Phylogeographic Evidence for 2 Genetically Distinct ZoonoticPlasmodium knowlesiParasites, Malaysia
Infections of humans with the zoonotic simian malaria parasite Plasmodium knowlesi occur throughout Southeast Asia, although most cases have occurred in Malaysia, where P. knowlesi is now the dominant malaria species. This apparently skewed distribution prompted an investigation of the phylogeograph...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Published: |
Centers for Disease Control and Prevention
2016
|
| Subjects: |
| _version_ | 1825721164202246144 |
|---|---|
| author | Yusof, R. Ahmed, M.A. Jelip, J. Ngian, H.U. Mustakim, S. Hussin, H.M. Fong, M.Y. Mahmud, R. Sitam, F.A.T. Japning, J.R.R. Snounou, G. Escalante, A.A. Lau, Y.L. |
| author_facet | Yusof, R. Ahmed, M.A. Jelip, J. Ngian, H.U. Mustakim, S. Hussin, H.M. Fong, M.Y. Mahmud, R. Sitam, F.A.T. Japning, J.R.R. Snounou, G. Escalante, A.A. Lau, Y.L. |
| author_sort | Yusof, R. |
| collection | UM |
| description | Infections of humans with the zoonotic simian malaria parasite Plasmodium knowlesi occur throughout Southeast Asia, although most cases have occurred in Malaysia, where P. knowlesi is now the dominant malaria species. This apparently skewed distribution prompted an investigation of the phylogeography of this parasite in 2 geographically separated regions of Malaysia, Peninsular Malaysia and Malaysian Borneo. We investigated samples collected from humans and macaques in these regions. Haplotype network analyses of sequences from 2 P. knowlesi genes, type A small subunit ribosomal 18S RNA and cytochrome c oxidase subunit I, showed 2 genetically distinct divergent clusters, 1 from each of the 2 regions of Malaysia. We propose that these parasites represent 2 distinct P. knowlesi types that independently became zoonotic. These types would have evolved after the sea-level rise at the end of the last ice age, which separated Malaysian Borneo from Peninsular Malaysia. |
| first_indexed | 2024-03-06T05:46:12Z |
| format | Article |
| id | um.eprints-18739 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:46:12Z |
| publishDate | 2016 |
| publisher | Centers for Disease Control and Prevention |
| record_format | dspace |
| spelling | um.eprints-187392018-05-28T03:02:54Z http://eprints.um.edu.my/18739/ Phylogeographic Evidence for 2 Genetically Distinct ZoonoticPlasmodium knowlesiParasites, Malaysia Yusof, R. Ahmed, M.A. Jelip, J. Ngian, H.U. Mustakim, S. Hussin, H.M. Fong, M.Y. Mahmud, R. Sitam, F.A.T. Japning, J.R.R. Snounou, G. Escalante, A.A. Lau, Y.L. R Medicine Infections of humans with the zoonotic simian malaria parasite Plasmodium knowlesi occur throughout Southeast Asia, although most cases have occurred in Malaysia, where P. knowlesi is now the dominant malaria species. This apparently skewed distribution prompted an investigation of the phylogeography of this parasite in 2 geographically separated regions of Malaysia, Peninsular Malaysia and Malaysian Borneo. We investigated samples collected from humans and macaques in these regions. Haplotype network analyses of sequences from 2 P. knowlesi genes, type A small subunit ribosomal 18S RNA and cytochrome c oxidase subunit I, showed 2 genetically distinct divergent clusters, 1 from each of the 2 regions of Malaysia. We propose that these parasites represent 2 distinct P. knowlesi types that independently became zoonotic. These types would have evolved after the sea-level rise at the end of the last ice age, which separated Malaysian Borneo from Peninsular Malaysia. Centers for Disease Control and Prevention 2016 Article PeerReviewed Yusof, R. and Ahmed, M.A. and Jelip, J. and Ngian, H.U. and Mustakim, S. and Hussin, H.M. and Fong, M.Y. and Mahmud, R. and Sitam, F.A.T. and Japning, J.R.R. and Snounou, G. and Escalante, A.A. and Lau, Y.L. (2016) Phylogeographic Evidence for 2 Genetically Distinct ZoonoticPlasmodium knowlesiParasites, Malaysia. Emerging Infectious Diseases, 22 (8). pp. 1371-1380. ISSN 1080-6040, DOI https://doi.org/10.3201/eid2208.151885 <https://doi.org/10.3201/eid2208.151885>. http://dx.doi.org/10.3201/eid2208.151885 doi:10.3201/eid2208.151885 |
| spellingShingle | R Medicine Yusof, R. Ahmed, M.A. Jelip, J. Ngian, H.U. Mustakim, S. Hussin, H.M. Fong, M.Y. Mahmud, R. Sitam, F.A.T. Japning, J.R.R. Snounou, G. Escalante, A.A. Lau, Y.L. Phylogeographic Evidence for 2 Genetically Distinct ZoonoticPlasmodium knowlesiParasites, Malaysia |
| title | Phylogeographic Evidence for 2 Genetically Distinct ZoonoticPlasmodium knowlesiParasites, Malaysia |
| title_full | Phylogeographic Evidence for 2 Genetically Distinct ZoonoticPlasmodium knowlesiParasites, Malaysia |
| title_fullStr | Phylogeographic Evidence for 2 Genetically Distinct ZoonoticPlasmodium knowlesiParasites, Malaysia |
| title_full_unstemmed | Phylogeographic Evidence for 2 Genetically Distinct ZoonoticPlasmodium knowlesiParasites, Malaysia |
| title_short | Phylogeographic Evidence for 2 Genetically Distinct ZoonoticPlasmodium knowlesiParasites, Malaysia |
| title_sort | phylogeographic evidence for 2 genetically distinct zoonoticplasmodium knowlesiparasites malaysia |
| topic | R Medicine |
| work_keys_str_mv | AT yusofr phylogeographicevidencefor2geneticallydistinctzoonoticplasmodiumknowlesiparasitesmalaysia AT ahmedma phylogeographicevidencefor2geneticallydistinctzoonoticplasmodiumknowlesiparasitesmalaysia AT jelipj phylogeographicevidencefor2geneticallydistinctzoonoticplasmodiumknowlesiparasitesmalaysia AT ngianhu phylogeographicevidencefor2geneticallydistinctzoonoticplasmodiumknowlesiparasitesmalaysia AT mustakims phylogeographicevidencefor2geneticallydistinctzoonoticplasmodiumknowlesiparasitesmalaysia AT hussinhm phylogeographicevidencefor2geneticallydistinctzoonoticplasmodiumknowlesiparasitesmalaysia AT fongmy phylogeographicevidencefor2geneticallydistinctzoonoticplasmodiumknowlesiparasitesmalaysia AT mahmudr phylogeographicevidencefor2geneticallydistinctzoonoticplasmodiumknowlesiparasitesmalaysia AT sitamfat phylogeographicevidencefor2geneticallydistinctzoonoticplasmodiumknowlesiparasitesmalaysia AT japningjrr phylogeographicevidencefor2geneticallydistinctzoonoticplasmodiumknowlesiparasitesmalaysia AT snounoug phylogeographicevidencefor2geneticallydistinctzoonoticplasmodiumknowlesiparasitesmalaysia AT escalanteaa phylogeographicevidencefor2geneticallydistinctzoonoticplasmodiumknowlesiparasitesmalaysia AT lauyl phylogeographicevidencefor2geneticallydistinctzoonoticplasmodiumknowlesiparasitesmalaysia |