Myelodysplastic syndrome: a review from University Hospital, Kuala Lumpur
Twenty patients with Myelodysplastic Syndrome (MDS) were diagnosed in University Hospital, Kuala Lumpur over a 5 year period. They were subclassified using the French American British (FAB) criteria. 90% of the patients were above 40 years old and the sex ratio was about equal. The predominant prese...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Published: |
Stamford Publishing Pte Ltd / Singapore Medical Association
1990
|
| Subjects: |
| _version_ | 1825718534764756992 |
|---|---|
| author | Ng, S.C. Kuperan, P. Bosco, J. Menaka, N. |
| author_facet | Ng, S.C. Kuperan, P. Bosco, J. Menaka, N. |
| author_sort | Ng, S.C. |
| collection | UM |
| description | Twenty patients with Myelodysplastic Syndrome (MDS) were diagnosed in University Hospital, Kuala Lumpur over a 5 year period. They were subclassified using the French American British (FAB) criteria. 90% of the patients were above 40 years old and the sex ratio was about equal. The predominant presenting symptom was anaemia and there was paucity of physical signs at presentation. Patients with 'aggressive' subtypes of MDS i.e. refractory anaemia with excess blasts (RAEB), refractory anaemia with excess blasts in transformation (RAEB(-)+) and chronic myelomonocytic leukaemia (CMML) had more frequent thrombocytopenia and neutropenia and their marrow pictures frequently had dysmegakaryopoiesis and dysgranulopoiesis as compared to more the "benign" subtypes i.e. refractory anaemia (RA) and refractory leukaemic anaemia with ringed sideroblasts (RARS). Four patients had leukaemic transformation and all of them came from the 'aggressive' subtypes. The current views on treatment of MDS are discussed. |
| first_indexed | 2024-03-06T05:05:59Z |
| format | Article |
| id | um.eprints-1387 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:05:59Z |
| publishDate | 1990 |
| publisher | Stamford Publishing Pte Ltd / Singapore Medical Association |
| record_format | dspace |
| spelling | um.eprints-13872019-01-14T01:26:22Z http://eprints.um.edu.my/1387/ Myelodysplastic syndrome: a review from University Hospital, Kuala Lumpur Ng, S.C. Kuperan, P. Bosco, J. Menaka, N. R Medicine Twenty patients with Myelodysplastic Syndrome (MDS) were diagnosed in University Hospital, Kuala Lumpur over a 5 year period. They were subclassified using the French American British (FAB) criteria. 90% of the patients were above 40 years old and the sex ratio was about equal. The predominant presenting symptom was anaemia and there was paucity of physical signs at presentation. Patients with 'aggressive' subtypes of MDS i.e. refractory anaemia with excess blasts (RAEB), refractory anaemia with excess blasts in transformation (RAEB(-)+) and chronic myelomonocytic leukaemia (CMML) had more frequent thrombocytopenia and neutropenia and their marrow pictures frequently had dysmegakaryopoiesis and dysgranulopoiesis as compared to more the "benign" subtypes i.e. refractory anaemia (RA) and refractory leukaemic anaemia with ringed sideroblasts (RARS). Four patients had leukaemic transformation and all of them came from the 'aggressive' subtypes. The current views on treatment of MDS are discussed. Stamford Publishing Pte Ltd / Singapore Medical Association 1990-04 Article PeerReviewed Ng, S.C. and Kuperan, P. and Bosco, J. and Menaka, N. (1990) Myelodysplastic syndrome: a review from University Hospital, Kuala Lumpur. Singapore Medical Journal, 31 (2). pp. 153-8. ISSN 0037-5675, DOI 2196685. http://www.ncbi.nlm.nih.gov/pubmed/2196685 2196685 |
| spellingShingle | R Medicine Ng, S.C. Kuperan, P. Bosco, J. Menaka, N. Myelodysplastic syndrome: a review from University Hospital, Kuala Lumpur |
| title | Myelodysplastic syndrome: a review from University Hospital, Kuala Lumpur |
| title_full | Myelodysplastic syndrome: a review from University Hospital, Kuala Lumpur |
| title_fullStr | Myelodysplastic syndrome: a review from University Hospital, Kuala Lumpur |
| title_full_unstemmed | Myelodysplastic syndrome: a review from University Hospital, Kuala Lumpur |
| title_short | Myelodysplastic syndrome: a review from University Hospital, Kuala Lumpur |
| title_sort | myelodysplastic syndrome a review from university hospital kuala lumpur |
| topic | R Medicine |
| work_keys_str_mv | AT ngsc myelodysplasticsyndromeareviewfromuniversityhospitalkualalumpur AT kuperanp myelodysplasticsyndromeareviewfromuniversityhospitalkualalumpur AT boscoj myelodysplasticsyndromeareviewfromuniversityhospitalkualalumpur AT menakan myelodysplasticsyndromeareviewfromuniversityhospitalkualalumpur |