A validation study of the leeds dyspepsia questionnaire in a multi-ethnic asian population
Background Outcome measures for clinical trials in dyspepsia require an assessment of symptom response. There is a lack of validated instruments assessing dyspepsia symptoms in the Asian region. We aimed to translate and validate the Leeds Dyspepsia Questionnaire (LDQ) in a multi-ethnic Asian popula...
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| Format: | Article |
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Blackwell Scientific Publications
2011
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| author | Mahadeva, S. Chan, W.K. Mohazmi, M. Sujarita, R. Goh, K.L. |
| author_facet | Mahadeva, S. Chan, W.K. Mohazmi, M. Sujarita, R. Goh, K.L. |
| author_sort | Mahadeva, S. |
| collection | UM |
| description | Background Outcome measures for clinical trials in dyspepsia require an assessment of symptom response. There is a lack of validated instruments assessing dyspepsia symptoms in the Asian region. We aimed to translate and validate the Leeds Dyspepsia Questionnaire (LDQ) in a multi-ethnic Asian population. Methods A Malay and culturally adapted English version of the LDQ were developed according to established protocols. Psychometric evaluation was performed by assessing the validity, internal consistency, test-retest reliability and responsiveness of the instruments in both primary and secondary care patients. Results Between April and September 2010, both Malay (n = 166) and Malaysian English (n = 154) versions were assessed in primary and secondary care patients. Both language versions were found to be reliable (internal consistency was 0.80 and 0.74 (Cronbach's α) for Malay and English respectively; spearman's correlation coefficient for test-retest reliability was 0.98 for both versions), valid (area under receiver operating curve for accuracy of diagnosing dyspepsia was 0.71 and 0.77 for Malay and English versions respectively), discriminative (median LDQ score discriminated between primary and secondary care patients in Malay (11.0 vs 20.0, p < 0.0001) and English (10.0 vs 14.0, p = 0.001), and responsive (median LDQ score reduced after treatment in Malay (17.0 to 14.0, p = 0.08) and English (18.0 to 11.0, p = 0.008) to dyspepsia. Conclusion The Malaysian versions of the LDQ are valid, reliable and responsive instruments for assessing symptoms in a multi-ethnic Asian population with dyspepsia. |
| first_indexed | 2024-03-06T05:06:48Z |
| format | Article |
| id | um.eprints-1926 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:06:48Z |
| publishDate | 2011 |
| publisher | Blackwell Scientific Publications |
| record_format | dspace |
| spelling | um.eprints-19262013-12-11T06:53:38Z http://eprints.um.edu.my/1926/ A validation study of the leeds dyspepsia questionnaire in a multi-ethnic asian population Mahadeva, S. Chan, W.K. Mohazmi, M. Sujarita, R. Goh, K.L. R Medicine Background Outcome measures for clinical trials in dyspepsia require an assessment of symptom response. There is a lack of validated instruments assessing dyspepsia symptoms in the Asian region. We aimed to translate and validate the Leeds Dyspepsia Questionnaire (LDQ) in a multi-ethnic Asian population. Methods A Malay and culturally adapted English version of the LDQ were developed according to established protocols. Psychometric evaluation was performed by assessing the validity, internal consistency, test-retest reliability and responsiveness of the instruments in both primary and secondary care patients. Results Between April and September 2010, both Malay (n = 166) and Malaysian English (n = 154) versions were assessed in primary and secondary care patients. Both language versions were found to be reliable (internal consistency was 0.80 and 0.74 (Cronbach's α) for Malay and English respectively; spearman's correlation coefficient for test-retest reliability was 0.98 for both versions), valid (area under receiver operating curve for accuracy of diagnosing dyspepsia was 0.71 and 0.77 for Malay and English versions respectively), discriminative (median LDQ score discriminated between primary and secondary care patients in Malay (11.0 vs 20.0, p < 0.0001) and English (10.0 vs 14.0, p = 0.001), and responsive (median LDQ score reduced after treatment in Malay (17.0 to 14.0, p = 0.08) and English (18.0 to 11.0, p = 0.008) to dyspepsia. Conclusion The Malaysian versions of the LDQ are valid, reliable and responsive instruments for assessing symptoms in a multi-ethnic Asian population with dyspepsia. Blackwell Scientific Publications 2011 Article PeerReviewed Mahadeva, S. and Chan, W.K. and Mohazmi, M. and Sujarita, R. and Goh, K.L. (2011) A validation study of the leeds dyspepsia questionnaire in a multi-ethnic asian population. European Journal of Gastroenterology and Hepatology. ISSN 0815-9319, DOI 21649731. http://www.ncbi.nlm.nih.gov/pubmed/21649731 21649731 |
| spellingShingle | R Medicine Mahadeva, S. Chan, W.K. Mohazmi, M. Sujarita, R. Goh, K.L. A validation study of the leeds dyspepsia questionnaire in a multi-ethnic asian population |
| title | A validation study of the leeds dyspepsia questionnaire in a multi-ethnic asian population |
| title_full | A validation study of the leeds dyspepsia questionnaire in a multi-ethnic asian population |
| title_fullStr | A validation study of the leeds dyspepsia questionnaire in a multi-ethnic asian population |
| title_full_unstemmed | A validation study of the leeds dyspepsia questionnaire in a multi-ethnic asian population |
| title_short | A validation study of the leeds dyspepsia questionnaire in a multi-ethnic asian population |
| title_sort | validation study of the leeds dyspepsia questionnaire in a multi ethnic asian population |
| topic | R Medicine |
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