Hand, foot and mouth disease: University Malaya Medical Centre experience

The prevalence of HFMD as well as the causative agents was unknown in peninsular Malaysia prior to May 1997. From May 1997 to June 2001, 585 patients suspected to have enterovirus infections, with 467 patients clinically diagnosed as having HFMD, were investigated in the diagnostic virology unit of...

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Main Authors: Hooi, P.S., Chua, B.H., Lee, C.S.M., Lam, S.K., Chua, K.B.
Format: Article
Published: 2002
Subjects:
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author Hooi, P.S.
Chua, B.H.
Lee, C.S.M.
Lam, S.K.
Chua, K.B.
author_facet Hooi, P.S.
Chua, B.H.
Lee, C.S.M.
Lam, S.K.
Chua, K.B.
author_sort Hooi, P.S.
collection UM
description The prevalence of HFMD as well as the causative agents was unknown in peninsular Malaysia prior to May 1997. From May 1997 to June 2001, 585 patients suspected to have enterovirus infections, with 467 patients clinically diagnosed as having HFMD, were investigated in the diagnostic virology unit of the University Malaya Medical Centre. Data from this study showed that HFMD is endemic in Malaysia with the occurrence of two outbreaks during the study period. In each outbreak, a number of viruses were isolated but enterovirus 71 was the man virus isolated in both outbreaks. Echovirus 7 (Eo7) was isolated from 5 patients with HFMD in the second outbreak, a clinical entity that has not been attributed to it previously. Children aged 4 years and below, particularly those between 1 and 2 years of age, were in the main group of patients affected by the illness. HFMD by itself and without neurological involvement was relatively benign and self-limiting. There was no significant difference in the virus isolation rate with respect to gender and ethnic groups. Virus isolation was attempted in a total of 764 clinical specimens consisting of 342 stool specimens, 285 oral secretions specimens and 137 vesicular fluid specimens. Oral specimens gave the highest virus isolation rate (33.3%) followed by vesicular specimens (27.0%). Stool specimens only yielded an isolation rate of 14.0%.
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spelling um.eprints-20282014-12-26T02:48:12Z http://eprints.um.edu.my/2028/ Hand, foot and mouth disease: University Malaya Medical Centre experience Hooi, P.S. Chua, B.H. Lee, C.S.M. Lam, S.K. Chua, K.B. R Medicine The prevalence of HFMD as well as the causative agents was unknown in peninsular Malaysia prior to May 1997. From May 1997 to June 2001, 585 patients suspected to have enterovirus infections, with 467 patients clinically diagnosed as having HFMD, were investigated in the diagnostic virology unit of the University Malaya Medical Centre. Data from this study showed that HFMD is endemic in Malaysia with the occurrence of two outbreaks during the study period. In each outbreak, a number of viruses were isolated but enterovirus 71 was the man virus isolated in both outbreaks. Echovirus 7 (Eo7) was isolated from 5 patients with HFMD in the second outbreak, a clinical entity that has not been attributed to it previously. Children aged 4 years and below, particularly those between 1 and 2 years of age, were in the main group of patients affected by the illness. HFMD by itself and without neurological involvement was relatively benign and self-limiting. There was no significant difference in the virus isolation rate with respect to gender and ethnic groups. Virus isolation was attempted in a total of 764 clinical specimens consisting of 342 stool specimens, 285 oral secretions specimens and 137 vesicular fluid specimens. Oral specimens gave the highest virus isolation rate (33.3%) followed by vesicular specimens (27.0%). Stool specimens only yielded an isolation rate of 14.0%. 2002 Article PeerReviewed Hooi, P.S. and Chua, B.H. and Lee, C.S.M. and Lam, S.K. and Chua, K.B. (2002) Hand, foot and mouth disease: University Malaya Medical Centre experience. Medical Journal of Malaysia, 57 (1). pp. 88-91. ISSN 0300-5283, http://myais.fsktm.um.edu.my/7819/
spellingShingle R Medicine
Hooi, P.S.
Chua, B.H.
Lee, C.S.M.
Lam, S.K.
Chua, K.B.
Hand, foot and mouth disease: University Malaya Medical Centre experience
title Hand, foot and mouth disease: University Malaya Medical Centre experience
title_full Hand, foot and mouth disease: University Malaya Medical Centre experience
title_fullStr Hand, foot and mouth disease: University Malaya Medical Centre experience
title_full_unstemmed Hand, foot and mouth disease: University Malaya Medical Centre experience
title_short Hand, foot and mouth disease: University Malaya Medical Centre experience
title_sort hand foot and mouth disease university malaya medical centre experience
topic R Medicine
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