Enantiomeric pairs of copper(II) polypyridyl-alanine complex salts: anticancer studies
The anticancer properties of two previously characterized pairs of optically pure chiral complex salts [Cu(phen)(ala)(H2O)]X·xH2O (phen = 1.10-phenanthroline; X = NO3 −; ala: l-alanine (l-ala) 1 and d-alanine (d-ala) 2; and (X = Cl−; ala: l-ala, 3 and d-ala, 4; x = number of lattice water molecules)...
| المؤلفون الرئيسيون: | , , , , , , |
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| التنسيق: | مقال |
| منشور في: |
Springer Verlag
2018
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| الموضوعات: |
| _version_ | 1825721631376408576 |
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| author | Ng, Pei Ying Chye, Soi Moi Tiong, Yee Liang Chan, Cheang Wei Tan, Kong Wai Ooi, Ing Hong Ng, Chew Hee |
| author_facet | Ng, Pei Ying Chye, Soi Moi Tiong, Yee Liang Chan, Cheang Wei Tan, Kong Wai Ooi, Ing Hong Ng, Chew Hee |
| author_sort | Ng, Pei Ying |
| collection | UM |
| description | The anticancer properties of two previously characterized pairs of optically pure chiral complex salts [Cu(phen)(ala)(H2O)]X·xH2O (phen = 1.10-phenanthroline; X = NO3 −; ala: l-alanine (l-ala) 1 and d-alanine (d-ala) 2; and (X = Cl−; ala: l-ala, 3 and d-ala, 4; x = number of lattice water molecules) are reported herein, together with the crystal structure of the d-enantiomer 4. Unlike cisplatin which is ineffective against MCF-7 cancer cells with the absence of caspase-3 protein expression, these two pairs of complex salts were effective against this cell line and they were able to induce an increase in intracellular ROS, loss in mitochondrial membrane potential, cell cycle arrest mainly at SubG1 phase , caspase-9 activation, and caspase-3/caspase-7-independent apoptosis. Screening of 1 on the NCI-60 panel of human cancer cell lines showed that it was effective against most of the cell lines. MTT-NCI modified assay screening was also done on other cancer cell lines, viz. A549, CNE1, and HepG2, and two normal cell lines, viz. MCF-10A and CHANG. The effects of chirality of these Cu(II) compounds, especially the greater selectivity of d-enantiomers over the l-counterparts, on their anticancer properties are also reported herein. |
| first_indexed | 2024-03-06T05:53:17Z |
| format | Article |
| id | um.eprints-21141 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:53:17Z |
| publishDate | 2018 |
| publisher | Springer Verlag |
| record_format | dspace |
| spelling | um.eprints-211412019-05-07T06:40:42Z http://eprints.um.edu.my/21141/ Enantiomeric pairs of copper(II) polypyridyl-alanine complex salts: anticancer studies Ng, Pei Ying Chye, Soi Moi Tiong, Yee Liang Chan, Cheang Wei Tan, Kong Wai Ooi, Ing Hong Ng, Chew Hee Q Science (General) QD Chemistry The anticancer properties of two previously characterized pairs of optically pure chiral complex salts [Cu(phen)(ala)(H2O)]X·xH2O (phen = 1.10-phenanthroline; X = NO3 −; ala: l-alanine (l-ala) 1 and d-alanine (d-ala) 2; and (X = Cl−; ala: l-ala, 3 and d-ala, 4; x = number of lattice water molecules) are reported herein, together with the crystal structure of the d-enantiomer 4. Unlike cisplatin which is ineffective against MCF-7 cancer cells with the absence of caspase-3 protein expression, these two pairs of complex salts were effective against this cell line and they were able to induce an increase in intracellular ROS, loss in mitochondrial membrane potential, cell cycle arrest mainly at SubG1 phase , caspase-9 activation, and caspase-3/caspase-7-independent apoptosis. Screening of 1 on the NCI-60 panel of human cancer cell lines showed that it was effective against most of the cell lines. MTT-NCI modified assay screening was also done on other cancer cell lines, viz. A549, CNE1, and HepG2, and two normal cell lines, viz. MCF-10A and CHANG. The effects of chirality of these Cu(II) compounds, especially the greater selectivity of d-enantiomers over the l-counterparts, on their anticancer properties are also reported herein. Springer Verlag 2018 Article PeerReviewed Ng, Pei Ying and Chye, Soi Moi and Tiong, Yee Liang and Chan, Cheang Wei and Tan, Kong Wai and Ooi, Ing Hong and Ng, Chew Hee (2018) Enantiomeric pairs of copper(II) polypyridyl-alanine complex salts: anticancer studies. Transition Metal Chemistry, 43 (6). pp. 479-496. ISSN 0340-4285, DOI https://doi.org/10.1007/s11243-018-0234-4 <https://doi.org/10.1007/s11243-018-0234-4>. https://doi.org/10.1007/s11243-018-0234-4 doi:10.1007/s11243-018-0234-4 |
| spellingShingle | Q Science (General) QD Chemistry Ng, Pei Ying Chye, Soi Moi Tiong, Yee Liang Chan, Cheang Wei Tan, Kong Wai Ooi, Ing Hong Ng, Chew Hee Enantiomeric pairs of copper(II) polypyridyl-alanine complex salts: anticancer studies |
| title | Enantiomeric pairs of copper(II) polypyridyl-alanine complex salts: anticancer studies |
| title_full | Enantiomeric pairs of copper(II) polypyridyl-alanine complex salts: anticancer studies |
| title_fullStr | Enantiomeric pairs of copper(II) polypyridyl-alanine complex salts: anticancer studies |
| title_full_unstemmed | Enantiomeric pairs of copper(II) polypyridyl-alanine complex salts: anticancer studies |
| title_short | Enantiomeric pairs of copper(II) polypyridyl-alanine complex salts: anticancer studies |
| title_sort | enantiomeric pairs of copper ii polypyridyl alanine complex salts anticancer studies |
| topic | Q Science (General) QD Chemistry |
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