Investigation on Secondary Structure Perturbations of Proteins Embedded in Solid Lipid Matrices as a Novel Indicator of their Biological Activity upon In Vitro Release

Investigation on Secondary Structure Perturbations of Proteins Embedded in Solid Lipid Matrices as a Novel Indicator of their Biological Activity upon In Vitro Release

Protein biologics are prone to conformational changes during formulation development. Limited methods are available for conformational analysis of proteins in solid state and in the presences of formulation excipients. The aim of this study was to investigate the secondary structures of proteins enc...

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Bibliographic Details
Main Authors:	Zeeshan, Farrukh, Tabbassum, Misbah, Jorgensen, Lene, Medlicott, Natalie J.
Format:	Article
Published:	2018
Subjects:	QD Chemistry RS Pharmacy and materia medica

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