An in-vitro study on the proliferative potential of rat bone marrow stem cells on electrospun fibrous polycaprolactone scaffolds containing micro-hydroxyapatite particles
Hydroxyapatite has a chemical composition that closely resembles the mineral phase of natural hard tissues, making it a good material for use as a bone scaffold. Previous studies have demonstrated that the use of electrospun nanofibres that contain synthetic hydroxyapatite aids in bone regeneration....
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| Format: | Article |
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Maney Publishing
2014
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| author | Akram, H. Azari, P. Wan Abas, Wan Abu Bakar Zain, N.M. Gan, S.N. Yahya, R. Wong, C.S. Pingguan-Murphy, Belinda |
| author_facet | Akram, H. Azari, P. Wan Abas, Wan Abu Bakar Zain, N.M. Gan, S.N. Yahya, R. Wong, C.S. Pingguan-Murphy, Belinda |
| author_sort | Akram, H. |
| collection | UM |
| description | Hydroxyapatite has a chemical composition that closely resembles the mineral phase of natural hard tissues, making it a good material for use as a bone scaffold. Previous studies have demonstrated that the use of electrospun nanofibres that contain synthetic hydroxyapatite aids in bone regeneration. In this study, composite scaffolds of polycaprolactone and bovine-derived hydroxyapatite were produced by mixing bovine-derived hydroxyapatite powder into polycaprolactone solution, followed by electrospinning. Field emission scanning electron microscopy images show that the scaffolds contained an interconnected spheroidal porous network. Four groups of scaffolds containing different weight percentages of bovine-derived hydroxyapatite (0, 10, 30 and 50%) were prepared. The scaffolds were characterised by infrared spectroscopy and field emission scanning electron microscopy which was used to observe cell attachment to the scaffolds as well. |
| first_indexed | 2024-03-06T05:38:58Z |
| format | Article |
| id | um.eprints-15496 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:38:58Z |
| publishDate | 2014 |
| publisher | Maney Publishing |
| record_format | dspace |
| spelling | um.eprints-154962020-02-10T08:34:28Z http://eprints.um.edu.my/15496/ An in-vitro study on the proliferative potential of rat bone marrow stem cells on electrospun fibrous polycaprolactone scaffolds containing micro-hydroxyapatite particles Akram, H. Azari, P. Wan Abas, Wan Abu Bakar Zain, N.M. Gan, S.N. Yahya, R. Wong, C.S. Pingguan-Murphy, Belinda Q Science (General) Hydroxyapatite has a chemical composition that closely resembles the mineral phase of natural hard tissues, making it a good material for use as a bone scaffold. Previous studies have demonstrated that the use of electrospun nanofibres that contain synthetic hydroxyapatite aids in bone regeneration. In this study, composite scaffolds of polycaprolactone and bovine-derived hydroxyapatite were produced by mixing bovine-derived hydroxyapatite powder into polycaprolactone solution, followed by electrospinning. Field emission scanning electron microscopy images show that the scaffolds contained an interconnected spheroidal porous network. Four groups of scaffolds containing different weight percentages of bovine-derived hydroxyapatite (0, 10, 30 and 50%) were prepared. The scaffolds were characterised by infrared spectroscopy and field emission scanning electron microscopy which was used to observe cell attachment to the scaffolds as well. Maney Publishing 2014 Article PeerReviewed Akram, H. and Azari, P. and Wan Abas, Wan Abu Bakar and Zain, N.M. and Gan, S.N. and Yahya, R. and Wong, C.S. and Pingguan-Murphy, Belinda (2014) An in-vitro study on the proliferative potential of rat bone marrow stem cells on electrospun fibrous polycaprolactone scaffolds containing micro-hydroxyapatite particles. Materials Research Innovations, 18 (S6). pp. 520-524. |
| spellingShingle | Q Science (General) Akram, H. Azari, P. Wan Abas, Wan Abu Bakar Zain, N.M. Gan, S.N. Yahya, R. Wong, C.S. Pingguan-Murphy, Belinda An in-vitro study on the proliferative potential of rat bone marrow stem cells on electrospun fibrous polycaprolactone scaffolds containing micro-hydroxyapatite particles |
| title | An in-vitro study on the proliferative potential of rat bone marrow stem cells on electrospun fibrous polycaprolactone scaffolds containing micro-hydroxyapatite particles |
| title_full | An in-vitro study on the proliferative potential of rat bone marrow stem cells on electrospun fibrous polycaprolactone scaffolds containing micro-hydroxyapatite particles |
| title_fullStr | An in-vitro study on the proliferative potential of rat bone marrow stem cells on electrospun fibrous polycaprolactone scaffolds containing micro-hydroxyapatite particles |
| title_full_unstemmed | An in-vitro study on the proliferative potential of rat bone marrow stem cells on electrospun fibrous polycaprolactone scaffolds containing micro-hydroxyapatite particles |
| title_short | An in-vitro study on the proliferative potential of rat bone marrow stem cells on electrospun fibrous polycaprolactone scaffolds containing micro-hydroxyapatite particles |
| title_sort | in vitro study on the proliferative potential of rat bone marrow stem cells on electrospun fibrous polycaprolactone scaffolds containing micro hydroxyapatite particles |
| topic | Q Science (General) |
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