Cryptic natural autoantibodies and co-potentiators
Natural autoantibodies are normal components of the humoral arm of the immune system found in clinically healthy individuals. There are two subpopulations of natural antibodies, including an overt group of antibodies that are readily detected in unfractionated normal human sera. The other natural an...
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| Format: | Article |
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Elsevier
2008
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| author | Cheng, Hwee Ming Chamley, Lawrence |
| author_facet | Cheng, Hwee Ming Chamley, Lawrence |
| author_sort | Cheng, Hwee Ming |
| collection | UM |
| description | Natural autoantibodies are normal components of the humoral arm of the immune system found in clinically healthy individuals. There are two subpopulations of natural antibodies, including an overt group of antibodies that are readily detected in unfractionated normal human sera. The other natural antibody subgroup is revealed by physico or biochemical treatment of normal human sera in vitro. Unmasking of this latter cryptic natural autoantibodies (cNA) may occur in vivo by local factors in the tissue environment of disease states. The masking cryptic factors may be immunoglobulin (Ig) or non-Ig in nature. These factors may either be co-inhibitors or co-enhancers of cNA. In the heat-potentiated binding of natural anti-phospholipid antibodies, apolipoprotein H (beta 2-glycoprotein I) appears to act as a co-enhancer. The immuno-relationship between the in vitro and in vivo cNA phenomenon remains to be elucidated. |
| first_indexed | 2024-03-06T05:06:22Z |
| format | Article |
| id | um.eprints-1658 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:06:22Z |
| publishDate | 2008 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | um.eprints-16582018-10-26T04:52:20Z http://eprints.um.edu.my/1658/ Cryptic natural autoantibodies and co-potentiators Cheng, Hwee Ming Chamley, Lawrence R Medicine Natural autoantibodies are normal components of the humoral arm of the immune system found in clinically healthy individuals. There are two subpopulations of natural antibodies, including an overt group of antibodies that are readily detected in unfractionated normal human sera. The other natural antibody subgroup is revealed by physico or biochemical treatment of normal human sera in vitro. Unmasking of this latter cryptic natural autoantibodies (cNA) may occur in vivo by local factors in the tissue environment of disease states. The masking cryptic factors may be immunoglobulin (Ig) or non-Ig in nature. These factors may either be co-inhibitors or co-enhancers of cNA. In the heat-potentiated binding of natural anti-phospholipid antibodies, apolipoprotein H (beta 2-glycoprotein I) appears to act as a co-enhancer. The immuno-relationship between the in vitro and in vivo cNA phenomenon remains to be elucidated. Elsevier 2008-06 Article PeerReviewed Cheng, Hwee Ming and Chamley, Lawrence (2008) Cryptic natural autoantibodies and co-potentiators. Autoimmunity Reviews, 7 (6). pp. 431-4. ISSN 1568-9972, DOI https://doi.org/10.1016/j.autrev.2008.03.011 <https://doi.org/10.1016/j.autrev.2008.03.011>. https://doi.org/10.1016/j.autrev.2008.03.011 doi:10.1016/j.autrev.2008.03.011 |
| spellingShingle | R Medicine Cheng, Hwee Ming Chamley, Lawrence Cryptic natural autoantibodies and co-potentiators |
| title | Cryptic natural autoantibodies and co-potentiators |
| title_full | Cryptic natural autoantibodies and co-potentiators |
| title_fullStr | Cryptic natural autoantibodies and co-potentiators |
| title_full_unstemmed | Cryptic natural autoantibodies and co-potentiators |
| title_short | Cryptic natural autoantibodies and co-potentiators |
| title_sort | cryptic natural autoantibodies and co potentiators |
| topic | R Medicine |
| work_keys_str_mv | AT chenghweeming crypticnaturalautoantibodiesandcopotentiators AT chamleylawrence crypticnaturalautoantibodiesandcopotentiators |