Synthesis, characterization, properties of N-succinyl chitosan-g-poly (methacrylic acid) hydrogels and in vitro release of theophylline
Although there was great interest in the biocompatible and stimuli responsive polymeric materials in oral drug delivery systems in recent years. The stimuli sensitive and swellable hydrogels have got striking attention as promising materials for site specific controlled drug delivery. In the present...
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Elsevier
2016
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| author | Bashir, S. Teo, Y.Y. Ramesh, S. Ramesh, K. |
| author_facet | Bashir, S. Teo, Y.Y. Ramesh, S. Ramesh, K. |
| author_sort | Bashir, S. |
| collection | UM |
| description | Although there was great interest in the biocompatible and stimuli responsive polymeric materials in oral drug delivery systems in recent years. The stimuli sensitive and swellable hydrogels have got striking attention as promising materials for site specific controlled drug delivery. In the present study, unique biodegradable, biocompatible, swellable, and pH responsive N-succinyl chitosan-g- Poly (methacrylic acid) hydrogels were prepared through free radical mechanism for oral administration of theophylline. In this method, ammonium persulfate (APS) and N, N′-methylenebisacrylamide (MBA) were used as initiator and crosslinking agent, respectively. The physical properties characterization was performed by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), differential scanning calorimetry (DSC), field emission scanning electron microscope (FESEM), and rheometer. The results clearly confirmed the successful formation of N-succinyl chitosan-g- Poly (methacrylic acid) gel. In vitro degradation of hydrogels was found dependent on the ratio of monomers to crosslinking concentration. The effect of concentration of monomers, initiator, and crosslinking agent, pH and ionic strength of salts on swelling behavior was investigated. The results revealed the strong influence of these parameters, on swelling properties. Hydrogel prepared with high concentration of initiator and low crosslinking agent showed maximum swelling. The swelling showed good fitting to second order rate equation and the swelling kinetics data demonstrated the swelling behavior followed non-Fickian anomalous transport mechanism. Furthermore, theophylline loading and encapsulation efficiency (EE %) were found to be 14.5-23.5% and 58-94%, respectively. However, the in vitro release profile of theophylline was found dependent on pH, concentration of monomers, initiator, and crosslinking agent. The maximum release was found to be 90% in simulated intestinal fluid (SIF). The drug release data showed good fitting to Ritger-Peppas model. Moreover, the chemical activity of theophylline was also investigated and found that the drug maintained its chemical activity after in vitro release. |
| first_indexed | 2024-03-06T05:45:32Z |
| format | Article |
| id | um.eprints-18479 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:45:32Z |
| publishDate | 2016 |
| publisher | Elsevier |
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| spelling | um.eprints-184792017-12-07T03:31:05Z http://eprints.um.edu.my/18479/ Synthesis, characterization, properties of N-succinyl chitosan-g-poly (methacrylic acid) hydrogels and in vitro release of theophylline Bashir, S. Teo, Y.Y. Ramesh, S. Ramesh, K. Q Science (General) QC Physics QD Chemistry Although there was great interest in the biocompatible and stimuli responsive polymeric materials in oral drug delivery systems in recent years. The stimuli sensitive and swellable hydrogels have got striking attention as promising materials for site specific controlled drug delivery. In the present study, unique biodegradable, biocompatible, swellable, and pH responsive N-succinyl chitosan-g- Poly (methacrylic acid) hydrogels were prepared through free radical mechanism for oral administration of theophylline. In this method, ammonium persulfate (APS) and N, N′-methylenebisacrylamide (MBA) were used as initiator and crosslinking agent, respectively. The physical properties characterization was performed by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), differential scanning calorimetry (DSC), field emission scanning electron microscope (FESEM), and rheometer. The results clearly confirmed the successful formation of N-succinyl chitosan-g- Poly (methacrylic acid) gel. In vitro degradation of hydrogels was found dependent on the ratio of monomers to crosslinking concentration. The effect of concentration of monomers, initiator, and crosslinking agent, pH and ionic strength of salts on swelling behavior was investigated. The results revealed the strong influence of these parameters, on swelling properties. Hydrogel prepared with high concentration of initiator and low crosslinking agent showed maximum swelling. The swelling showed good fitting to second order rate equation and the swelling kinetics data demonstrated the swelling behavior followed non-Fickian anomalous transport mechanism. Furthermore, theophylline loading and encapsulation efficiency (EE %) were found to be 14.5-23.5% and 58-94%, respectively. However, the in vitro release profile of theophylline was found dependent on pH, concentration of monomers, initiator, and crosslinking agent. The maximum release was found to be 90% in simulated intestinal fluid (SIF). The drug release data showed good fitting to Ritger-Peppas model. Moreover, the chemical activity of theophylline was also investigated and found that the drug maintained its chemical activity after in vitro release. Elsevier 2016 Article PeerReviewed Bashir, S. and Teo, Y.Y. and Ramesh, S. and Ramesh, K. (2016) Synthesis, characterization, properties of N-succinyl chitosan-g-poly (methacrylic acid) hydrogels and in vitro release of theophylline. Polymer, 92. pp. 36-49. ISSN 0032-3861, DOI https://doi.org/10.1016/j.polymer.2016.03.045 <https://doi.org/10.1016/j.polymer.2016.03.045>. https://doi.org/10.1016/j.polymer.2016.03.045 doi:10.1016/j.polymer.2016.03.045 |
| spellingShingle | Q Science (General) QC Physics QD Chemistry Bashir, S. Teo, Y.Y. Ramesh, S. Ramesh, K. Synthesis, characterization, properties of N-succinyl chitosan-g-poly (methacrylic acid) hydrogels and in vitro release of theophylline |
| title | Synthesis, characterization, properties of N-succinyl chitosan-g-poly (methacrylic acid) hydrogels and in vitro release of theophylline |
| title_full | Synthesis, characterization, properties of N-succinyl chitosan-g-poly (methacrylic acid) hydrogels and in vitro release of theophylline |
| title_fullStr | Synthesis, characterization, properties of N-succinyl chitosan-g-poly (methacrylic acid) hydrogels and in vitro release of theophylline |
| title_full_unstemmed | Synthesis, characterization, properties of N-succinyl chitosan-g-poly (methacrylic acid) hydrogels and in vitro release of theophylline |
| title_short | Synthesis, characterization, properties of N-succinyl chitosan-g-poly (methacrylic acid) hydrogels and in vitro release of theophylline |
| title_sort | synthesis characterization properties of n succinyl chitosan g poly methacrylic acid hydrogels and in vitro release of theophylline |
| topic | Q Science (General) QC Physics QD Chemistry |
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