Coexistence of Colorectal Adenomas and Coronary Calcification in Asymptomatic Men and Women
Goals: Because of shared risk factors between clinically manifest cardiovascular disease and colorectal cancer, we hypothesized the coexistence of subclinical atherosclerosis measured by coronary artery calcium (CAC) and colorectal adenoma (CRA) and that these 2 processes would also share common ris...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Published: |
Lippincott, Williams & Wilkins
2017
|
| Subjects: |
| _version_ | 1825721458951716864 |
|---|---|
| author | Yun, Kyung Eun Chang, Yoosoo Rampal, Sanjay Zhang, Yiyi Cho, Juhee Jung, Hyun Suk Kim, Chan Won Jeong, Chul Cainzos-Achirica, Miguel Zhao, Di Pastor-Barriuso, Roberto Shin, Hocheol Guallar, Eliseo Ryu, Seungho |
| author_facet | Yun, Kyung Eun Chang, Yoosoo Rampal, Sanjay Zhang, Yiyi Cho, Juhee Jung, Hyun Suk Kim, Chan Won Jeong, Chul Cainzos-Achirica, Miguel Zhao, Di Pastor-Barriuso, Roberto Shin, Hocheol Guallar, Eliseo Ryu, Seungho |
| author_sort | Yun, Kyung Eun |
| collection | UM |
| description | Goals: Because of shared risk factors between clinically manifest cardiovascular disease and colorectal cancer, we hypothesized the coexistence of subclinical atherosclerosis measured by coronary artery calcium (CAC) and colorectal adenoma (CRA) and that these 2 processes would also share common risk factors. Background: No study has directly compared the risk factors associated with subclinical coronary atherosclerosis and CRA. Study: This was a cross-sectional study using multinomial logistic regression analysis of 4859 adults who participated in a health screening examination (2010 to 2011; analysis 2014 to 2015). CAC scores were categorized as 0, 1 to 100, or >100. Colonoscopy results were categorized as absent, low-risk, or high-risk CRA. Results: The prevalence of CAC>0, CAC 1 to 100 and >100 was 13.0%, 11.0%, and 2.0%, respectively. The prevalence of any CRA, low-risk CRA, and high-risk CRA was 15.1%, 13.0%, and 2.1%, respectively. The adjusted odds ratios (95% confidence interval) for CAC>0 comparing participants with low-risk and high-risk CRA with those without any CRA were 1.35 (1.06-1.71) and 2.09 (1.29-3.39), respectively. Similarly, the adjusted odds ratios (95% confidence interval) for any CRA comparing participants with CAC 1 to 100 and CAC>100 with those with no CAC were 1.26 (1.00-1.6) and 2.07 (1.31-3.26), respectively. Age, smoking, diabetes, and family history of CRC were significantly associated with both conditions. Conclusions: We observed a graded association between CAC and CRA in apparently healthy individuals. The coexistence of both conditions further emphasizes the need for more evidence of comprehensive approaches to screening and the need to consider the impact of the high risk of coexisting disease in individuals with CAC or CRA, instead of piecemeal approaches restricted to the detection of each disease independently. |
| first_indexed | 2024-03-06T05:50:38Z |
| format | Article |
| id | um.eprints-20243 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:50:38Z |
| publishDate | 2017 |
| publisher | Lippincott, Williams & Wilkins |
| record_format | dspace |
| spelling | um.eprints-202432019-01-30T06:32:31Z http://eprints.um.edu.my/20243/ Coexistence of Colorectal Adenomas and Coronary Calcification in Asymptomatic Men and Women Yun, Kyung Eun Chang, Yoosoo Rampal, Sanjay Zhang, Yiyi Cho, Juhee Jung, Hyun Suk Kim, Chan Won Jeong, Chul Cainzos-Achirica, Miguel Zhao, Di Pastor-Barriuso, Roberto Shin, Hocheol Guallar, Eliseo Ryu, Seungho R Medicine Goals: Because of shared risk factors between clinically manifest cardiovascular disease and colorectal cancer, we hypothesized the coexistence of subclinical atherosclerosis measured by coronary artery calcium (CAC) and colorectal adenoma (CRA) and that these 2 processes would also share common risk factors. Background: No study has directly compared the risk factors associated with subclinical coronary atherosclerosis and CRA. Study: This was a cross-sectional study using multinomial logistic regression analysis of 4859 adults who participated in a health screening examination (2010 to 2011; analysis 2014 to 2015). CAC scores were categorized as 0, 1 to 100, or >100. Colonoscopy results were categorized as absent, low-risk, or high-risk CRA. Results: The prevalence of CAC>0, CAC 1 to 100 and >100 was 13.0%, 11.0%, and 2.0%, respectively. The prevalence of any CRA, low-risk CRA, and high-risk CRA was 15.1%, 13.0%, and 2.1%, respectively. The adjusted odds ratios (95% confidence interval) for CAC>0 comparing participants with low-risk and high-risk CRA with those without any CRA were 1.35 (1.06-1.71) and 2.09 (1.29-3.39), respectively. Similarly, the adjusted odds ratios (95% confidence interval) for any CRA comparing participants with CAC 1 to 100 and CAC>100 with those with no CAC were 1.26 (1.00-1.6) and 2.07 (1.31-3.26), respectively. Age, smoking, diabetes, and family history of CRC were significantly associated with both conditions. Conclusions: We observed a graded association between CAC and CRA in apparently healthy individuals. The coexistence of both conditions further emphasizes the need for more evidence of comprehensive approaches to screening and the need to consider the impact of the high risk of coexisting disease in individuals with CAC or CRA, instead of piecemeal approaches restricted to the detection of each disease independently. Lippincott, Williams & Wilkins 2017 Article PeerReviewed Yun, Kyung Eun and Chang, Yoosoo and Rampal, Sanjay and Zhang, Yiyi and Cho, Juhee and Jung, Hyun Suk and Kim, Chan Won and Jeong, Chul and Cainzos-Achirica, Miguel and Zhao, Di and Pastor-Barriuso, Roberto and Shin, Hocheol and Guallar, Eliseo and Ryu, Seungho (2017) Coexistence of Colorectal Adenomas and Coronary Calcification in Asymptomatic Men and Women. Journal of Clinical Gastroenterology, 52 (6). pp. 508-514. ISSN 0192-0790, DOI https://doi.org/10.1097/MCG.0000000000000824 <https://doi.org/10.1097/MCG.0000000000000824>. https://doi.org/10.1097/MCG.0000000000000824 doi:10.1097/MCG.0000000000000824 |
| spellingShingle | R Medicine Yun, Kyung Eun Chang, Yoosoo Rampal, Sanjay Zhang, Yiyi Cho, Juhee Jung, Hyun Suk Kim, Chan Won Jeong, Chul Cainzos-Achirica, Miguel Zhao, Di Pastor-Barriuso, Roberto Shin, Hocheol Guallar, Eliseo Ryu, Seungho Coexistence of Colorectal Adenomas and Coronary Calcification in Asymptomatic Men and Women |
| title | Coexistence of Colorectal Adenomas and Coronary Calcification in Asymptomatic Men and Women |
| title_full | Coexistence of Colorectal Adenomas and Coronary Calcification in Asymptomatic Men and Women |
| title_fullStr | Coexistence of Colorectal Adenomas and Coronary Calcification in Asymptomatic Men and Women |
| title_full_unstemmed | Coexistence of Colorectal Adenomas and Coronary Calcification in Asymptomatic Men and Women |
| title_short | Coexistence of Colorectal Adenomas and Coronary Calcification in Asymptomatic Men and Women |
| title_sort | coexistence of colorectal adenomas and coronary calcification in asymptomatic men and women |
| topic | R Medicine |
| work_keys_str_mv | AT yunkyungeun coexistenceofcolorectaladenomasandcoronarycalcificationinasymptomaticmenandwomen AT changyoosoo coexistenceofcolorectaladenomasandcoronarycalcificationinasymptomaticmenandwomen AT rampalsanjay coexistenceofcolorectaladenomasandcoronarycalcificationinasymptomaticmenandwomen AT zhangyiyi coexistenceofcolorectaladenomasandcoronarycalcificationinasymptomaticmenandwomen AT chojuhee coexistenceofcolorectaladenomasandcoronarycalcificationinasymptomaticmenandwomen AT junghyunsuk coexistenceofcolorectaladenomasandcoronarycalcificationinasymptomaticmenandwomen AT kimchanwon coexistenceofcolorectaladenomasandcoronarycalcificationinasymptomaticmenandwomen AT jeongchul coexistenceofcolorectaladenomasandcoronarycalcificationinasymptomaticmenandwomen AT cainzosachiricamiguel coexistenceofcolorectaladenomasandcoronarycalcificationinasymptomaticmenandwomen AT zhaodi coexistenceofcolorectaladenomasandcoronarycalcificationinasymptomaticmenandwomen AT pastorbarriusoroberto coexistenceofcolorectaladenomasandcoronarycalcificationinasymptomaticmenandwomen AT shinhocheol coexistenceofcolorectaladenomasandcoronarycalcificationinasymptomaticmenandwomen AT guallareliseo coexistenceofcolorectaladenomasandcoronarycalcificationinasymptomaticmenandwomen AT ryuseungho coexistenceofcolorectaladenomasandcoronarycalcificationinasymptomaticmenandwomen |