The role of SNPs in the α-chain of the IL-7R gene in CD4+ T-cell recovery in HIV-infected African patients receiving suppressive cART
We previously found an association between faster CD4+ T-cell recovery in HIV-infected patients receiving combination antiretroviral therapy (cART) and interleukin-7 receptor-α (IL-7Rα) haplotype-2 in a predominantly Caucasian cohort. This study aims to determine whether this association was also si...
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2011
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| author | Rajasuriar, R. Booth, D.R. Gouillou, M. Spelman, T. James, I. Solomon, A. Chua, K. Stewart, G. Deeks, S. Bangsberg, D.R. Muzoora, C. Cameron, P.U. Hunt, P. Martin, J. Lewin, S.R. |
| author_facet | Rajasuriar, R. Booth, D.R. Gouillou, M. Spelman, T. James, I. Solomon, A. Chua, K. Stewart, G. Deeks, S. Bangsberg, D.R. Muzoora, C. Cameron, P.U. Hunt, P. Martin, J. Lewin, S.R. |
| author_sort | Rajasuriar, R. |
| collection | UM |
| description | We previously found an association between faster CD4+ T-cell recovery in HIV-infected patients receiving combination antiretroviral therapy (cART) and interleukin-7 receptor-α (IL-7Rα) haplotype-2 in a predominantly Caucasian cohort. This study aims to determine whether this association was also significant in Africans. Patients were recruited from the Uganda AIDS Rural Treatment Outcomes (UARTO) cohort (n=352). We used survival analysis and linear mixed modelling (LMM) to determine factors associated with CD4 T-cell recovery. Eight IL-7Rα single-nucleotide polymorphisms (SNPs) were genotyped in both Africans and Caucasians (n=57). Soluble (s)IL-7Rα levels were measured by ELISA. In UARTO, IL-7Rα haplotype-2 was associated with slower CD4 T-cell recovery following cART by using survival analysis (P=0.020) and no association was found with LMM (P=0.958). The tagging-SNP for IL-7Rα haplotype-2 (rs6897932) was associated with decreased sIL-7Rα (P<0.001). The haplotypes for the IL-7Rα were significantly different in Africans and Caucasians. Using IL-7Rα genotypes we found slower CD4 T-cell recovery in UARTO patients was still associated with rs6897932 (P=0.009) and rs3194051 was associated with faster CD4 T-cell recovery (P=0.006). Unlike Caucasians, we did not demonstrate a significant association between IL-7Rα haplotype 2 and faster CD4 T-cell recovery in Africans. The IL-7Rα SNPs associated with CD4 T-cell recovery following cART differ in African and Caucasian cohorts.Genes and Immunity advance online publication, 22 September 2011; doi:10.1038/gene.2011.65. |
| first_indexed | 2024-03-06T05:07:24Z |
| format | Article |
| id | um.eprints-2149 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:07:24Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | um.eprints-21492013-12-11T03:06:49Z http://eprints.um.edu.my/2149/ The role of SNPs in the α-chain of the IL-7R gene in CD4+ T-cell recovery in HIV-infected African patients receiving suppressive cART Rajasuriar, R. Booth, D.R. Gouillou, M. Spelman, T. James, I. Solomon, A. Chua, K. Stewart, G. Deeks, S. Bangsberg, D.R. Muzoora, C. Cameron, P.U. Hunt, P. Martin, J. Lewin, S.R. R Medicine We previously found an association between faster CD4+ T-cell recovery in HIV-infected patients receiving combination antiretroviral therapy (cART) and interleukin-7 receptor-α (IL-7Rα) haplotype-2 in a predominantly Caucasian cohort. This study aims to determine whether this association was also significant in Africans. Patients were recruited from the Uganda AIDS Rural Treatment Outcomes (UARTO) cohort (n=352). We used survival analysis and linear mixed modelling (LMM) to determine factors associated with CD4 T-cell recovery. Eight IL-7Rα single-nucleotide polymorphisms (SNPs) were genotyped in both Africans and Caucasians (n=57). Soluble (s)IL-7Rα levels were measured by ELISA. In UARTO, IL-7Rα haplotype-2 was associated with slower CD4 T-cell recovery following cART by using survival analysis (P=0.020) and no association was found with LMM (P=0.958). The tagging-SNP for IL-7Rα haplotype-2 (rs6897932) was associated with decreased sIL-7Rα (P<0.001). The haplotypes for the IL-7Rα were significantly different in Africans and Caucasians. Using IL-7Rα genotypes we found slower CD4 T-cell recovery in UARTO patients was still associated with rs6897932 (P=0.009) and rs3194051 was associated with faster CD4 T-cell recovery (P=0.006). Unlike Caucasians, we did not demonstrate a significant association between IL-7Rα haplotype 2 and faster CD4 T-cell recovery in Africans. The IL-7Rα SNPs associated with CD4 T-cell recovery following cART differ in African and Caucasian cohorts.Genes and Immunity advance online publication, 22 September 2011; doi:10.1038/gene.2011.65. 2011 Article PeerReviewed Rajasuriar, R. and Booth, D.R. and Gouillou, M. and Spelman, T. and James, I. and Solomon, A. and Chua, K. and Stewart, G. and Deeks, S. and Bangsberg, D.R. and Muzoora, C. and Cameron, P.U. and Hunt, P. and Martin, J. and Lewin, S.R. (2011) The role of SNPs in the α-chain of the IL-7R gene in CD4+ T-cell recovery in HIV-infected African patients receiving suppressive cART. Genes Immun. http://www.ncbi.nlm.nih.gov/pubmed/21938017 |
| spellingShingle | R Medicine Rajasuriar, R. Booth, D.R. Gouillou, M. Spelman, T. James, I. Solomon, A. Chua, K. Stewart, G. Deeks, S. Bangsberg, D.R. Muzoora, C. Cameron, P.U. Hunt, P. Martin, J. Lewin, S.R. The role of SNPs in the α-chain of the IL-7R gene in CD4+ T-cell recovery in HIV-infected African patients receiving suppressive cART |
| title | The role of SNPs in the α-chain of the IL-7R gene in CD4+ T-cell recovery in HIV-infected African patients receiving suppressive cART |
| title_full | The role of SNPs in the α-chain of the IL-7R gene in CD4+ T-cell recovery in HIV-infected African patients receiving suppressive cART |
| title_fullStr | The role of SNPs in the α-chain of the IL-7R gene in CD4+ T-cell recovery in HIV-infected African patients receiving suppressive cART |
| title_full_unstemmed | The role of SNPs in the α-chain of the IL-7R gene in CD4+ T-cell recovery in HIV-infected African patients receiving suppressive cART |
| title_short | The role of SNPs in the α-chain of the IL-7R gene in CD4+ T-cell recovery in HIV-infected African patients receiving suppressive cART |
| title_sort | role of snps in the α chain of the il 7r gene in cd4 t cell recovery in hiv infected african patients receiving suppressive cart |
| topic | R Medicine |
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