The influence of glycerol on the binding of methotrexate to Mycobacterium tuberculosis dihydrofolate reductase: a molecular modelling study
The enzyme, dihydrofolate reductase (DHFR), from Mycobacterium tuberculosis (mt-DHFR) is believed to be a potential drug target for the treatment of tuberculosis. The co-crystal structure of mt-DHFR bound with glycerol (GOL), NAPDH and methotrexate (MTX) reveals a GOL binding site on the enzyme. Thi...
Main Authors: | Hong, W., Chang, Z., Wang, Y., Sun, T., Pu, J., Paterson, I.C., Wang, H. |
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Format: | Article |
Published: |
2015
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Subjects: |
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