Bisleuconothines B–D, Modified Eburnane–Aspidosperma Bisindole Alkaloids from Leuconotis griffithii
Three new bisindole alkaloids, bisleuconothines B-D (1-3), were isolated from the bark of Leuconotis griffithii. Their structures were elucidated by 1D and 2D NMR spectroscopy and DFT calculations. Bisleuconothine B (1) is the first monoterpene indole alkaloid dimer featuring bridges between both C-...
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| Format: | Article |
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American Chemical Society
2018
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| _version_ | 1796961364335394816 |
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| author | Nugroho, Alfarius Eko Zhang, Wenjia Hirasawa, Yusuke Tang, Yiming Wong, Chin Piow Kaneda, Toshio A. Hadi, A. Hamid Morita, Hiroshi |
| author_facet | Nugroho, Alfarius Eko Zhang, Wenjia Hirasawa, Yusuke Tang, Yiming Wong, Chin Piow Kaneda, Toshio A. Hadi, A. Hamid Morita, Hiroshi |
| author_sort | Nugroho, Alfarius Eko |
| collection | UM |
| description | Three new bisindole alkaloids, bisleuconothines B-D (1-3), were isolated from the bark of Leuconotis griffithii. Their structures were elucidated by 1D and 2D NMR spectroscopy and DFT calculations. Bisleuconothine B (1) is the first monoterpene indole alkaloid dimer featuring bridges between both C-16-C-10′ and C-2-O-C-9′. All compounds were deemed noncytotoxic (IC50 > 10 μM) when tested against A549 human lung adenocarcinoma cells. |
| first_indexed | 2024-03-06T05:53:09Z |
| format | Article |
| id | um.eprints-21094 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:53:09Z |
| publishDate | 2018 |
| publisher | American Chemical Society |
| record_format | dspace |
| spelling | um.eprints-210942021-09-02T04:24:15Z http://eprints.um.edu.my/21094/ Bisleuconothines B–D, Modified Eburnane–Aspidosperma Bisindole Alkaloids from Leuconotis griffithii Nugroho, Alfarius Eko Zhang, Wenjia Hirasawa, Yusuke Tang, Yiming Wong, Chin Piow Kaneda, Toshio A. Hadi, A. Hamid Morita, Hiroshi Q Science (General) QD Chemistry Three new bisindole alkaloids, bisleuconothines B-D (1-3), were isolated from the bark of Leuconotis griffithii. Their structures were elucidated by 1D and 2D NMR spectroscopy and DFT calculations. Bisleuconothine B (1) is the first monoterpene indole alkaloid dimer featuring bridges between both C-16-C-10′ and C-2-O-C-9′. All compounds were deemed noncytotoxic (IC50 > 10 μM) when tested against A549 human lung adenocarcinoma cells. American Chemical Society 2018 Article PeerReviewed Nugroho, Alfarius Eko and Zhang, Wenjia and Hirasawa, Yusuke and Tang, Yiming and Wong, Chin Piow and Kaneda, Toshio and A. Hadi, A. Hamid and Morita, Hiroshi (2018) Bisleuconothines B–D, Modified Eburnane–Aspidosperma Bisindole Alkaloids from Leuconotis griffithii. Journal of Natural Products, 81 (11). pp. 2600-2604. ISSN 0163-3864, DOI https://doi.org/10.1021/acs.jnatprod.8b00749 <https://doi.org/10.1021/acs.jnatprod.8b00749>. https://doi.org/10.1021/acs.jnatprod.8b00749 doi:10.1021/acs.jnatprod.8b00749 |
| spellingShingle | Q Science (General) QD Chemistry Nugroho, Alfarius Eko Zhang, Wenjia Hirasawa, Yusuke Tang, Yiming Wong, Chin Piow Kaneda, Toshio A. Hadi, A. Hamid Morita, Hiroshi Bisleuconothines B–D, Modified Eburnane–Aspidosperma Bisindole Alkaloids from Leuconotis griffithii |
| title | Bisleuconothines B–D, Modified Eburnane–Aspidosperma Bisindole Alkaloids from Leuconotis griffithii |
| title_full | Bisleuconothines B–D, Modified Eburnane–Aspidosperma Bisindole Alkaloids from Leuconotis griffithii |
| title_fullStr | Bisleuconothines B–D, Modified Eburnane–Aspidosperma Bisindole Alkaloids from Leuconotis griffithii |
| title_full_unstemmed | Bisleuconothines B–D, Modified Eburnane–Aspidosperma Bisindole Alkaloids from Leuconotis griffithii |
| title_short | Bisleuconothines B–D, Modified Eburnane–Aspidosperma Bisindole Alkaloids from Leuconotis griffithii |
| title_sort | bisleuconothines b d modified eburnane aspidosperma bisindole alkaloids from leuconotis griffithii |
| topic | Q Science (General) QD Chemistry |
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