Liposomes as colloidal nanovehicles: on the road to success in intravenous drug delivery
The advancement of research in colloidal systems has led to the increased application of this technology in more effective and targeted drug delivery. Nanotechnology enables control over functionality parameters and allows innovations in biodegradable, biocompatible, and stimuli-responsive delivery...
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| Format: | Article |
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De Gruyter
2018
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| _version_ | 1796961380347150336 |
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| author | Naeem, Sumaira Viswanathan, Geetha Misran, Misni |
| author_facet | Naeem, Sumaira Viswanathan, Geetha Misran, Misni |
| author_sort | Naeem, Sumaira |
| collection | UM |
| description | The advancement of research in colloidal systems has led to the increased application of this technology in more effective and targeted drug delivery. Nanotechnology enables control over functionality parameters and allows innovations in biodegradable, biocompatible, and stimuli-responsive delivery systems. The first closed bilayer phospholipid system, the liposome system, has been making steady progress over five decades of extensive research and has been efficient in achieving many desirable parameters such as remote drug loading, size-controlling measures, longer circulation half-lives, and triggered release. Liposome-mediated drug delivery has been successful in overcoming obstacles to cellular and tissue uptake of drugs with improved biodistribution in vitro and in vivo. These colloidal nanovehicles have moved on from a mere concept to clinical applications in various drug delivery systems for antifungal, antibiotic, and anticancer drugs. |
| first_indexed | 2024-03-06T05:53:23Z |
| format | Article |
| id | um.eprints-21176 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:53:23Z |
| publishDate | 2018 |
| publisher | De Gruyter |
| record_format | dspace |
| spelling | um.eprints-211762019-05-08T07:57:10Z http://eprints.um.edu.my/21176/ Liposomes as colloidal nanovehicles: on the road to success in intravenous drug delivery Naeem, Sumaira Viswanathan, Geetha Misran, Misni Q Science (General) QD Chemistry R Medicine The advancement of research in colloidal systems has led to the increased application of this technology in more effective and targeted drug delivery. Nanotechnology enables control over functionality parameters and allows innovations in biodegradable, biocompatible, and stimuli-responsive delivery systems. The first closed bilayer phospholipid system, the liposome system, has been making steady progress over five decades of extensive research and has been efficient in achieving many desirable parameters such as remote drug loading, size-controlling measures, longer circulation half-lives, and triggered release. Liposome-mediated drug delivery has been successful in overcoming obstacles to cellular and tissue uptake of drugs with improved biodistribution in vitro and in vivo. These colloidal nanovehicles have moved on from a mere concept to clinical applications in various drug delivery systems for antifungal, antibiotic, and anticancer drugs. De Gruyter 2018 Article PeerReviewed Naeem, Sumaira and Viswanathan, Geetha and Misran, Misni (2018) Liposomes as colloidal nanovehicles: on the road to success in intravenous drug delivery. Reviews in Chemical Engineering, 34 (3). pp. 365-383. ISSN 0167-8299, DOI https://doi.org/10.1515/revce-2016-0018 <https://doi.org/10.1515/revce-2016-0018>. https://doi.org/10.1515/revce-2016-0018 doi:10.1515/revce-2016-0018 |
| spellingShingle | Q Science (General) QD Chemistry R Medicine Naeem, Sumaira Viswanathan, Geetha Misran, Misni Liposomes as colloidal nanovehicles: on the road to success in intravenous drug delivery |
| title | Liposomes as colloidal nanovehicles: on the road to success in intravenous drug delivery |
| title_full | Liposomes as colloidal nanovehicles: on the road to success in intravenous drug delivery |
| title_fullStr | Liposomes as colloidal nanovehicles: on the road to success in intravenous drug delivery |
| title_full_unstemmed | Liposomes as colloidal nanovehicles: on the road to success in intravenous drug delivery |
| title_short | Liposomes as colloidal nanovehicles: on the road to success in intravenous drug delivery |
| title_sort | liposomes as colloidal nanovehicles on the road to success in intravenous drug delivery |
| topic | Q Science (General) QD Chemistry R Medicine |
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