Electrospun biopolyesters as drug screening platforms for corneal keratocytes
In vitro drug screening techniques provide rapid and easy to analyze data, while saving a lot of animals from being sacrificed. An important part of any in vitro drug screening platform is a biomaterial which promotes cell growth and proliferation. The potential of electrospun scaffolds made of poly...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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2015
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| Online Access: | http://eprints.um.edu.my/15740/1/Electrospun_Biopolyesters_as_Drug_Screening_Platforms_for_Corneal_Keratocytes.pdf |
| _version_ | 1796946951872184320 |
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| author | Azari, P. Luan, N.S. Gan, S.N. Yahya, R. Wong, C.S. Chua, K.H. Pingguan-Murphy, Belinda |
| author_facet | Azari, P. Luan, N.S. Gan, S.N. Yahya, R. Wong, C.S. Chua, K.H. Pingguan-Murphy, Belinda |
| author_sort | Azari, P. |
| collection | UM |
| description | In vitro drug screening techniques provide rapid and easy to analyze data, while saving a lot of animals from being sacrificed. An important part of any in vitro drug screening platform is a biomaterial which promotes cell growth and proliferation. The potential of electrospun scaffolds made of polyhydroxybutyrate (PHB), poly (3-hydroxybutyric acid-co-3-hydroxyvaleric acid) (PHBV), and polycaprolactone (PCL) were studied to serve as drug screening platform for corneal keratocyte tissues. The results showed that the proliferation rate was slightly higher for PCL and PHBV on day 7. Gene expression results showed that PCL was the best in maintaining keratocyte genes. GRAPHICS . |
| first_indexed | 2024-03-06T05:39:32Z |
| format | Article |
| id | um.eprints-15740 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:39:32Z |
| publishDate | 2015 |
| record_format | dspace |
| spelling | um.eprints-157402020-02-10T08:37:48Z http://eprints.um.edu.my/15740/ Electrospun biopolyesters as drug screening platforms for corneal keratocytes Azari, P. Luan, N.S. Gan, S.N. Yahya, R. Wong, C.S. Chua, K.H. Pingguan-Murphy, Belinda T Technology (General) TA Engineering (General). Civil engineering (General) In vitro drug screening techniques provide rapid and easy to analyze data, while saving a lot of animals from being sacrificed. An important part of any in vitro drug screening platform is a biomaterial which promotes cell growth and proliferation. The potential of electrospun scaffolds made of polyhydroxybutyrate (PHB), poly (3-hydroxybutyric acid-co-3-hydroxyvaleric acid) (PHBV), and polycaprolactone (PCL) were studied to serve as drug screening platform for corneal keratocyte tissues. The results showed that the proliferation rate was slightly higher for PCL and PHBV on day 7. Gene expression results showed that PCL was the best in maintaining keratocyte genes. GRAPHICS . 2015 Article PeerReviewed application/pdf en http://eprints.um.edu.my/15740/1/Electrospun_Biopolyesters_as_Drug_Screening_Platforms_for_Corneal_Keratocytes.pdf Azari, P. and Luan, N.S. and Gan, S.N. and Yahya, R. and Wong, C.S. and Chua, K.H. and Pingguan-Murphy, Belinda (2015) Electrospun biopolyesters as drug screening platforms for corneal keratocytes. International Journal of Polymeric Materials and Polymeric Biomaterials, 64 (15). pp. 785-791. ISSN 0091-4037, DOI https://doi.org/10.1080/00914037.2015.1030648 <https://doi.org/10.1080/00914037.2015.1030648>. http://www.tandfonline.com/doi/pdf/10.1080/00914037.2015.1030648 10.1080/00914037.2015.1030648 |
| spellingShingle | T Technology (General) TA Engineering (General). Civil engineering (General) Azari, P. Luan, N.S. Gan, S.N. Yahya, R. Wong, C.S. Chua, K.H. Pingguan-Murphy, Belinda Electrospun biopolyesters as drug screening platforms for corneal keratocytes |
| title | Electrospun biopolyesters as drug screening platforms for corneal keratocytes |
| title_full | Electrospun biopolyesters as drug screening platforms for corneal keratocytes |
| title_fullStr | Electrospun biopolyesters as drug screening platforms for corneal keratocytes |
| title_full_unstemmed | Electrospun biopolyesters as drug screening platforms for corneal keratocytes |
| title_short | Electrospun biopolyesters as drug screening platforms for corneal keratocytes |
| title_sort | electrospun biopolyesters as drug screening platforms for corneal keratocytes |
| topic | T Technology (General) TA Engineering (General). Civil engineering (General) |
| url | http://eprints.um.edu.my/15740/1/Electrospun_Biopolyesters_as_Drug_Screening_Platforms_for_Corneal_Keratocytes.pdf |
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