Synthesis and gastroprotective activities of some zinc (II) complexes derived from (E)-2-(1-(2-(piperazin-1-yl)ethylimino)ethyl)phenol and (E)-4-(1-(2-(piperazin-1-yl)ethylimino)ethyl)benzene-1,3-diol Schiff bases against aspirin induced ulceration
This study describes the protective effects of piperazine derived compounds against aspirin induced gastric injuries and evaluated the role of nitric oxide, inflammatory cytokines and serum level of aspartate aminotransaminases (AST), alanine aminotransaminases (ALT), high density lipoprotein (HDL)...
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| Format: | Article |
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Elsevier
2017
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| _version_ | 1825721221162991616 |
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| author | Salga, M.S. Ali, Hapipah Mohd Abdulla, Mahmood Ameen Abdelwahab, S.I. ElhassanTaha, M.M. Yagoub, U. |
| author_facet | Salga, M.S. Ali, Hapipah Mohd Abdulla, Mahmood Ameen Abdelwahab, S.I. ElhassanTaha, M.M. Yagoub, U. |
| author_sort | Salga, M.S. |
| collection | UM |
| description | This study describes the protective effects of piperazine derived compounds against aspirin induced gastric injuries and evaluated the role of nitric oxide, inflammatory cytokines and serum level of aspartate aminotransaminases (AST), alanine aminotransaminases (ALT), high density lipoprotein (HDL) and malondialdehyde (MDA). The oral administration of the compounds at doses 30 and 60 mg/kg protected the gastric against the nectrotizing effects of aspirin. The level of nitric oxide (NO) was elevated in the group pretreated with the compounds. The results also showed that pre-treatment with piperazine compounds has led to the decrease in the amount of MDA and increased the activity of AST, ALT and HDL. In conclusion, pre-treatment with piperazine derived compounds; (E)-2-(1-(2-(piperazin-1-yl)ethylimino)ethyl)phenol (2HP), (E)-4-(1-(2-(piperazin-1-yl)ethylimino)ethyl) benzene-1,3-diol (DHP) and their zinc complexes has provided a significant protection to the gastric from damaging effects of aspirin. |
| first_indexed | 2024-03-06T05:47:05Z |
| format | Article |
| id | um.eprints-19036 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:47:05Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | um.eprints-190362019-01-30T01:44:33Z http://eprints.um.edu.my/19036/ Synthesis and gastroprotective activities of some zinc (II) complexes derived from (E)-2-(1-(2-(piperazin-1-yl)ethylimino)ethyl)phenol and (E)-4-(1-(2-(piperazin-1-yl)ethylimino)ethyl)benzene-1,3-diol Schiff bases against aspirin induced ulceration Salga, M.S. Ali, Hapipah Mohd Abdulla, Mahmood Ameen Abdelwahab, S.I. ElhassanTaha, M.M. Yagoub, U. QD Chemistry R Medicine This study describes the protective effects of piperazine derived compounds against aspirin induced gastric injuries and evaluated the role of nitric oxide, inflammatory cytokines and serum level of aspartate aminotransaminases (AST), alanine aminotransaminases (ALT), high density lipoprotein (HDL) and malondialdehyde (MDA). The oral administration of the compounds at doses 30 and 60 mg/kg protected the gastric against the nectrotizing effects of aspirin. The level of nitric oxide (NO) was elevated in the group pretreated with the compounds. The results also showed that pre-treatment with piperazine compounds has led to the decrease in the amount of MDA and increased the activity of AST, ALT and HDL. In conclusion, pre-treatment with piperazine derived compounds; (E)-2-(1-(2-(piperazin-1-yl)ethylimino)ethyl)phenol (2HP), (E)-4-(1-(2-(piperazin-1-yl)ethylimino)ethyl) benzene-1,3-diol (DHP) and their zinc complexes has provided a significant protection to the gastric from damaging effects of aspirin. Elsevier 2017 Article PeerReviewed Salga, M.S. and Ali, Hapipah Mohd and Abdulla, Mahmood Ameen and Abdelwahab, S.I. and ElhassanTaha, M.M. and Yagoub, U. (2017) Synthesis and gastroprotective activities of some zinc (II) complexes derived from (E)-2-(1-(2-(piperazin-1-yl)ethylimino)ethyl)phenol and (E)-4-(1-(2-(piperazin-1-yl)ethylimino)ethyl)benzene-1,3-diol Schiff bases against aspirin induced ulceration. Arabian Journal of Chemistry, 10. S1578-S1589. ISSN 1878-5352, DOI https://doi.org/10.1016/j.arabjc.2013.05.028 <https://doi.org/10.1016/j.arabjc.2013.05.028>. http://dx.doi.org/10.1016/j.arabjc.2013.05.028 doi:10.1016/j.arabjc.2013.05.028 |
| spellingShingle | QD Chemistry R Medicine Salga, M.S. Ali, Hapipah Mohd Abdulla, Mahmood Ameen Abdelwahab, S.I. ElhassanTaha, M.M. Yagoub, U. Synthesis and gastroprotective activities of some zinc (II) complexes derived from (E)-2-(1-(2-(piperazin-1-yl)ethylimino)ethyl)phenol and (E)-4-(1-(2-(piperazin-1-yl)ethylimino)ethyl)benzene-1,3-diol Schiff bases against aspirin induced ulceration |
| title | Synthesis and gastroprotective activities of some zinc (II) complexes derived from (E)-2-(1-(2-(piperazin-1-yl)ethylimino)ethyl)phenol and (E)-4-(1-(2-(piperazin-1-yl)ethylimino)ethyl)benzene-1,3-diol Schiff bases against aspirin induced ulceration |
| title_full | Synthesis and gastroprotective activities of some zinc (II) complexes derived from (E)-2-(1-(2-(piperazin-1-yl)ethylimino)ethyl)phenol and (E)-4-(1-(2-(piperazin-1-yl)ethylimino)ethyl)benzene-1,3-diol Schiff bases against aspirin induced ulceration |
| title_fullStr | Synthesis and gastroprotective activities of some zinc (II) complexes derived from (E)-2-(1-(2-(piperazin-1-yl)ethylimino)ethyl)phenol and (E)-4-(1-(2-(piperazin-1-yl)ethylimino)ethyl)benzene-1,3-diol Schiff bases against aspirin induced ulceration |
| title_full_unstemmed | Synthesis and gastroprotective activities of some zinc (II) complexes derived from (E)-2-(1-(2-(piperazin-1-yl)ethylimino)ethyl)phenol and (E)-4-(1-(2-(piperazin-1-yl)ethylimino)ethyl)benzene-1,3-diol Schiff bases against aspirin induced ulceration |
| title_short | Synthesis and gastroprotective activities of some zinc (II) complexes derived from (E)-2-(1-(2-(piperazin-1-yl)ethylimino)ethyl)phenol and (E)-4-(1-(2-(piperazin-1-yl)ethylimino)ethyl)benzene-1,3-diol Schiff bases against aspirin induced ulceration |
| title_sort | synthesis and gastroprotective activities of some zinc ii complexes derived from e 2 1 2 piperazin 1 yl ethylimino ethyl phenol and e 4 1 2 piperazin 1 yl ethylimino ethyl benzene 1 3 diol schiff bases against aspirin induced ulceration |
| topic | QD Chemistry R Medicine |
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