Anti-Inflammatory Activity of Calophyllum inophyllum Fruits Extracts

In the present work, we are reporting the isolation. characterisation and bioactvity of inophyllums, xanthones and other compounds found in the fruits of Callophyllum inophyllum. In-vitro assays demonstrated that the crude extract at concentration of 50 Pg/ml inhibited 77% and 88% cyclooxygenase and...

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Bibliographic Details
Main Author: Ilham, Zul
Format: Article
Language:English
Published: Elsevier 2014
Subjects:
Online Access:http://eprints.um.edu.my/16777/1/MZ2014-Calophyllum.pdf
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Summary:In the present work, we are reporting the isolation. characterisation and bioactvity of inophyllums, xanthones and other compounds found in the fruits of Callophyllum inophyllum. In-vitro assays demonstrated that the crude extract at concentration of 50 Pg/ml inhibited 77% and 88% cyclooxygenase and lipooxygenase activities, respectively, indicating its potential as antiinflamatory agent. Phytochemical studies was also conducted on the fruits. Inophyllum A, inophyllum C, inophyllum E, calophylloide, calophynic acid, 11,12-anhydroinophyllum A, 1,7-dihydroxy-6-methoxyxanthone, potocatechuic acid, gallic acid, n-nonacosane, E-sitosterol and sitosterol-3-O-E-D-glucopyranoside were isolated and idetified. On the HPLC chromatogram, at least 18 compounds can be detected.