Alkaloids from Cryptocarya densiflora Blume (Lauraceae) and their cholinesterase inhibitory activity
(−)-Desmethylsecoantofine N-oxide (1), a new seco-phenanthroindolizidine alkaloid along with prodensiflorins A and B (2-3), two new proaporphine alkaloids, were isolated from the leaves of Cryptocarya densiflora Blume. Their structures were established on the basis of 1D and 2D NMR techniques and LC...
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| Format: | Article |
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Elsevier
2017
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| _version_ | 1825721947971911680 |
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| author | Wan Othman, Wan Nurul Nazneem Sivasothy, Yasodha Liew, Sook Yee Mohamad, Jamaludin Nafiah, Mohd Azlan Ahmad, Kartini Litaudon, Marc Awang, Khalijah |
| author_facet | Wan Othman, Wan Nurul Nazneem Sivasothy, Yasodha Liew, Sook Yee Mohamad, Jamaludin Nafiah, Mohd Azlan Ahmad, Kartini Litaudon, Marc Awang, Khalijah |
| author_sort | Wan Othman, Wan Nurul Nazneem |
| collection | UM |
| description | (−)-Desmethylsecoantofine N-oxide (1), a new seco-phenanthroindolizidine alkaloid along with prodensiflorins A and B (2-3), two new proaporphine alkaloids, were isolated from the leaves of Cryptocarya densiflora Blume. Their structures were established on the basis of 1D and 2D NMR techniques and LCMS-IT-TOF analysis. (+)-N-methyllaurotetanine (4), (+)-laurotetanine (5), (+)-nornantenine (6), crychine (7), (−)-isocaryachine (8), (+)-reticuline (9), (−)-desmethylsecoantofine (10), (+)-oridine (11), dicentrinone (12) and (−)-antofine (13) were also isolated with compounds 4, 7–9 and 12–13 being characterized for the first time in this plant. Compounds 1-3 were moderate to weak AChE and BChE inhibitors while compound 10 was a DPPH free radical scavenger. |
| first_indexed | 2024-03-06T05:58:08Z |
| format | Article |
| id | um.eprints-22831 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:58:08Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | um.eprints-228312019-10-24T04:00:29Z http://eprints.um.edu.my/22831/ Alkaloids from Cryptocarya densiflora Blume (Lauraceae) and their cholinesterase inhibitory activity Wan Othman, Wan Nurul Nazneem Sivasothy, Yasodha Liew, Sook Yee Mohamad, Jamaludin Nafiah, Mohd Azlan Ahmad, Kartini Litaudon, Marc Awang, Khalijah Q Science (General) QD Chemistry QH Natural history (−)-Desmethylsecoantofine N-oxide (1), a new seco-phenanthroindolizidine alkaloid along with prodensiflorins A and B (2-3), two new proaporphine alkaloids, were isolated from the leaves of Cryptocarya densiflora Blume. Their structures were established on the basis of 1D and 2D NMR techniques and LCMS-IT-TOF analysis. (+)-N-methyllaurotetanine (4), (+)-laurotetanine (5), (+)-nornantenine (6), crychine (7), (−)-isocaryachine (8), (+)-reticuline (9), (−)-desmethylsecoantofine (10), (+)-oridine (11), dicentrinone (12) and (−)-antofine (13) were also isolated with compounds 4, 7–9 and 12–13 being characterized for the first time in this plant. Compounds 1-3 were moderate to weak AChE and BChE inhibitors while compound 10 was a DPPH free radical scavenger. Elsevier 2017 Article PeerReviewed Wan Othman, Wan Nurul Nazneem and Sivasothy, Yasodha and Liew, Sook Yee and Mohamad, Jamaludin and Nafiah, Mohd Azlan and Ahmad, Kartini and Litaudon, Marc and Awang, Khalijah (2017) Alkaloids from Cryptocarya densiflora Blume (Lauraceae) and their cholinesterase inhibitory activity. Phytochemistry Letters, 21. pp. 230-236. ISSN 1874-3900, DOI https://doi.org/10.1016/j.phytol.2017.07.002 <https://doi.org/10.1016/j.phytol.2017.07.002>. https://doi.org/10.1016/j.phytol.2017.07.002 doi:10.1016/j.phytol.2017.07.002 |
| spellingShingle | Q Science (General) QD Chemistry QH Natural history Wan Othman, Wan Nurul Nazneem Sivasothy, Yasodha Liew, Sook Yee Mohamad, Jamaludin Nafiah, Mohd Azlan Ahmad, Kartini Litaudon, Marc Awang, Khalijah Alkaloids from Cryptocarya densiflora Blume (Lauraceae) and their cholinesterase inhibitory activity |
| title | Alkaloids from Cryptocarya densiflora Blume (Lauraceae) and their cholinesterase inhibitory activity |
| title_full | Alkaloids from Cryptocarya densiflora Blume (Lauraceae) and their cholinesterase inhibitory activity |
| title_fullStr | Alkaloids from Cryptocarya densiflora Blume (Lauraceae) and their cholinesterase inhibitory activity |
| title_full_unstemmed | Alkaloids from Cryptocarya densiflora Blume (Lauraceae) and their cholinesterase inhibitory activity |
| title_short | Alkaloids from Cryptocarya densiflora Blume (Lauraceae) and their cholinesterase inhibitory activity |
| title_sort | alkaloids from cryptocarya densiflora blume lauraceae and their cholinesterase inhibitory activity |
| topic | Q Science (General) QD Chemistry QH Natural history |
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