One-Pot Multicomponent Synthesis of Pyrazolo[3,4-d]pyrimidine-6-one Derivatives
An environmentally benign, simple, and efficient procedure has been developed for the one-pot multicomponent synthesis of pyrazolo[3,4-d]pyrimidine-6-one derivatives by the reaction of the variety of aryl-aldehydes, 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and urea in the presence of catalyti...
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| Format: | Article |
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Taylor & Francis
2018
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| author | Hamid, Sharifah Bee Abd Titinchi, Salam J.J. Abbo, Hanna Khaligh, Nader Ghaffari |
| author_facet | Hamid, Sharifah Bee Abd Titinchi, Salam J.J. Abbo, Hanna Khaligh, Nader Ghaffari |
| author_sort | Hamid, Sharifah Bee Abd |
| collection | UM |
| description | An environmentally benign, simple, and efficient procedure has been developed for the one-pot multicomponent synthesis of pyrazolo[3,4-d]pyrimidine-6-one derivatives by the reaction of the variety of aryl-aldehydes, 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and urea in the presence of catalytic amount of poly(N-vinylpyridinium) hydrogen sulfate in glycerol. The present method affords non-toxic and non-corrosive medium, short reaction times, high yield of the products, mild reaction conditions as well as simple experimental and isolation procedures. The catalyst can be recycled by simple filtration and reused without any significant reduction in its activity. |
| first_indexed | 2024-03-06T05:55:39Z |
| format | Article |
| id | um.eprints-21965 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:55:39Z |
| publishDate | 2018 |
| publisher | Taylor & Francis |
| record_format | dspace |
| spelling | um.eprints-219652019-08-20T03:30:17Z http://eprints.um.edu.my/21965/ One-Pot Multicomponent Synthesis of Pyrazolo[3,4-d]pyrimidine-6-one Derivatives Hamid, Sharifah Bee Abd Titinchi, Salam J.J. Abbo, Hanna Khaligh, Nader Ghaffari Q Science (General) QD Chemistry An environmentally benign, simple, and efficient procedure has been developed for the one-pot multicomponent synthesis of pyrazolo[3,4-d]pyrimidine-6-one derivatives by the reaction of the variety of aryl-aldehydes, 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and urea in the presence of catalytic amount of poly(N-vinylpyridinium) hydrogen sulfate in glycerol. The present method affords non-toxic and non-corrosive medium, short reaction times, high yield of the products, mild reaction conditions as well as simple experimental and isolation procedures. The catalyst can be recycled by simple filtration and reused without any significant reduction in its activity. Taylor & Francis 2018 Article PeerReviewed Hamid, Sharifah Bee Abd and Titinchi, Salam J.J. and Abbo, Hanna and Khaligh, Nader Ghaffari (2018) One-Pot Multicomponent Synthesis of Pyrazolo[3,4-d]pyrimidine-6-one Derivatives. Polycyclic Aromatic Compounds, 38 (2). pp. 189-198. ISSN 1040-6638, DOI https://doi.org/10.1080/10406638.2016.1194298 <https://doi.org/10.1080/10406638.2016.1194298>. https://doi.org/10.1080/10406638.2016.1194298 doi:10.1080/10406638.2016.1194298 |
| spellingShingle | Q Science (General) QD Chemistry Hamid, Sharifah Bee Abd Titinchi, Salam J.J. Abbo, Hanna Khaligh, Nader Ghaffari One-Pot Multicomponent Synthesis of Pyrazolo[3,4-d]pyrimidine-6-one Derivatives |
| title | One-Pot Multicomponent Synthesis of Pyrazolo[3,4-d]pyrimidine-6-one Derivatives |
| title_full | One-Pot Multicomponent Synthesis of Pyrazolo[3,4-d]pyrimidine-6-one Derivatives |
| title_fullStr | One-Pot Multicomponent Synthesis of Pyrazolo[3,4-d]pyrimidine-6-one Derivatives |
| title_full_unstemmed | One-Pot Multicomponent Synthesis of Pyrazolo[3,4-d]pyrimidine-6-one Derivatives |
| title_short | One-Pot Multicomponent Synthesis of Pyrazolo[3,4-d]pyrimidine-6-one Derivatives |
| title_sort | one pot multicomponent synthesis of pyrazolo 3 4 d pyrimidine 6 one derivatives |
| topic | Q Science (General) QD Chemistry |
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