Vitamin D deficiency is associated with ethnicity and knee pain in a multi-ethnic South-East Asian nation: Results from Malaysian Elders Longitudinal Research (MELoR)
Aim: To determine the association between vitamin D and knee pain among participants of the Malaysian Elders Longitudinal Research (MELoR) study. Method: This was a cross-sectional study from the MELoR study consisting of a representative group of 1011 community-dwelling older persons (57% female),...
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Wiley
2018
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| author | Mat, Sumaiyah Jaafar, Mohamad Hasif Sockalingam, Sargunan Raja, Jasmin Kamaruzzaman, Shahrul Bahyah Chin, Ai-Vyrn Abbas, Azlina Amir Chan, Chee Ken Hairi, Noran Naqiah Othman, Sajaratulnisah Cumming, Robert Tan, Maw Pin |
| author_facet | Mat, Sumaiyah Jaafar, Mohamad Hasif Sockalingam, Sargunan Raja, Jasmin Kamaruzzaman, Shahrul Bahyah Chin, Ai-Vyrn Abbas, Azlina Amir Chan, Chee Ken Hairi, Noran Naqiah Othman, Sajaratulnisah Cumming, Robert Tan, Maw Pin |
| author_sort | Mat, Sumaiyah |
| collection | UM |
| description | Aim: To determine the association between vitamin D and knee pain among participants of the Malaysian Elders Longitudinal Research (MELoR) study. Method: This was a cross-sectional study from the MELoR study consisting of a representative group of 1011 community-dwelling older persons (57% female), mean age 86.5 (54–94) years; 313 were Malays, 367 Chinese and 330 Indians. Participants were asked if they had knee pain. Levels of serum 25-hydroxy cholecalciferol (25-[OH]D), an indicator of vitamin D status, were measured using routine laboratory techniques. Results: In unadjusted analysis, presence of knee pain was significantly associated with vitamin D deficiency (odds ratio [OR] 1.42; 95% confidence interval (CI) 1.08–1.85, P 0.011). Vitamin D levels were significantly associated with ethnicity differences where Malays (OR 7.08; 95% CI 4.94–10.15) and Indians (OR 6.10; 95% CI 4.28–9.71) have lower levels of vitamin D compared to Chinese. Subsequent multivariate analysis revealed that the association between vitamin D deficiency and knee pain was confounded by ethnic differences. Conclusion: A previous study suggested that vitamin D deficiency was associated with knee pain. This relationship was reproduced in our study, but we further established that the association was explained by ethnic variations. As vitamin D status is dependent on skin tone, diet and sunlight exposure, which are all effected by ethnicity, future studies are now required to determine whether a true relationship exists between vitamin D and knee pain. |
| first_indexed | 2024-03-06T05:53:48Z |
| format | Article |
| id | um.eprints-21317 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:53:48Z |
| publishDate | 2018 |
| publisher | Wiley |
| record_format | dspace |
| spelling | um.eprints-213172019-05-27T04:04:32Z http://eprints.um.edu.my/21317/ Vitamin D deficiency is associated with ethnicity and knee pain in a multi-ethnic South-East Asian nation: Results from Malaysian Elders Longitudinal Research (MELoR) Mat, Sumaiyah Jaafar, Mohamad Hasif Sockalingam, Sargunan Raja, Jasmin Kamaruzzaman, Shahrul Bahyah Chin, Ai-Vyrn Abbas, Azlina Amir Chan, Chee Ken Hairi, Noran Naqiah Othman, Sajaratulnisah Cumming, Robert Tan, Maw Pin R Medicine Aim: To determine the association between vitamin D and knee pain among participants of the Malaysian Elders Longitudinal Research (MELoR) study. Method: This was a cross-sectional study from the MELoR study consisting of a representative group of 1011 community-dwelling older persons (57% female), mean age 86.5 (54–94) years; 313 were Malays, 367 Chinese and 330 Indians. Participants were asked if they had knee pain. Levels of serum 25-hydroxy cholecalciferol (25-[OH]D), an indicator of vitamin D status, were measured using routine laboratory techniques. Results: In unadjusted analysis, presence of knee pain was significantly associated with vitamin D deficiency (odds ratio [OR] 1.42; 95% confidence interval (CI) 1.08–1.85, P 0.011). Vitamin D levels were significantly associated with ethnicity differences where Malays (OR 7.08; 95% CI 4.94–10.15) and Indians (OR 6.10; 95% CI 4.28–9.71) have lower levels of vitamin D compared to Chinese. Subsequent multivariate analysis revealed that the association between vitamin D deficiency and knee pain was confounded by ethnic differences. Conclusion: A previous study suggested that vitamin D deficiency was associated with knee pain. This relationship was reproduced in our study, but we further established that the association was explained by ethnic variations. As vitamin D status is dependent on skin tone, diet and sunlight exposure, which are all effected by ethnicity, future studies are now required to determine whether a true relationship exists between vitamin D and knee pain. Wiley 2018 Article PeerReviewed Mat, Sumaiyah and Jaafar, Mohamad Hasif and Sockalingam, Sargunan and Raja, Jasmin and Kamaruzzaman, Shahrul Bahyah and Chin, Ai-Vyrn and Abbas, Azlina Amir and Chan, Chee Ken and Hairi, Noran Naqiah and Othman, Sajaratulnisah and Cumming, Robert and Tan, Maw Pin (2018) Vitamin D deficiency is associated with ethnicity and knee pain in a multi-ethnic South-East Asian nation: Results from Malaysian Elders Longitudinal Research (MELoR). International Journal of Rheumatic Diseases, 21 (5). pp. 930-936. ISSN 1756-1841, DOI https://doi.org/10.1111/1756-185X.13279 <https://doi.org/10.1111/1756-185X.13279>. https://doi.org/10.1111/1756-185X.13279 doi:10.1111/1756-185X.13279 |
| spellingShingle | R Medicine Mat, Sumaiyah Jaafar, Mohamad Hasif Sockalingam, Sargunan Raja, Jasmin Kamaruzzaman, Shahrul Bahyah Chin, Ai-Vyrn Abbas, Azlina Amir Chan, Chee Ken Hairi, Noran Naqiah Othman, Sajaratulnisah Cumming, Robert Tan, Maw Pin Vitamin D deficiency is associated with ethnicity and knee pain in a multi-ethnic South-East Asian nation: Results from Malaysian Elders Longitudinal Research (MELoR) |
| title | Vitamin D deficiency is associated with ethnicity and knee pain in a multi-ethnic South-East Asian nation: Results from Malaysian Elders Longitudinal Research (MELoR) |
| title_full | Vitamin D deficiency is associated with ethnicity and knee pain in a multi-ethnic South-East Asian nation: Results from Malaysian Elders Longitudinal Research (MELoR) |
| title_fullStr | Vitamin D deficiency is associated with ethnicity and knee pain in a multi-ethnic South-East Asian nation: Results from Malaysian Elders Longitudinal Research (MELoR) |
| title_full_unstemmed | Vitamin D deficiency is associated with ethnicity and knee pain in a multi-ethnic South-East Asian nation: Results from Malaysian Elders Longitudinal Research (MELoR) |
| title_short | Vitamin D deficiency is associated with ethnicity and knee pain in a multi-ethnic South-East Asian nation: Results from Malaysian Elders Longitudinal Research (MELoR) |
| title_sort | vitamin d deficiency is associated with ethnicity and knee pain in a multi ethnic south east asian nation results from malaysian elders longitudinal research melor |
| topic | R Medicine |
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