Microencapsulation of fish oil using supercritical antisolvent process
In order to improve the encapsulation process, a newly supercritical antisolvent process was developed to encapsulate fish oil using hydroxypropyl methyl cellulose as a polymer. Three factors, namely, temperature, pressure, and feed emulsion rate were optimized using response surface methodology. Th...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
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Elsevier
2017
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| _version_ | 1825721243190427648 |
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| author | Karim, F.T. Ghafoor, K. Ferdosh, S. Al-Juhaimi, F. Ali, M.E. Yunus, K. Hamed, M.H. Islam, A. Asif, M. Sarker, M.Z.I. |
| author_facet | Karim, F.T. Ghafoor, K. Ferdosh, S. Al-Juhaimi, F. Ali, M.E. Yunus, K. Hamed, M.H. Islam, A. Asif, M. Sarker, M.Z.I. |
| author_sort | Karim, F.T. |
| collection | UM |
| description | In order to improve the encapsulation process, a newly supercritical antisolvent process was developed to encapsulate fish oil using hydroxypropyl methyl cellulose as a polymer. Three factors, namely, temperature, pressure, and feed emulsion rate were optimized using response surface methodology. The suitability of the model for predicting the optimum response value was evaluated at the conditions of temperature at 60°C, pressure at 150 bar, and feed rate at 1.36 mL/min. At the optimum conditions, particle size of 58.35 μm was obtained. The surface morphology of the micronized fish oil was also evaluated using field emission scanning electron microscopy where it showed that particles formed spherical structures with no internal voids. Moreover, in vitro release of oil showed that there are significant differences of release percentage of oil between the formulations and the results proved that there was a significant decrease in the in vitro release of oil from the powder when the polymer concentration was high. |
| first_indexed | 2024-03-06T05:47:25Z |
| format | Article |
| id | um.eprints-19148 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:47:25Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | um.eprints-191482018-09-06T03:11:29Z http://eprints.um.edu.my/19148/ Microencapsulation of fish oil using supercritical antisolvent process Karim, F.T. Ghafoor, K. Ferdosh, S. Al-Juhaimi, F. Ali, M.E. Yunus, K. Hamed, M.H. Islam, A. Asif, M. Sarker, M.Z.I. Q Science (General) In order to improve the encapsulation process, a newly supercritical antisolvent process was developed to encapsulate fish oil using hydroxypropyl methyl cellulose as a polymer. Three factors, namely, temperature, pressure, and feed emulsion rate were optimized using response surface methodology. The suitability of the model for predicting the optimum response value was evaluated at the conditions of temperature at 60°C, pressure at 150 bar, and feed rate at 1.36 mL/min. At the optimum conditions, particle size of 58.35 μm was obtained. The surface morphology of the micronized fish oil was also evaluated using field emission scanning electron microscopy where it showed that particles formed spherical structures with no internal voids. Moreover, in vitro release of oil showed that there are significant differences of release percentage of oil between the formulations and the results proved that there was a significant decrease in the in vitro release of oil from the powder when the polymer concentration was high. Elsevier 2017 Article PeerReviewed Karim, F.T. and Ghafoor, K. and Ferdosh, S. and Al-Juhaimi, F. and Ali, M.E. and Yunus, K. and Hamed, M.H. and Islam, A. and Asif, M. and Sarker, M.Z.I. (2017) Microencapsulation of fish oil using supercritical antisolvent process. Journal of Food and Drug Analysis, 25 (3). pp. 654-666. ISSN 1021-9498, DOI https://doi.org/10.1016/j.jfda.2016.11.017 <https://doi.org/10.1016/j.jfda.2016.11.017>. http://dx.doi.org/10.1016/j.jfda.2016.11.017 doi:10.1016/j.jfda.2016.11.017 |
| spellingShingle | Q Science (General) Karim, F.T. Ghafoor, K. Ferdosh, S. Al-Juhaimi, F. Ali, M.E. Yunus, K. Hamed, M.H. Islam, A. Asif, M. Sarker, M.Z.I. Microencapsulation of fish oil using supercritical antisolvent process |
| title | Microencapsulation of fish oil using supercritical antisolvent process |
| title_full | Microencapsulation of fish oil using supercritical antisolvent process |
| title_fullStr | Microencapsulation of fish oil using supercritical antisolvent process |
| title_full_unstemmed | Microencapsulation of fish oil using supercritical antisolvent process |
| title_short | Microencapsulation of fish oil using supercritical antisolvent process |
| title_sort | microencapsulation of fish oil using supercritical antisolvent process |
| topic | Q Science (General) |
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