Genome-based Proteomic Analysis of Lignosus rhinocerotis (Cooke) Ryvarden Sclerotium
Lignosus rhinocerotis (Cooke) Ryvarden (Polyporales, Basidiomycota), also known as the tiger milk mushroom, has received much interest in recent years owing to its wide-range ethnobotanical uses and the recent success in its domestication. The sclerotium is the part with medicinal value. Using two-d...
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| Format: | Article |
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Ivyspring International Publisher
2015
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| author | Yap, H.Y.Y. Fung, S.Y. Ng, S.T. Tan, C.S. Tan, N.H. |
| author_facet | Yap, H.Y.Y. Fung, S.Y. Ng, S.T. Tan, C.S. Tan, N.H. |
| author_sort | Yap, H.Y.Y. |
| collection | UM |
| description | Lignosus rhinocerotis (Cooke) Ryvarden (Polyporales, Basidiomycota), also known as the tiger milk mushroom, has received much interest in recent years owing to its wide-range ethnobotanical uses and the recent success in its domestication. The sclerotium is the part with medicinal value. Using two-dimensional gel electrophoresis coupled with mass spectrometry analysis, a total of 16 non-redundant, major proteins were identified with high confidence level in L. rhinocerotis sclerotium based on its genome as custom mapping database. Some of these proteins, such as the putative lectins, immunomodulatory proteins, superoxide dismutase, and aegerolysin may have pharmaceutical potential; while others are involved in nutrient mobilization and the protective antioxidant mechanism in the sclerotium. The findings from this study provide a molecular basis for future research on potential pharmacologically active proteins of L. rhinocerotis. |
| first_indexed | 2024-03-06T05:48:11Z |
| format | Article |
| id | um.eprints-19403 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:48:11Z |
| publishDate | 2015 |
| publisher | Ivyspring International Publisher |
| record_format | dspace |
| spelling | um.eprints-194032018-09-25T05:24:39Z http://eprints.um.edu.my/19403/ Genome-based Proteomic Analysis of Lignosus rhinocerotis (Cooke) Ryvarden Sclerotium Yap, H.Y.Y. Fung, S.Y. Ng, S.T. Tan, C.S. Tan, N.H. R Medicine Lignosus rhinocerotis (Cooke) Ryvarden (Polyporales, Basidiomycota), also known as the tiger milk mushroom, has received much interest in recent years owing to its wide-range ethnobotanical uses and the recent success in its domestication. The sclerotium is the part with medicinal value. Using two-dimensional gel electrophoresis coupled with mass spectrometry analysis, a total of 16 non-redundant, major proteins were identified with high confidence level in L. rhinocerotis sclerotium based on its genome as custom mapping database. Some of these proteins, such as the putative lectins, immunomodulatory proteins, superoxide dismutase, and aegerolysin may have pharmaceutical potential; while others are involved in nutrient mobilization and the protective antioxidant mechanism in the sclerotium. The findings from this study provide a molecular basis for future research on potential pharmacologically active proteins of L. rhinocerotis. Ivyspring International Publisher 2015 Article PeerReviewed Yap, H.Y.Y. and Fung, S.Y. and Ng, S.T. and Tan, C.S. and Tan, N.H. (2015) Genome-based Proteomic Analysis of Lignosus rhinocerotis (Cooke) Ryvarden Sclerotium. International Journal of Medical Sciences, 12 (1). pp. 23-31. ISSN 1449-1907, DOI https://doi.org/10.7150/ijms.10019 <https://doi.org/10.7150/ijms.10019>. http://dx.doi.org/10.7150/ijms.10019 doi:10.7150/ijms.10019 |
| spellingShingle | R Medicine Yap, H.Y.Y. Fung, S.Y. Ng, S.T. Tan, C.S. Tan, N.H. Genome-based Proteomic Analysis of Lignosus rhinocerotis (Cooke) Ryvarden Sclerotium |
| title | Genome-based Proteomic Analysis of Lignosus rhinocerotis (Cooke) Ryvarden Sclerotium |
| title_full | Genome-based Proteomic Analysis of Lignosus rhinocerotis (Cooke) Ryvarden Sclerotium |
| title_fullStr | Genome-based Proteomic Analysis of Lignosus rhinocerotis (Cooke) Ryvarden Sclerotium |
| title_full_unstemmed | Genome-based Proteomic Analysis of Lignosus rhinocerotis (Cooke) Ryvarden Sclerotium |
| title_short | Genome-based Proteomic Analysis of Lignosus rhinocerotis (Cooke) Ryvarden Sclerotium |
| title_sort | genome based proteomic analysis of lignosus rhinocerotis cooke ryvarden sclerotium |
| topic | R Medicine |
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