Evaluation of MicroRNAs Regulating Anoikis Pathways and Its Therapeutic Potential
Dysregulation of microRNAs (miRNAs) has been implicated in almost every known survival mechanisms utilized by cancer cells. One of such mechanisms, anoikis resistance, plays a pivotal role in enabling metastasis by allowing cancer cells to circumvent cell death induced by lack of attachment. Underst...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2015
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| Online Access: | http://eprints.um.edu.my/17521/1/MalagobadanS_%282015%29.pdf |
| _version_ | 1825720939319394304 |
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| author | Malagobadan, S. Nagoor, N.H. |
| author_facet | Malagobadan, S. Nagoor, N.H. |
| author_sort | Malagobadan, S. |
| collection | UM |
| description | Dysregulation of microRNAs (miRNAs) has been implicated in almost every known survival mechanisms utilized by cancer cells. One of such mechanisms, anoikis resistance, plays a pivotal role in enabling metastasis by allowing cancer cells to circumvent cell death induced by lack of attachment. Understanding how miRNAs regulate the various anoikis pathways has become the research question of increasing number of studies published in the past years. Through these studies, a growing list of miRNAs has been identified to be important players in promoting either anoikis or resistance to anoikis. In this review, we will be focusing on these miRNAs and how the findings from those studies can contribute to novel therapeutic strategies against cancer progression. We will be examining miRNAs that have been found to promote anoikis sensitivity in numerous cancer types followed by miRNAs that inhibit anoikis. In addition, we will also be taking a look at major signaling pathways involved in the action of the each of these miRNAs to gain a better understanding on how miRNAs regulate anoikis. |
| first_indexed | 2024-03-06T05:42:45Z |
| format | Article |
| id | um.eprints-17521 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:42:45Z |
| publishDate | 2015 |
| publisher | Hindawi Publishing Corporation |
| record_format | dspace |
| spelling | um.eprints-175212017-07-17T03:48:04Z http://eprints.um.edu.my/17521/ Evaluation of MicroRNAs Regulating Anoikis Pathways and Its Therapeutic Potential Malagobadan, S. Nagoor, N.H. QH301 Biology Dysregulation of microRNAs (miRNAs) has been implicated in almost every known survival mechanisms utilized by cancer cells. One of such mechanisms, anoikis resistance, plays a pivotal role in enabling metastasis by allowing cancer cells to circumvent cell death induced by lack of attachment. Understanding how miRNAs regulate the various anoikis pathways has become the research question of increasing number of studies published in the past years. Through these studies, a growing list of miRNAs has been identified to be important players in promoting either anoikis or resistance to anoikis. In this review, we will be focusing on these miRNAs and how the findings from those studies can contribute to novel therapeutic strategies against cancer progression. We will be examining miRNAs that have been found to promote anoikis sensitivity in numerous cancer types followed by miRNAs that inhibit anoikis. In addition, we will also be taking a look at major signaling pathways involved in the action of the each of these miRNAs to gain a better understanding on how miRNAs regulate anoikis. Hindawi Publishing Corporation 2015 Article PeerReviewed application/pdf en http://eprints.um.edu.my/17521/1/MalagobadanS_%282015%29.pdf Malagobadan, S. and Nagoor, N.H. (2015) Evaluation of MicroRNAs Regulating Anoikis Pathways and Its Therapeutic Potential. BioMed Research International, 2015. pp. 1-10. ISSN 2314-6133, DOI https://doi.org/10.1155/2015/716816 <https://doi.org/10.1155/2015/716816>. http://dx.doi.org/10.1155/2015/716816 doi:10.1155/2015/716816 |
| spellingShingle | QH301 Biology Malagobadan, S. Nagoor, N.H. Evaluation of MicroRNAs Regulating Anoikis Pathways and Its Therapeutic Potential |
| title | Evaluation of MicroRNAs Regulating Anoikis Pathways and Its Therapeutic Potential |
| title_full | Evaluation of MicroRNAs Regulating Anoikis Pathways and Its Therapeutic Potential |
| title_fullStr | Evaluation of MicroRNAs Regulating Anoikis Pathways and Its Therapeutic Potential |
| title_full_unstemmed | Evaluation of MicroRNAs Regulating Anoikis Pathways and Its Therapeutic Potential |
| title_short | Evaluation of MicroRNAs Regulating Anoikis Pathways and Its Therapeutic Potential |
| title_sort | evaluation of micrornas regulating anoikis pathways and its therapeutic potential |
| topic | QH301 Biology |
| url | http://eprints.um.edu.my/17521/1/MalagobadanS_%282015%29.pdf |
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