Autochthonous spread of DENV-3 genotype III in Malaysia mitigated by pre-existing homotypic and heterotypic immunity
Dengue virus type 3 genotype III (DENV-3/III) is widely distributed in most dengue-endemic regions. It emerged in Malaysia in 2008 and autochthonously spread in the midst of endemic DENV-3/I circulation. The spread, however, was limited and the virus did not cause any major outbreak. Spatiotemporal...
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| Format: | Article |
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Cambridge University Press
2018
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| author | Tan, Kim Kee Nellis, S. Zulkifle, Nurul Izzani Sulaiman, Syuhaida AbuBakar, Sazaly |
| author_facet | Tan, Kim Kee Nellis, S. Zulkifle, Nurul Izzani Sulaiman, Syuhaida AbuBakar, Sazaly |
| author_sort | Tan, Kim Kee |
| collection | UM |
| description | Dengue virus type 3 genotype III (DENV-3/III) is widely distributed in most dengue-endemic regions. It emerged in Malaysia in 2008 and autochthonously spread in the midst of endemic DENV-3/I circulation. The spread, however, was limited and the virus did not cause any major outbreak. Spatiotemporal distribution study of DENV-3 over the period between 2005 and 2011 revealed that dengue cases involving DENV-3/III occurred mostly in areas without pre-existing circulating DENV-3. Neutralisation assays performed using sera of patients with the respective infection showed that the DENV-3/III viruses can be effectively neutralised by sera of patients with DENV-3 infection (50% foci reduction neutralisation titres (FRNT50) > 1300). Sera of patients with DENV-1 infection (FRNT50 â 190), but not sera of patients with DENV-2 infection (FRNT50 â 50), were also able to neutralise the virus. These findings highlight the possibility that the pre-existing homotypic DENV-3 and the cross-reacting heterotypic DENV-1 antibody responses could play a role in mitigating a major outbreak involving DENV-3/III in the Klang Valley, Malaysia. |
| first_indexed | 2024-03-06T05:51:30Z |
| format | Article |
| id | um.eprints-20538 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:51:30Z |
| publishDate | 2018 |
| publisher | Cambridge University Press |
| record_format | dspace |
| spelling | um.eprints-205382019-02-28T05:21:13Z http://eprints.um.edu.my/20538/ Autochthonous spread of DENV-3 genotype III in Malaysia mitigated by pre-existing homotypic and heterotypic immunity Tan, Kim Kee Nellis, S. Zulkifle, Nurul Izzani Sulaiman, Syuhaida AbuBakar, Sazaly R Medicine Dengue virus type 3 genotype III (DENV-3/III) is widely distributed in most dengue-endemic regions. It emerged in Malaysia in 2008 and autochthonously spread in the midst of endemic DENV-3/I circulation. The spread, however, was limited and the virus did not cause any major outbreak. Spatiotemporal distribution study of DENV-3 over the period between 2005 and 2011 revealed that dengue cases involving DENV-3/III occurred mostly in areas without pre-existing circulating DENV-3. Neutralisation assays performed using sera of patients with the respective infection showed that the DENV-3/III viruses can be effectively neutralised by sera of patients with DENV-3 infection (50% foci reduction neutralisation titres (FRNT50) > 1300). Sera of patients with DENV-1 infection (FRNT50 â 190), but not sera of patients with DENV-2 infection (FRNT50 â 50), were also able to neutralise the virus. These findings highlight the possibility that the pre-existing homotypic DENV-3 and the cross-reacting heterotypic DENV-1 antibody responses could play a role in mitigating a major outbreak involving DENV-3/III in the Klang Valley, Malaysia. Cambridge University Press 2018 Article PeerReviewed Tan, Kim Kee and Nellis, S. and Zulkifle, Nurul Izzani and Sulaiman, Syuhaida and AbuBakar, Sazaly (2018) Autochthonous spread of DENV-3 genotype III in Malaysia mitigated by pre-existing homotypic and heterotypic immunity. Epidemiology and Infection, 146 (13). pp. 1635-1641. ISSN 0950-2688, DOI https://doi.org/10.1017/S0950268818001425 <https://doi.org/10.1017/S0950268818001425>. https://doi.org/10.1017/S0950268818001425 doi:10.1017/S0950268818001425 |
| spellingShingle | R Medicine Tan, Kim Kee Nellis, S. Zulkifle, Nurul Izzani Sulaiman, Syuhaida AbuBakar, Sazaly Autochthonous spread of DENV-3 genotype III in Malaysia mitigated by pre-existing homotypic and heterotypic immunity |
| title | Autochthonous spread of DENV-3 genotype III in Malaysia mitigated by pre-existing homotypic and heterotypic immunity |
| title_full | Autochthonous spread of DENV-3 genotype III in Malaysia mitigated by pre-existing homotypic and heterotypic immunity |
| title_fullStr | Autochthonous spread of DENV-3 genotype III in Malaysia mitigated by pre-existing homotypic and heterotypic immunity |
| title_full_unstemmed | Autochthonous spread of DENV-3 genotype III in Malaysia mitigated by pre-existing homotypic and heterotypic immunity |
| title_short | Autochthonous spread of DENV-3 genotype III in Malaysia mitigated by pre-existing homotypic and heterotypic immunity |
| title_sort | autochthonous spread of denv 3 genotype iii in malaysia mitigated by pre existing homotypic and heterotypic immunity |
| topic | R Medicine |
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