Design, synthesis and biological evaluation of organotin(IV) complexes of flumequine and cetirizine
Six new organotin(IV) derivatives [Me3SnL1] (1), [Bu3SnL1] (2), [Ph3SnL1] (3), [Me3SnL2] (4), [Bu3SnL2] (5) and [Ph3SnL2] (6) (where HL1 = = 9-fluoro-6,7-dihydro-5-methyl-1-oxo-1H,5H-pyrido[3,2,1-ij]quinoline-2-car-boxylic acid (flumequine) and HL2 = 2-[2-[4-[(4-chlorophenyl)phenylmethyl]--1-piperaz...
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| Format: | Article |
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Serbian Chemical Society
2018
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| author | Iftikhar, Syed Hassan Gilani, Syeda Rubina Taj, M. Babar Raheel, Ahmad Ud-Din-Imtiaz, - Termizi, Syed Ahmad Al-Shakban, Mundher Ali, Hapipah Mohd |
| author_facet | Iftikhar, Syed Hassan Gilani, Syeda Rubina Taj, M. Babar Raheel, Ahmad Ud-Din-Imtiaz, - Termizi, Syed Ahmad Al-Shakban, Mundher Ali, Hapipah Mohd |
| author_sort | Iftikhar, Syed Hassan |
| collection | UM |
| description | Six new organotin(IV) derivatives [Me3SnL1] (1), [Bu3SnL1] (2), [Ph3SnL1] (3), [Me3SnL2] (4), [Bu3SnL2] (5) and [Ph3SnL2] (6) (where HL1 = = 9-fluoro-6,7-dihydro-5-methyl-1-oxo-1H,5H-pyrido[3,2,1-ij]quinoline-2-car-boxylic acid (flumequine) and HL2 = 2-[2-[4-[(4-chlorophenyl)phenylmethyl]--1-piperazinyl]ethoxy] acetic acid (cetirizine)) were synthesized and characterized by elemental analysis, FT-IR spectroscopy, multinuclear 1H-, 13C- and 119Sn-NMR, mass spectrometry and thermal analysis techniques. The obtained data reveal trigonal-bipyramidal geometry in case of complexes 1, 2, 4 and 5, and tetrahedral geometry for complexes 3 and 6 around the tin atom, whereas in complexes 3 and 6 the carboxylate ligand act as monodentate ligand through one of its oxygen atoms while it acts as bidentate ligand through two oxygen atoms for complexes 1, 2, 4 and 5. The antibacterial and antifungal efficacies of complexes 1–6 were assessed and the majority of the compounds showed good activities. The present research showed that the trimethyltin(IV) derivatives were particularly more effective than tributyltin(IV) and triphenyltin(IV) derivatives against all the bacterial and fungal strains. Antioxidant and DNA binding studies were also performed and promising results were obtained. |
| first_indexed | 2024-03-06T05:55:14Z |
| format | Article |
| id | um.eprints-21819 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:55:14Z |
| publishDate | 2018 |
| publisher | Serbian Chemical Society |
| record_format | dspace |
| spelling | um.eprints-218192019-08-06T03:15:22Z http://eprints.um.edu.my/21819/ Design, synthesis and biological evaluation of organotin(IV) complexes of flumequine and cetirizine Iftikhar, Syed Hassan Gilani, Syeda Rubina Taj, M. Babar Raheel, Ahmad Ud-Din-Imtiaz, - Termizi, Syed Ahmad Al-Shakban, Mundher Ali, Hapipah Mohd Q Science (General) QD Chemistry Six new organotin(IV) derivatives [Me3SnL1] (1), [Bu3SnL1] (2), [Ph3SnL1] (3), [Me3SnL2] (4), [Bu3SnL2] (5) and [Ph3SnL2] (6) (where HL1 = = 9-fluoro-6,7-dihydro-5-methyl-1-oxo-1H,5H-pyrido[3,2,1-ij]quinoline-2-car-boxylic acid (flumequine) and HL2 = 2-[2-[4-[(4-chlorophenyl)phenylmethyl]--1-piperazinyl]ethoxy] acetic acid (cetirizine)) were synthesized and characterized by elemental analysis, FT-IR spectroscopy, multinuclear 1H-, 13C- and 119Sn-NMR, mass spectrometry and thermal analysis techniques. The obtained data reveal trigonal-bipyramidal geometry in case of complexes 1, 2, 4 and 5, and tetrahedral geometry for complexes 3 and 6 around the tin atom, whereas in complexes 3 and 6 the carboxylate ligand act as monodentate ligand through one of its oxygen atoms while it acts as bidentate ligand through two oxygen atoms for complexes 1, 2, 4 and 5. The antibacterial and antifungal efficacies of complexes 1–6 were assessed and the majority of the compounds showed good activities. The present research showed that the trimethyltin(IV) derivatives were particularly more effective than tributyltin(IV) and triphenyltin(IV) derivatives against all the bacterial and fungal strains. Antioxidant and DNA binding studies were also performed and promising results were obtained. Serbian Chemical Society 2018 Article PeerReviewed Iftikhar, Syed Hassan and Gilani, Syeda Rubina and Taj, M. Babar and Raheel, Ahmad and Ud-Din-Imtiaz, - and Termizi, Syed Ahmad and Al-Shakban, Mundher and Ali, Hapipah Mohd (2018) Design, synthesis and biological evaluation of organotin(IV) complexes of flumequine and cetirizine. Journal of the Serbian Chemical Society, 83 (4). pp. 425-437. ISSN 0352-5139, DOI https://doi.org/10.2298/JSC161203070I <https://doi.org/10.2298/JSC161203070I>. https://doi.org/10.2298/JSC161203070I doi:10.2298/JSC161203070I |
| spellingShingle | Q Science (General) QD Chemistry Iftikhar, Syed Hassan Gilani, Syeda Rubina Taj, M. Babar Raheel, Ahmad Ud-Din-Imtiaz, - Termizi, Syed Ahmad Al-Shakban, Mundher Ali, Hapipah Mohd Design, synthesis and biological evaluation of organotin(IV) complexes of flumequine and cetirizine |
| title | Design, synthesis and biological evaluation of organotin(IV) complexes of flumequine and cetirizine |
| title_full | Design, synthesis and biological evaluation of organotin(IV) complexes of flumequine and cetirizine |
| title_fullStr | Design, synthesis and biological evaluation of organotin(IV) complexes of flumequine and cetirizine |
| title_full_unstemmed | Design, synthesis and biological evaluation of organotin(IV) complexes of flumequine and cetirizine |
| title_short | Design, synthesis and biological evaluation of organotin(IV) complexes of flumequine and cetirizine |
| title_sort | design synthesis and biological evaluation of organotin iv complexes of flumequine and cetirizine |
| topic | Q Science (General) QD Chemistry |
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