Effect of Aging on NK Cell Population and Their Proliferation at Ex Vivo Culture Condition

Age-associated changes in natural killer (NK) cell population, phenotype, and functions are directly attributed to the risk of several diseases and infections. It is predicted to be the major cause of the increase in mortality. Based on the surface density of CD56, NK cells are subdivided into two t...

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Main Authors: Gounder, Sellamuthu Subbanna, Abdullah, Basri Johan Jeet, Radzuanb, Nur Ezzati Izyan Mohd, Zain, Farah Dalila Mohd, Sait, Nurhidayah Mohamad, Chua, Corine, Subramani, Baskar
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Published: Hindawi 2018
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author Gounder, Sellamuthu Subbanna
Abdullah, Basri Johan Jeet
Radzuanb, Nur Ezzati Izyan Mohd
Zain, Farah Dalila Mohd
Sait, Nurhidayah Mohamad
Chua, Corine
Subramani, Baskar
author_facet Gounder, Sellamuthu Subbanna
Abdullah, Basri Johan Jeet
Radzuanb, Nur Ezzati Izyan Mohd
Zain, Farah Dalila Mohd
Sait, Nurhidayah Mohamad
Chua, Corine
Subramani, Baskar
author_sort Gounder, Sellamuthu Subbanna
collection UM
description Age-associated changes in natural killer (NK) cell population, phenotype, and functions are directly attributed to the risk of several diseases and infections. It is predicted to be the major cause of the increase in mortality. Based on the surface density of CD56, NK cells are subdivided into two types, such as CD56 bright and CD56 dim cells, which represent cytokine production and cytotoxicity. In our study, we have examined the age-associated changes in the NK cell population and their subsets at different age groups of males and females (at a range from 41 to 80 years). We found that the total lymphocyte count significantly dropped upon aging in both genders. Although, the level of total immune cells also dropped on aging, and surprisingly the total NK cell population was remarkably increased with the majority of NK cells being CD56 dim . Subsequently, we evaluated the proliferation potential of NK cells and our results showed that the NK cell proliferation ability declines with age. Overall, our findings prove that there is an increase in the circulating NK cell population upon aging. However, the proliferation rate upon aging declines when compared to the young age group (<41 yrs).
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spelling um.eprints-220012019-08-20T09:13:39Z http://eprints.um.edu.my/22001/ Effect of Aging on NK Cell Population and Their Proliferation at Ex Vivo Culture Condition Gounder, Sellamuthu Subbanna Abdullah, Basri Johan Jeet Radzuanb, Nur Ezzati Izyan Mohd Zain, Farah Dalila Mohd Sait, Nurhidayah Mohamad Chua, Corine Subramani, Baskar R Medicine Age-associated changes in natural killer (NK) cell population, phenotype, and functions are directly attributed to the risk of several diseases and infections. It is predicted to be the major cause of the increase in mortality. Based on the surface density of CD56, NK cells are subdivided into two types, such as CD56 bright and CD56 dim cells, which represent cytokine production and cytotoxicity. In our study, we have examined the age-associated changes in the NK cell population and their subsets at different age groups of males and females (at a range from 41 to 80 years). We found that the total lymphocyte count significantly dropped upon aging in both genders. Although, the level of total immune cells also dropped on aging, and surprisingly the total NK cell population was remarkably increased with the majority of NK cells being CD56 dim . Subsequently, we evaluated the proliferation potential of NK cells and our results showed that the NK cell proliferation ability declines with age. Overall, our findings prove that there is an increase in the circulating NK cell population upon aging. However, the proliferation rate upon aging declines when compared to the young age group (<41 yrs). Hindawi 2018 Article PeerReviewed Gounder, Sellamuthu Subbanna and Abdullah, Basri Johan Jeet and Radzuanb, Nur Ezzati Izyan Mohd and Zain, Farah Dalila Mohd and Sait, Nurhidayah Mohamad and Chua, Corine and Subramani, Baskar (2018) Effect of Aging on NK Cell Population and Their Proliferation at Ex Vivo Culture Condition. Analytical Cellular Pathology, 2018. pp. 1-6. ISSN 2210-7177, DOI https://doi.org/10.1155/2018/7871814 <https://doi.org/10.1155/2018/7871814>. https://doi.org/10.1155/2018/7871814 doi:10.1155/2018/7871814
spellingShingle R Medicine
Gounder, Sellamuthu Subbanna
Abdullah, Basri Johan Jeet
Radzuanb, Nur Ezzati Izyan Mohd
Zain, Farah Dalila Mohd
Sait, Nurhidayah Mohamad
Chua, Corine
Subramani, Baskar
Effect of Aging on NK Cell Population and Their Proliferation at Ex Vivo Culture Condition
title Effect of Aging on NK Cell Population and Their Proliferation at Ex Vivo Culture Condition
title_full Effect of Aging on NK Cell Population and Their Proliferation at Ex Vivo Culture Condition
title_fullStr Effect of Aging on NK Cell Population and Their Proliferation at Ex Vivo Culture Condition
title_full_unstemmed Effect of Aging on NK Cell Population and Their Proliferation at Ex Vivo Culture Condition
title_short Effect of Aging on NK Cell Population and Their Proliferation at Ex Vivo Culture Condition
title_sort effect of aging on nk cell population and their proliferation at ex vivo culture condition
topic R Medicine
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