A preliminary screening of potentially antimalarial plants against Plasmodium falciparum in vitro
Plasmodium is a blood protozoan parasite that is responsible for malaria. To date, Plasmodium falciparum has shown multi-drug resistance, particularly in Thailand, Myanmar and Malaysia. The aim of the study is to screen the plant extracts that can effectively inhibit P. falciparum 3D7, a common lab...
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| Format: | Article |
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2015
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| _version_ | 1825720802045067264 |
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| author | Khaw, L.T. Leerach, N. Yap, N.J. Jaturas, N. Mahboob, T. Tan, T.C. Dungca, J.Z. LosBanos, Z.D. Sitthisak, S. Chow, S.C. Lim, Y.A.L. Sawangjaroen, N. Wiart, C. Nissapatorn, V. |
| author_facet | Khaw, L.T. Leerach, N. Yap, N.J. Jaturas, N. Mahboob, T. Tan, T.C. Dungca, J.Z. LosBanos, Z.D. Sitthisak, S. Chow, S.C. Lim, Y.A.L. Sawangjaroen, N. Wiart, C. Nissapatorn, V. |
| author_sort | Khaw, L.T. |
| collection | UM |
| description | Plasmodium is a blood protozoan parasite that is responsible for malaria. To date, Plasmodium falciparum has shown multi-drug resistance, particularly in Thailand, Myanmar and Malaysia. The aim of the study is to screen the plant extracts that can effectively inhibit P. falciparum 3D7, a common lab strain malaria parasite. Nine plants were collected and processed through maceration using hexane, chloroform and ethanol, resulting in 24 crude plant extracts. Of these, extracts from Artabotrys crassifolius, Pericampylus glacus and Leuconotis eugeniifolia showed promising antiplasmodial activities at IC50 of 15.32 to 39.75 mu g/mL in a modified schizont maturation assay. Further studies are warranted to explore its efficacies and lead compounds of these three plant extracts for the development of antiplasmodial drugs. |
| first_indexed | 2024-03-06T05:40:41Z |
| format | Article |
| id | um.eprints-16276 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:40:41Z |
| publishDate | 2015 |
| record_format | dspace |
| spelling | um.eprints-162762019-09-27T08:59:19Z http://eprints.um.edu.my/16276/ A preliminary screening of potentially antimalarial plants against Plasmodium falciparum in vitro Khaw, L.T. Leerach, N. Yap, N.J. Jaturas, N. Mahboob, T. Tan, T.C. Dungca, J.Z. LosBanos, Z.D. Sitthisak, S. Chow, S.C. Lim, Y.A.L. Sawangjaroen, N. Wiart, C. Nissapatorn, V. R Medicine (General) Plasmodium is a blood protozoan parasite that is responsible for malaria. To date, Plasmodium falciparum has shown multi-drug resistance, particularly in Thailand, Myanmar and Malaysia. The aim of the study is to screen the plant extracts that can effectively inhibit P. falciparum 3D7, a common lab strain malaria parasite. Nine plants were collected and processed through maceration using hexane, chloroform and ethanol, resulting in 24 crude plant extracts. Of these, extracts from Artabotrys crassifolius, Pericampylus glacus and Leuconotis eugeniifolia showed promising antiplasmodial activities at IC50 of 15.32 to 39.75 mu g/mL in a modified schizont maturation assay. Further studies are warranted to explore its efficacies and lead compounds of these three plant extracts for the development of antiplasmodial drugs. 2015 Article PeerReviewed Khaw, L.T. and Leerach, N. and Yap, N.J. and Jaturas, N. and Mahboob, T. and Tan, T.C. and Dungca, J.Z. and LosBanos, Z.D. and Sitthisak, S. and Chow, S.C. and Lim, Y.A.L. and Sawangjaroen, N. and Wiart, C. and Nissapatorn, V. (2015) A preliminary screening of potentially antimalarial plants against Plasmodium falciparum in vitro. Tropical Biomedicine, 32 (4). pp. 676-683. ISSN 0127-5720, |
| spellingShingle | R Medicine (General) Khaw, L.T. Leerach, N. Yap, N.J. Jaturas, N. Mahboob, T. Tan, T.C. Dungca, J.Z. LosBanos, Z.D. Sitthisak, S. Chow, S.C. Lim, Y.A.L. Sawangjaroen, N. Wiart, C. Nissapatorn, V. A preliminary screening of potentially antimalarial plants against Plasmodium falciparum in vitro |
| title | A preliminary screening of potentially antimalarial plants against Plasmodium falciparum in vitro |
| title_full | A preliminary screening of potentially antimalarial plants against Plasmodium falciparum in vitro |
| title_fullStr | A preliminary screening of potentially antimalarial plants against Plasmodium falciparum in vitro |
| title_full_unstemmed | A preliminary screening of potentially antimalarial plants against Plasmodium falciparum in vitro |
| title_short | A preliminary screening of potentially antimalarial plants against Plasmodium falciparum in vitro |
| title_sort | preliminary screening of potentially antimalarial plants against plasmodium falciparum in vitro |
| topic | R Medicine (General) |
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