Styryl lactones from roots and barks goniothalamus lanceolatus
A new styryl lactone, 5R,6R-5-hydroxy-6-styryltetrahydropyrane-2-one 2 was isolated from the roots of an endemic Goniothalamus lanceolatus Miq. of Sarawak, Malaysia. Furthermore, seven previously undescribed diastereomers, 5R,6R-5-hydroxygoniothalamin 3, 5R,6R-5-acetylgoniothalamin 4, 6S,7S,8S-gonio...
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| Format: | Article |
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SAGE Publications
2018
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| _version_ | 1796961332090634240 |
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| author | Rasol, Nurulfazlina Edayah Ahmad, Fasihuddin Badruddin Mai, Chun Wai Bihud, Nur Vicky Abdullah, Fauziah Hanum Awang, Khalijah Ismail, Nor Hadiani |
| author_facet | Rasol, Nurulfazlina Edayah Ahmad, Fasihuddin Badruddin Mai, Chun Wai Bihud, Nur Vicky Abdullah, Fauziah Hanum Awang, Khalijah Ismail, Nor Hadiani |
| author_sort | Rasol, Nurulfazlina Edayah |
| collection | UM |
| description | A new styryl lactone, 5R,6R-5-hydroxy-6-styryltetrahydropyrane-2-one 2 was isolated from the roots of an endemic Goniothalamus lanceolatus Miq. of Sarawak, Malaysia. Furthermore, seven previously undescribed diastereomers, 5R,6R-5-hydroxygoniothalamin 3, 5R,6R-5-acetylgoniothalamin 4, 6S,7S,8S-goniodiol-7-monoacetate 5, 6S,7S,8S-goniodiol-8-monoacetate 6, goniofupyrone B 7, deoxygoniopypyrone B 8 and 1S,5S,7R,8S,3-endo,7-endo-(+)-8-epi-9-deoxygoniopypyrone acetate 9, along with six known styryl lactones (1, 10-15) were also isolated and characterized. 6S-goniothalamin 1 is reported for the first time from a Goniothalamus species. 1, 11 and 12 showed cytotoxic activity against human colon and lung cancer cell lines with IC 50 values ranging from 2.38-7.59 µM. |
| first_indexed | 2024-03-06T05:52:39Z |
| format | Article |
| id | um.eprints-20912 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:52:39Z |
| publishDate | 2018 |
| publisher | SAGE Publications |
| record_format | dspace |
| spelling | um.eprints-209122019-04-16T01:41:11Z http://eprints.um.edu.my/20912/ Styryl lactones from roots and barks goniothalamus lanceolatus Rasol, Nurulfazlina Edayah Ahmad, Fasihuddin Badruddin Mai, Chun Wai Bihud, Nur Vicky Abdullah, Fauziah Hanum Awang, Khalijah Ismail, Nor Hadiani Q Science (General) QD Chemistry A new styryl lactone, 5R,6R-5-hydroxy-6-styryltetrahydropyrane-2-one 2 was isolated from the roots of an endemic Goniothalamus lanceolatus Miq. of Sarawak, Malaysia. Furthermore, seven previously undescribed diastereomers, 5R,6R-5-hydroxygoniothalamin 3, 5R,6R-5-acetylgoniothalamin 4, 6S,7S,8S-goniodiol-7-monoacetate 5, 6S,7S,8S-goniodiol-8-monoacetate 6, goniofupyrone B 7, deoxygoniopypyrone B 8 and 1S,5S,7R,8S,3-endo,7-endo-(+)-8-epi-9-deoxygoniopypyrone acetate 9, along with six known styryl lactones (1, 10-15) were also isolated and characterized. 6S-goniothalamin 1 is reported for the first time from a Goniothalamus species. 1, 11 and 12 showed cytotoxic activity against human colon and lung cancer cell lines with IC 50 values ranging from 2.38-7.59 µM. SAGE Publications 2018 Article PeerReviewed Rasol, Nurulfazlina Edayah and Ahmad, Fasihuddin Badruddin and Mai, Chun Wai and Bihud, Nur Vicky and Abdullah, Fauziah Hanum and Awang, Khalijah and Ismail, Nor Hadiani (2018) Styryl lactones from roots and barks goniothalamus lanceolatus. Natural Product Communications, 13 (12). pp. 1575-1578. ISSN 1934-578X, https://journals.sagepub.com/doi/pdf/10.1177/1934578X1801301203 |
| spellingShingle | Q Science (General) QD Chemistry Rasol, Nurulfazlina Edayah Ahmad, Fasihuddin Badruddin Mai, Chun Wai Bihud, Nur Vicky Abdullah, Fauziah Hanum Awang, Khalijah Ismail, Nor Hadiani Styryl lactones from roots and barks goniothalamus lanceolatus |
| title | Styryl lactones from roots and barks goniothalamus lanceolatus |
| title_full | Styryl lactones from roots and barks goniothalamus lanceolatus |
| title_fullStr | Styryl lactones from roots and barks goniothalamus lanceolatus |
| title_full_unstemmed | Styryl lactones from roots and barks goniothalamus lanceolatus |
| title_short | Styryl lactones from roots and barks goniothalamus lanceolatus |
| title_sort | styryl lactones from roots and barks goniothalamus lanceolatus |
| topic | Q Science (General) QD Chemistry |
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