Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia
The risk of having microvascular complication is high among Type 2 Diabetes Mellitus (T2DM) patients. However, factors associated with the glycemic control and progression of diabetic retinopathy (DR) in T2DM patients is limited. This study aims to determine association between anti-diabetic agents,...
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| Format: | Article |
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Universidade de Sao Paulo
2018
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| _version_ | 1825721763759128576 |
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| author | Huri, Hasniza Zaman Chua, Chew Huey Mustafa, Norasyikin Mohamad, Nor Fadhilah Kamalden, Tengku Ain |
| author_facet | Huri, Hasniza Zaman Chua, Chew Huey Mustafa, Norasyikin Mohamad, Nor Fadhilah Kamalden, Tengku Ain |
| author_sort | Huri, Hasniza Zaman |
| collection | UM |
| description | The risk of having microvascular complication is high among Type 2 Diabetes Mellitus (T2DM) patients. However, factors associated with the glycemic control and progression of diabetic retinopathy (DR) in T2DM patients is limited. This study aims to determine association between anti-diabetic agents, glycemic control and progression of diabetic retinopathy in a Malaysian population. A retrospective study conducted in a tertiary teaching hospital in Malaysia, from January 2009 until March 2014. This study enrolled 104 patients aged 40-84 years, with a mean age 63.12 ± 9.18 years. patients had non-proliferative diabetic retinopathy (NPDR, 77%) and 35% had proliferative diabetic retinopathy (PDR). Diabetic macula edema (DME) was present in 20% of NPDR patients, compared with 7% in PDR. Alpha-glucosidase inhibitor (p=0.012), age (p=0.014) and number of antidiabetic agents used (p=0.015) were significantly associated with stages of diabetic retinopathy. Family history of T2DM (p=0.039) was associated with DME. Identifying factors influencing the progression of diabetic retinopathy may aid in optimizing the therapeutic effects of anti-diabetic agents in T2DM patients. |
| first_indexed | 2024-03-06T05:55:18Z |
| format | Article |
| id | um.eprints-21853 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:55:18Z |
| publishDate | 2018 |
| publisher | Universidade de Sao Paulo |
| record_format | dspace |
| spelling | um.eprints-218532019-08-07T04:18:22Z http://eprints.um.edu.my/21853/ Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia Huri, Hasniza Zaman Chua, Chew Huey Mustafa, Norasyikin Mohamad, Nor Fadhilah Kamalden, Tengku Ain R Medicine The risk of having microvascular complication is high among Type 2 Diabetes Mellitus (T2DM) patients. However, factors associated with the glycemic control and progression of diabetic retinopathy (DR) in T2DM patients is limited. This study aims to determine association between anti-diabetic agents, glycemic control and progression of diabetic retinopathy in a Malaysian population. A retrospective study conducted in a tertiary teaching hospital in Malaysia, from January 2009 until March 2014. This study enrolled 104 patients aged 40-84 years, with a mean age 63.12 ± 9.18 years. patients had non-proliferative diabetic retinopathy (NPDR, 77%) and 35% had proliferative diabetic retinopathy (PDR). Diabetic macula edema (DME) was present in 20% of NPDR patients, compared with 7% in PDR. Alpha-glucosidase inhibitor (p=0.012), age (p=0.014) and number of antidiabetic agents used (p=0.015) were significantly associated with stages of diabetic retinopathy. Family history of T2DM (p=0.039) was associated with DME. Identifying factors influencing the progression of diabetic retinopathy may aid in optimizing the therapeutic effects of anti-diabetic agents in T2DM patients. Universidade de Sao Paulo 2018 Article PeerReviewed Huri, Hasniza Zaman and Chua, Chew Huey and Mustafa, Norasyikin and Mohamad, Nor Fadhilah and Kamalden, Tengku Ain (2018) Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia. Brazilian Journal of Pharmaceutical Sciences, 54 (2). e17484. ISSN 2175-9790, DOI https://doi.org/10.1590/s2175-97902018000217484 <https://doi.org/10.1590/s2175-97902018000217484>. https://doi.org/10.1590/s2175-97902018000217484 doi:10.1590/s2175-97902018000217484 |
| spellingShingle | R Medicine Huri, Hasniza Zaman Chua, Chew Huey Mustafa, Norasyikin Mohamad, Nor Fadhilah Kamalden, Tengku Ain Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia |
| title | Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia |
| title_full | Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia |
| title_fullStr | Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia |
| title_full_unstemmed | Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia |
| title_short | Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia |
| title_sort | association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in malaysia |
| topic | R Medicine |
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