorbent assays (ELISA) is performed. The result shows that the TOT and BCV valving chips enhance the operating range of the processes that can be performed on the microfluidic CD. (C) 2014 Elsevier B.V. All rights reserved. Elsevier 2015-02-01 Article PeerReviewed application/pdf en http://eprints.um.edu.my/13820/1/Development_of_novel_passive_check_valves_for_the_microfluidic.pdf Al-Faqheri, W. and Ibrahim, Fatimah and Thio, T.H.G. and Aeinehvand, M.M. and Arof, Hamzah and Madou, M. (2015) Development of novel passive check valves for the microfluidic CD platfor. Sensors and Actuators A: Physical, 222. pp. 245-254. ISSN 0924-4247, DOI https://doi.org/10.1016/j.sna.2014.12.018 <https://doi.org/10.1016/j.sna.2014.12.018>. http://www.sciencedirect.com/science/article/pii/S0924424714005408 DOI 10.1016/j.sna.2014.12.018 |
| spellingShingle | T Technology (General) TA Engineering (General). Civil engineering (General) TK Electrical engineering. Electronics Nuclear engineering Al-Faqheri, W. Ibrahim, Fatimah Thio, T.H.G. Aeinehvand, M.M. Arof, Hamzah Madou, M. Development of novel passive check valves for the microfluidic CD platfor |
| title | Development of novel passive check valves for the microfluidic CD platfor |
| title_full | Development of novel passive check valves for the microfluidic CD platfor |
| title_fullStr | Development of novel passive check valves for the microfluidic CD platfor |
| title_full_unstemmed | Development of novel passive check valves for the microfluidic CD platfor |
| title_short | Development of novel passive check valves for the microfluidic CD platfor |
| title_sort | development of novel passive check valves for the microfluidic cd platfor |
| topic | T Technology (General) TA Engineering (General). Civil engineering (General) TK Electrical engineering. Electronics Nuclear engineering |
| url | http://eprints.um.edu.my/13820/1/Development_of_novel_passive_check_valves_for_the_microfluidic.pdf |
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