Biologically active flavonoids from Dodonaea viscosa and their structure-activity relationships
Antioxidant and anticholinesterase activities of twelve flavonoids i.e. santin (1), penduletin (2), viscosine (3), 6,7-dimethylkaempferol (4), kaempferol-3- methylether (5), 3,4'-dimethoxy-5,7-dihydroxyflavone (6), 5,7,4'-trihydroxy-3-(3-hydroxymethylbutyl)-3,6-dimethoxyflavone (7), 5,7-di...
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Elsevier
2015
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author | Muhammad, A. Tel-Cayan, G. Ozturk, M. Nadeem, S. Duru, M.E. Anis, I. Ng, S.W. Shah, M.R. |
author_facet | Muhammad, A. Tel-Cayan, G. Ozturk, M. Nadeem, S. Duru, M.E. Anis, I. Ng, S.W. Shah, M.R. |
author_sort | Muhammad, A. |
collection | UM |
description | Antioxidant and anticholinesterase activities of twelve flavonoids i.e. santin (1), penduletin (2), viscosine (3), 6,7-dimethylkaempferol (4), kaempferol-3- methylether (5), 3,4'-dimethoxy-5,7-dihydroxyflavone (6), 5,7,4'-trihydroxy-3-(3-hydroxymethylbutyl)-3,6-dimethoxyflavone (7), 5,7-dihydroxy-3'-(2-hydroxy-3-methyl-3-butenyl)-3,6,4'-trimethoxy-flavon e (8), 5,7-dihydroxy-3'-(3-hydroxy-methylbutyl)-3,6,4'-trimethoxyflavone (9), 5,7-dihydroxy-3'-(4 `'-acetoxy-3''-methylbuty1)-3,6,4'-trimethoxy flavone (10), aromadendrin, (2S,3S) 3,4',5,7-tetrahydroxyflavanone (11), and pinocembrin (12), together with monohydrated crystal (1A) of 1 and anhydrous crystal (3A) of 3 - isolated from Dodonaea viscosa - were studied. The results are given as 50% inhibition concentrations (IC50). Their structure-activity relationships are discussed for both activities. Flavonoids 3 and 10 showed higher antioxidant activity in all tests. 3 Also showed moderate acetylcholinesterase (IC50: 182.97 +/- 1.25 mu M) and significant butyrylcholinesterase (IC50: 47.07 +/- 0.54 mu M) inhibitory activities. Compounds 2 (IC50: 55.78 +/- 1.01 mu M) and 3A (IC50: 58.72 +/- 1.02 mu M) were also moderate anticholinesterase agents against butyrylcholinesterase enzyme. Monohydrate crystal (1A) showed better antioxidant and anticholinesterase activities than its amorphous form (1). In contrast, the amorphous 3 exhibited better activity than the anhydrous crystal (3A). In hydrous crystal, the water molecule might be responsible for better activity. These natural flavonoids can be used as pharmaceuticals and/or preservatives in respective industries. (C) 2015 Elsevier B.V. All rights reserved. |
first_indexed | 2024-03-06T05:40:12Z |
format | Article |
id | um.eprints-16065 |
institution | Universiti Malaya |
last_indexed | 2024-03-06T05:40:12Z |
publishDate | 2015 |
publisher | Elsevier |
record_format | dspace |
spelling | um.eprints-160652019-03-20T08:07:10Z http://eprints.um.edu.my/16065/ Biologically active flavonoids from Dodonaea viscosa and their structure-activity relationships Muhammad, A. Tel-Cayan, G. Ozturk, M. Nadeem, S. Duru, M.E. Anis, I. Ng, S.W. Shah, M.R. S Agriculture (General) Antioxidant and anticholinesterase activities of twelve flavonoids i.e. santin (1), penduletin (2), viscosine (3), 6,7-dimethylkaempferol (4), kaempferol-3- methylether (5), 3,4'-dimethoxy-5,7-dihydroxyflavone (6), 5,7,4'-trihydroxy-3-(3-hydroxymethylbutyl)-3,6-dimethoxyflavone (7), 5,7-dihydroxy-3'-(2-hydroxy-3-methyl-3-butenyl)-3,6,4'-trimethoxy-flavon e (8), 5,7-dihydroxy-3'-(3-hydroxy-methylbutyl)-3,6,4'-trimethoxyflavone (9), 5,7-dihydroxy-3'-(4 `'-acetoxy-3''-methylbuty1)-3,6,4'-trimethoxy flavone (10), aromadendrin, (2S,3S) 3,4',5,7-tetrahydroxyflavanone (11), and pinocembrin (12), together with monohydrated crystal (1A) of 1 and anhydrous crystal (3A) of 3 - isolated from Dodonaea viscosa - were studied. The results are given as 50% inhibition concentrations (IC50). Their structure-activity relationships are discussed for both activities. Flavonoids 3 and 10 showed higher antioxidant activity in all tests. 3 Also showed moderate acetylcholinesterase (IC50: 182.97 +/- 1.25 mu M) and significant butyrylcholinesterase (IC50: 47.07 +/- 0.54 mu M) inhibitory activities. Compounds 2 (IC50: 55.78 +/- 1.01 mu M) and 3A (IC50: 58.72 +/- 1.02 mu M) were also moderate anticholinesterase agents against butyrylcholinesterase enzyme. Monohydrate crystal (1A) showed better antioxidant and anticholinesterase activities than its amorphous form (1). In contrast, the amorphous 3 exhibited better activity than the anhydrous crystal (3A). In hydrous crystal, the water molecule might be responsible for better activity. These natural flavonoids can be used as pharmaceuticals and/or preservatives in respective industries. (C) 2015 Elsevier B.V. All rights reserved. Elsevier 2015 Article PeerReviewed Muhammad, A. and Tel-Cayan, G. and Ozturk, M. and Nadeem, S. and Duru, M.E. and Anis, I. and Ng, S.W. and Shah, M.R. (2015) Biologically active flavonoids from Dodonaea viscosa and their structure-activity relationships. Industrial Crops and Products, 78. pp. 66-72. ISSN 0926-6690, DOI: 10.1016/j.indcrop.2015.10.011 |
spellingShingle | S Agriculture (General) Muhammad, A. Tel-Cayan, G. Ozturk, M. Nadeem, S. Duru, M.E. Anis, I. Ng, S.W. Shah, M.R. Biologically active flavonoids from Dodonaea viscosa and their structure-activity relationships |
title | Biologically active flavonoids from Dodonaea viscosa and their structure-activity relationships |
title_full | Biologically active flavonoids from Dodonaea viscosa and their structure-activity relationships |
title_fullStr | Biologically active flavonoids from Dodonaea viscosa and their structure-activity relationships |
title_full_unstemmed | Biologically active flavonoids from Dodonaea viscosa and their structure-activity relationships |
title_short | Biologically active flavonoids from Dodonaea viscosa and their structure-activity relationships |
title_sort | biologically active flavonoids from dodonaea viscosa and their structure activity relationships |
topic | S Agriculture (General) |
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