Potent PPAR gamma Ligands from Swietenia macrophylla Are Capable of Stimulating Glucose Uptake in Muscle Cells
Numerous documented ethnopharmacological properties have been associated with Swietenia macrophylla (Meliaceae), with its seed extract reported to display anti-hypoglycemic activities in diabetic rats. In the present study, three compounds isolated from the seeds of S. macrophylla were tested on a m...
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| Format: | Article |
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2015
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| author | Lau, W.K. Goh, B.H. Kadir, H.A. Shu-Chien, A.C. Muhammad, T.S.T. |
| author_facet | Lau, W.K. Goh, B.H. Kadir, H.A. Shu-Chien, A.C. Muhammad, T.S.T. |
| author_sort | Lau, W.K. |
| collection | UM |
| description | Numerous documented ethnopharmacological properties have been associated with Swietenia macrophylla (Meliaceae), with its seed extract reported to display anti-hypoglycemic activities in diabetic rats. In the present study, three compounds isolated from the seeds of S. macrophylla were tested on a modified ELISA binding assay and showed to possess PPAR ligand activity. They were corresponded to PPAR-mediated cellular response, stimulated adipocyte differentiation but produced lower amount of fat droplets compared to a conventional anti-diabetic agent, rosiglitazone. The up-regulation of adipocytes was followed by increased adipocyte-related gene expressions such as adiponectin, adipsin, and PPAR. The S. macrophylla compounds also promoted cellular glucose uptake via the translocation of GLUT4 glucose transporter. |
| first_indexed | 2024-03-06T05:40:56Z |
| format | Article |
| id | um.eprints-16383 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:40:56Z |
| publishDate | 2015 |
| record_format | dspace |
| spelling | um.eprints-163832016-09-08T02:42:06Z http://eprints.um.edu.my/16383/ Potent PPAR gamma Ligands from Swietenia macrophylla Are Capable of Stimulating Glucose Uptake in Muscle Cells Lau, W.K. Goh, B.H. Kadir, H.A. Shu-Chien, A.C. Muhammad, T.S.T. Q Science (General) QD Chemistry Numerous documented ethnopharmacological properties have been associated with Swietenia macrophylla (Meliaceae), with its seed extract reported to display anti-hypoglycemic activities in diabetic rats. In the present study, three compounds isolated from the seeds of S. macrophylla were tested on a modified ELISA binding assay and showed to possess PPAR ligand activity. They were corresponded to PPAR-mediated cellular response, stimulated adipocyte differentiation but produced lower amount of fat droplets compared to a conventional anti-diabetic agent, rosiglitazone. The up-regulation of adipocytes was followed by increased adipocyte-related gene expressions such as adiponectin, adipsin, and PPAR. The S. macrophylla compounds also promoted cellular glucose uptake via the translocation of GLUT4 glucose transporter. 2015 Article PeerReviewed Lau, W.K. and Goh, B.H. and Kadir, H.A. and Shu-Chien, A.C. and Muhammad, T.S.T. (2015) Potent PPAR gamma Ligands from Swietenia macrophylla Are Capable of Stimulating Glucose Uptake in Muscle Cells. Molecules, 20 (12). pp. 22301-22314. ISSN 1420-3049, DOI: 10.3390/molecules201219847 |
| spellingShingle | Q Science (General) QD Chemistry Lau, W.K. Goh, B.H. Kadir, H.A. Shu-Chien, A.C. Muhammad, T.S.T. Potent PPAR gamma Ligands from Swietenia macrophylla Are Capable of Stimulating Glucose Uptake in Muscle Cells |
| title | Potent PPAR gamma Ligands from Swietenia macrophylla Are Capable of Stimulating Glucose Uptake in Muscle Cells |
| title_full | Potent PPAR gamma Ligands from Swietenia macrophylla Are Capable of Stimulating Glucose Uptake in Muscle Cells |
| title_fullStr | Potent PPAR gamma Ligands from Swietenia macrophylla Are Capable of Stimulating Glucose Uptake in Muscle Cells |
| title_full_unstemmed | Potent PPAR gamma Ligands from Swietenia macrophylla Are Capable of Stimulating Glucose Uptake in Muscle Cells |
| title_short | Potent PPAR gamma Ligands from Swietenia macrophylla Are Capable of Stimulating Glucose Uptake in Muscle Cells |
| title_sort | potent ppar gamma ligands from swietenia macrophylla are capable of stimulating glucose uptake in muscle cells |
| topic | Q Science (General) QD Chemistry |
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