New sporopollenin-based β-cyclodextrin functionalized magnetic hybrid adsorbent for magnetic solid-phase extraction of nonsteroidal anti-inflammatory drugs from water samples
A magnetic solid-phase extraction (MSPE)procedure on the newly synthesized magnetic β-cyclodextrin functionalized with toluene diisocyanate (TDI)as a linker and further modified with bio-polymeric spores of sporopollenin (MSp-TDI-βCD), was developed for the extraction of nonsteroidal anti-inflammato...
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The Royal Society
2018
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| author | Yaacob, Syed Fariq Fathullah Syed Kamboh, Muhammad Afzal Wan Ibrahim, Wan Aini Mohamad, Sharifah |
| author_facet | Yaacob, Syed Fariq Fathullah Syed Kamboh, Muhammad Afzal Wan Ibrahim, Wan Aini Mohamad, Sharifah |
| author_sort | Yaacob, Syed Fariq Fathullah Syed |
| collection | UM |
| description | A magnetic solid-phase extraction (MSPE)procedure on the newly synthesized magnetic β-cyclodextrin functionalized with toluene diisocyanate (TDI)as a linker and further modified with bio-polymeric spores of sporopollenin (MSp-TDI-βCD), was developed for the extraction of nonsteroidal anti-inflammatory drugs (NSAIDs), namely, indoprofen (INP), ketoprofen (KTP), ibuprofen (IBP)and fenoprofen (FNP)from water samples prior to their HPLC-DAD determination. The newly synthesized MSp-TDI-βCD was comprehensibly characterized using FT-IR, XRD, SEM-EDX, BET and VSM analyses. The separation of selected NSAIDs on MSp-TDI-βCD from aqueous solution was simply achieved by applying an external magnetic field via a permanent magnet. The MSPE parameters affecting extraction performance, i.e. sorbent dosage, sample volume, extraction and desorption time, type of organic eluent and volume and solution pH were investigated and optimized. The proposed method showed linear range between 0.5 and 500 ng ml-1, low limit of detection at S/N=3 (0.16-0.37 ng ml-1)and limit of quantification at S/N=10 (0.53-1.22 ng ml-1). The inter-day (n=15)and intra-day (n=5)precision for the proposed methods given by relative standard deviation (RSD%)was in the range of 2.5-4.0 and 2.1-5.5, respectively. The extraction recoveries of NSAIDs from environmental samples (tap, drinking and river water)ranged from 92.5% to 123.6%, with satisfactory precision (RSD% less than 12.4%). |
| first_indexed | 2024-03-06T05:50:56Z |
| format | Article |
| id | um.eprints-20343 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:50:56Z |
| publishDate | 2018 |
| publisher | The Royal Society |
| record_format | dspace |
| spelling | um.eprints-203432019-02-15T08:55:14Z http://eprints.um.edu.my/20343/ New sporopollenin-based β-cyclodextrin functionalized magnetic hybrid adsorbent for magnetic solid-phase extraction of nonsteroidal anti-inflammatory drugs from water samples Yaacob, Syed Fariq Fathullah Syed Kamboh, Muhammad Afzal Wan Ibrahim, Wan Aini Mohamad, Sharifah Q Science (General) QD Chemistry A magnetic solid-phase extraction (MSPE)procedure on the newly synthesized magnetic β-cyclodextrin functionalized with toluene diisocyanate (TDI)as a linker and further modified with bio-polymeric spores of sporopollenin (MSp-TDI-βCD), was developed for the extraction of nonsteroidal anti-inflammatory drugs (NSAIDs), namely, indoprofen (INP), ketoprofen (KTP), ibuprofen (IBP)and fenoprofen (FNP)from water samples prior to their HPLC-DAD determination. The newly synthesized MSp-TDI-βCD was comprehensibly characterized using FT-IR, XRD, SEM-EDX, BET and VSM analyses. The separation of selected NSAIDs on MSp-TDI-βCD from aqueous solution was simply achieved by applying an external magnetic field via a permanent magnet. The MSPE parameters affecting extraction performance, i.e. sorbent dosage, sample volume, extraction and desorption time, type of organic eluent and volume and solution pH were investigated and optimized. The proposed method showed linear range between 0.5 and 500 ng ml-1, low limit of detection at S/N=3 (0.16-0.37 ng ml-1)and limit of quantification at S/N=10 (0.53-1.22 ng ml-1). The inter-day (n=15)and intra-day (n=5)precision for the proposed methods given by relative standard deviation (RSD%)was in the range of 2.5-4.0 and 2.1-5.5, respectively. The extraction recoveries of NSAIDs from environmental samples (tap, drinking and river water)ranged from 92.5% to 123.6%, with satisfactory precision (RSD% less than 12.4%). The Royal Society 2018 Article PeerReviewed Yaacob, Syed Fariq Fathullah Syed and Kamboh, Muhammad Afzal and Wan Ibrahim, Wan Aini and Mohamad, Sharifah (2018) New sporopollenin-based β-cyclodextrin functionalized magnetic hybrid adsorbent for magnetic solid-phase extraction of nonsteroidal anti-inflammatory drugs from water samples. Royal Society Open Science, 5 (7). p. 171311. ISSN 2054-5703, DOI https://doi.org/10.1098/rsos.171311 <https://doi.org/10.1098/rsos.171311>. https://doi.org/10.1098/rsos.171311 doi:10.1098/rsos.171311 |
| spellingShingle | Q Science (General) QD Chemistry Yaacob, Syed Fariq Fathullah Syed Kamboh, Muhammad Afzal Wan Ibrahim, Wan Aini Mohamad, Sharifah New sporopollenin-based β-cyclodextrin functionalized magnetic hybrid adsorbent for magnetic solid-phase extraction of nonsteroidal anti-inflammatory drugs from water samples |
| title | New sporopollenin-based β-cyclodextrin functionalized magnetic hybrid adsorbent for magnetic solid-phase extraction of nonsteroidal anti-inflammatory drugs from water samples |
| title_full | New sporopollenin-based β-cyclodextrin functionalized magnetic hybrid adsorbent for magnetic solid-phase extraction of nonsteroidal anti-inflammatory drugs from water samples |
| title_fullStr | New sporopollenin-based β-cyclodextrin functionalized magnetic hybrid adsorbent for magnetic solid-phase extraction of nonsteroidal anti-inflammatory drugs from water samples |
| title_full_unstemmed | New sporopollenin-based β-cyclodextrin functionalized magnetic hybrid adsorbent for magnetic solid-phase extraction of nonsteroidal anti-inflammatory drugs from water samples |
| title_short | New sporopollenin-based β-cyclodextrin functionalized magnetic hybrid adsorbent for magnetic solid-phase extraction of nonsteroidal anti-inflammatory drugs from water samples |
| title_sort | new sporopollenin based β cyclodextrin functionalized magnetic hybrid adsorbent for magnetic solid phase extraction of nonsteroidal anti inflammatory drugs from water samples |
| topic | Q Science (General) QD Chemistry |
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