Molecular Dynamics and Docking of Biphenyl: A Potential Attachment Inhibitor for HIV-1 gp120 Glycoprotein
Purpose: To develop a new drug that inhibits viral attachment and entry for the treatment of HIV/AIDS patients. Methods: Two Protein Databank (PDB) crystal structures of HIV-1 gp120-CD4 complexes, namely, 1RZK and 1G9N, were mutated at amino acid position 43 to a biphenylalanine (biPhe-43) residu...
Main Authors: | Teow, C.T., Ismail, Salmah, Jung, M.T. |
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Format: | Article |
Published: |
Pharmacotherapy Group, University of Benin, Benin City
2014
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Subjects: |
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