Silver nanoparticles decorated polyaniline nanocomposite based electrochemical sensor for the determination of anticancer drug 5-fluorouracil
A highly efficient electrochemical sensor for the analysis of anticancer drug 5-fluorouracil (5-FU), is fabricated based on silver nanoparticles-polyaniline nanotube (AgNPs@PANINTs). AgNPs@PANINTs nanocomposite has been synthesized by a simple one-step method. Synthesized AgNPs@PANINTs nanocomposite...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Published: |
Elsevier
2018
|
| Subjects: |
| _version_ | 1796960837754159104 |
|---|---|
| author | Zahed, Fatemeh Modarres Hatamluyi, Behnaz Lorestani, Farnaz Es’haghi, Zarrin |
| author_facet | Zahed, Fatemeh Modarres Hatamluyi, Behnaz Lorestani, Farnaz Es’haghi, Zarrin |
| author_sort | Zahed, Fatemeh Modarres |
| collection | UM |
| description | A highly efficient electrochemical sensor for the analysis of anticancer drug 5-fluorouracil (5-FU), is fabricated based on silver nanoparticles-polyaniline nanotube (AgNPs@PANINTs). AgNPs@PANINTs nanocomposite has been synthesized by a simple one-step method. Synthesized AgNPs@PANINTs nanocomposite was studied by Fourier transform infrared spectrometry, Scanning Electron Microscopy and Energy Dispersive X-ray. The fabricated PANINTs@AgNPs PGE was applied to the electrochemical sensing of 5-FU. Cyclic voltammetry and differential pulse voltammetry experiments illustrated high electro activity for the AgNPs@PANINTs nanocomposite. The study was explored using the Taguchi experimental design method. Electrochemical measurements using differential pulse voltammetry showed a wide linear relationship between 5-FU concentration and peak height within the range 1.0–300.0 μM with a low detection limit (0.06 μM). Also, the fabricated sensor showed excellent selectivity in the presence of two anticancer drugs and a number of other interfering compounds. The as-prepared sensor showed to be a promising device for a simple, rapid, and direct analysis of 5-FU. |
| first_indexed | 2024-03-06T05:50:33Z |
| format | Article |
| id | um.eprints-20217 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:50:33Z |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | um.eprints-202172019-01-30T02:01:43Z http://eprints.um.edu.my/20217/ Silver nanoparticles decorated polyaniline nanocomposite based electrochemical sensor for the determination of anticancer drug 5-fluorouracil Zahed, Fatemeh Modarres Hatamluyi, Behnaz Lorestani, Farnaz Es’haghi, Zarrin Q Science (General) QD Chemistry A highly efficient electrochemical sensor for the analysis of anticancer drug 5-fluorouracil (5-FU), is fabricated based on silver nanoparticles-polyaniline nanotube (AgNPs@PANINTs). AgNPs@PANINTs nanocomposite has been synthesized by a simple one-step method. Synthesized AgNPs@PANINTs nanocomposite was studied by Fourier transform infrared spectrometry, Scanning Electron Microscopy and Energy Dispersive X-ray. The fabricated PANINTs@AgNPs PGE was applied to the electrochemical sensing of 5-FU. Cyclic voltammetry and differential pulse voltammetry experiments illustrated high electro activity for the AgNPs@PANINTs nanocomposite. The study was explored using the Taguchi experimental design method. Electrochemical measurements using differential pulse voltammetry showed a wide linear relationship between 5-FU concentration and peak height within the range 1.0–300.0 μM with a low detection limit (0.06 μM). Also, the fabricated sensor showed excellent selectivity in the presence of two anticancer drugs and a number of other interfering compounds. The as-prepared sensor showed to be a promising device for a simple, rapid, and direct analysis of 5-FU. Elsevier 2018 Article PeerReviewed Zahed, Fatemeh Modarres and Hatamluyi, Behnaz and Lorestani, Farnaz and Es’haghi, Zarrin (2018) Silver nanoparticles decorated polyaniline nanocomposite based electrochemical sensor for the determination of anticancer drug 5-fluorouracil. Journal of Pharmaceutical and Biomedical Analysis, 161. pp. 12-19. ISSN 0731-7085, DOI https://doi.org/10.1016/j.jpba.2018.08.004 <https://doi.org/10.1016/j.jpba.2018.08.004>. https://doi.org/10.1016/j.jpba.2018.08.004 doi:10.1016/j.jpba.2018.08.004 |
| spellingShingle | Q Science (General) QD Chemistry Zahed, Fatemeh Modarres Hatamluyi, Behnaz Lorestani, Farnaz Es’haghi, Zarrin Silver nanoparticles decorated polyaniline nanocomposite based electrochemical sensor for the determination of anticancer drug 5-fluorouracil |
| title | Silver nanoparticles decorated polyaniline nanocomposite based electrochemical sensor for the determination of anticancer drug 5-fluorouracil |
| title_full | Silver nanoparticles decorated polyaniline nanocomposite based electrochemical sensor for the determination of anticancer drug 5-fluorouracil |
| title_fullStr | Silver nanoparticles decorated polyaniline nanocomposite based electrochemical sensor for the determination of anticancer drug 5-fluorouracil |
| title_full_unstemmed | Silver nanoparticles decorated polyaniline nanocomposite based electrochemical sensor for the determination of anticancer drug 5-fluorouracil |
| title_short | Silver nanoparticles decorated polyaniline nanocomposite based electrochemical sensor for the determination of anticancer drug 5-fluorouracil |
| title_sort | silver nanoparticles decorated polyaniline nanocomposite based electrochemical sensor for the determination of anticancer drug 5 fluorouracil |
| topic | Q Science (General) QD Chemistry |
| work_keys_str_mv | AT zahedfatemehmodarres silvernanoparticlesdecoratedpolyanilinenanocompositebasedelectrochemicalsensorforthedeterminationofanticancerdrug5fluorouracil AT hatamluyibehnaz silvernanoparticlesdecoratedpolyanilinenanocompositebasedelectrochemicalsensorforthedeterminationofanticancerdrug5fluorouracil AT lorestanifarnaz silvernanoparticlesdecoratedpolyanilinenanocompositebasedelectrochemicalsensorforthedeterminationofanticancerdrug5fluorouracil AT eshaghizarrin silvernanoparticlesdecoratedpolyanilinenanocompositebasedelectrochemicalsensorforthedeterminationofanticancerdrug5fluorouracil |