Heterogenous expression of ERG oncoprotein in Malaysian men with adenocarcinoma of the prostate
Introduction: Prostate cancer is a heterogenous disease and the mechanisms that drive it to behave differently are not well understood. Tumour expression of the ERG oncogene occurs in the majority of patients with prostate cancer in Western studies. This is considered to be oncogenic as ERG acts as...
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College of Pathologists, Academy of Medicine Malaysia
2018
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| author | Tan, Jia Shin Jessica Ong, Kien Chai Ong, Diana Bee Lan Razack, Azad Lim, Jasmine Yunus, Rosna Sundram, Murali Rhodes, Anthony |
| author_facet | Tan, Jia Shin Jessica Ong, Kien Chai Ong, Diana Bee Lan Razack, Azad Lim, Jasmine Yunus, Rosna Sundram, Murali Rhodes, Anthony |
| author_sort | Tan, Jia Shin Jessica |
| collection | UM |
| description | Introduction: Prostate cancer is a heterogenous disease and the mechanisms that drive it to behave differently are not well understood. Tumour expression of the ERG oncogene occurs in the majority of patients with prostate cancer in Western studies. This is considered to be oncogenic as ERG acts as a transcription factor to regulate genes involved in tumour proliferation and invasion. In this study we investigated expression of ERG in Malaysian men with prostate cancer. Methods: Tissues were collected from 80 patients with clinically detected prostate cancer and treated with radical prostatectomy. Cases were tested for ERG by immunohistochemistry using the mouse monoclonal antibody EP111. All blocks on 48 cases were tested in order to determine the extent of heterogeneity of ERG expression within individual cases. ERG expression was analysed in relation to patient age, ethnicity and tumour stage and grade. Results: Forty-six percent of cases were ERG positive. There was no significant association between ERG and tumour grade or stage. Sixty-nine percent of Indian patients had ERG positive tumours; this was significantly higher (p=0.031) than for Chinese (40%) and Malay (44%) patients. Heterogeneity of ERG expression, in which both positive and negative clones were present, was seen in 35% of evaluated cases. Evaluation by tumour foci showed younger patients had more ERG positive tumour foci than older patients (p=0.01). Indian patients were more likely to have the majority of tumour foci with ERG staining positively, compared to either Chinese or Malay patients (P <0.01). Conclusion: In this study, tumour expression of ERG was more likely to occur in patients of Indian ethnicity. |
| first_indexed | 2024-03-06T05:51:31Z |
| format | Article |
| id | um.eprints-20541 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:51:31Z |
| publishDate | 2018 |
| publisher | College of Pathologists, Academy of Medicine Malaysia |
| record_format | dspace |
| spelling | um.eprints-205412022-04-12T05:03:07Z http://eprints.um.edu.my/20541/ Heterogenous expression of ERG oncoprotein in Malaysian men with adenocarcinoma of the prostate Tan, Jia Shin Jessica Ong, Kien Chai Ong, Diana Bee Lan Razack, Azad Lim, Jasmine Yunus, Rosna Sundram, Murali Rhodes, Anthony R Medicine Introduction: Prostate cancer is a heterogenous disease and the mechanisms that drive it to behave differently are not well understood. Tumour expression of the ERG oncogene occurs in the majority of patients with prostate cancer in Western studies. This is considered to be oncogenic as ERG acts as a transcription factor to regulate genes involved in tumour proliferation and invasion. In this study we investigated expression of ERG in Malaysian men with prostate cancer. Methods: Tissues were collected from 80 patients with clinically detected prostate cancer and treated with radical prostatectomy. Cases were tested for ERG by immunohistochemistry using the mouse monoclonal antibody EP111. All blocks on 48 cases were tested in order to determine the extent of heterogeneity of ERG expression within individual cases. ERG expression was analysed in relation to patient age, ethnicity and tumour stage and grade. Results: Forty-six percent of cases were ERG positive. There was no significant association between ERG and tumour grade or stage. Sixty-nine percent of Indian patients had ERG positive tumours; this was significantly higher (p=0.031) than for Chinese (40%) and Malay (44%) patients. Heterogeneity of ERG expression, in which both positive and negative clones were present, was seen in 35% of evaluated cases. Evaluation by tumour foci showed younger patients had more ERG positive tumour foci than older patients (p=0.01). Indian patients were more likely to have the majority of tumour foci with ERG staining positively, compared to either Chinese or Malay patients (P <0.01). Conclusion: In this study, tumour expression of ERG was more likely to occur in patients of Indian ethnicity. College of Pathologists, Academy of Medicine Malaysia 2018 Article PeerReviewed Tan, Jia Shin Jessica and Ong, Kien Chai and Ong, Diana Bee Lan and Razack, Azad and Lim, Jasmine and Yunus, Rosna and Sundram, Murali and Rhodes, Anthony (2018) Heterogenous expression of ERG oncoprotein in Malaysian men with adenocarcinoma of the prostate. Malaysian Journal of Pathology, 40 (2). pp. 103-110. ISSN 0126-8635, http://www.mjpath.org.my/2018/v40n2/adenocarcinoma-of-prostate.pdf |
| spellingShingle | R Medicine Tan, Jia Shin Jessica Ong, Kien Chai Ong, Diana Bee Lan Razack, Azad Lim, Jasmine Yunus, Rosna Sundram, Murali Rhodes, Anthony Heterogenous expression of ERG oncoprotein in Malaysian men with adenocarcinoma of the prostate |
| title | Heterogenous expression of ERG oncoprotein in Malaysian men with adenocarcinoma of the prostate |
| title_full | Heterogenous expression of ERG oncoprotein in Malaysian men with adenocarcinoma of the prostate |
| title_fullStr | Heterogenous expression of ERG oncoprotein in Malaysian men with adenocarcinoma of the prostate |
| title_full_unstemmed | Heterogenous expression of ERG oncoprotein in Malaysian men with adenocarcinoma of the prostate |
| title_short | Heterogenous expression of ERG oncoprotein in Malaysian men with adenocarcinoma of the prostate |
| title_sort | heterogenous expression of erg oncoprotein in malaysian men with adenocarcinoma of the prostate |
| topic | R Medicine |
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